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Weakly immunogenic CRISPR therapies

Orthologues of CRISPR-associated proteins and of viral vectors evade immune recognition in mice, enabling repeated gene therapy.

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Fig. 1: Potential methods for reducing immune responses to Cas9.

References

  1. Marshall, E. Science 286, 2244–2245 (1999).

    CAS  Article  Google Scholar 

  2. Mingozzi, F. & High, K. A. Blood 122, 23–36 (2013).

    CAS  Article  Google Scholar 

  3. Vandamme, C., Adjali, O. & Mingozzi, F. Hum. Gene Ther. 28, 1061–1074 (2017).

    CAS  Article  Google Scholar 

  4. Wang, D. et al. Hum. Gene Ther. 26, 432–442 (2015).

    CAS  Article  Google Scholar 

  5. Chew, W. L. et al. Nat. Methods 13, 868–874 (2016).

    CAS  Article  Google Scholar 

  6. Simhadri, V. L. et al. Mol. Ther. Methods Clin. Dev. 10, 105–112 (2018).

    CAS  Article  Google Scholar 

  7. Wagner, D. L. et al. Nat. Med. 25, 242–248 (2018).

    Article  Google Scholar 

  8. Ferdosi, S. R. et al. Nat. Commun. 10, 1842 (2019).

    Article  Google Scholar 

  9. Charlesworth, C. T. et al. Nat. Med. 25, 249–254 (2019).

    CAS  Article  Google Scholar 

  10. Moreno, A. M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0431-2 (2019).

Download references

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Correspondence to Karen S. Anderson.

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K.S.A. is noted as an inventor on a patent application regarding Cas9 immunity.

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Wilson, E.A., Anderson, K.S. Weakly immunogenic CRISPR therapies. Nat Biomed Eng 3, 761–762 (2019). https://doi.org/10.1038/s41551-019-0463-7

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  • DOI: https://doi.org/10.1038/s41551-019-0463-7

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