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Weakly immunogenic CRISPR therapies

Orthologues of CRISPR-associated proteins and of viral vectors evade immune recognition in mice, enabling repeated gene therapy.

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Fig. 1: Potential methods for reducing immune responses to Cas9.


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Correspondence to Karen S. Anderson.

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K.S.A. is noted as an inventor on a patent application regarding Cas9 immunity.

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Wilson, E.A., Anderson, K.S. Weakly immunogenic CRISPR therapies. Nat Biomed Eng 3, 761–762 (2019).

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