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CANCER IMMUNOTHERAPY

Rewiring regulatory T cells for tumour killing

Nature Biomedical Engineering volume 3, pages 766–767 (2019)Cite this article

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In mouse models of cancer, the inhibition of a set of regulatory proteins improves checkpoint-blockade therapy by causing regulatory T cells to produce the cytokine interferon-γ.

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Fig. 1: Effect of TREG cells on immune cells.
Fig. 2: Effect of the CBM signalosome on the phenotype of TREG cells.

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  1. Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Tomasz Maj & Weiping Zou

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  1. Tomasz Maj
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  2. Weiping Zou
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Correspondence to Weiping Zou.

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Maj, T., Zou, W. Rewiring regulatory T cells for tumour killing. Nat Biomed Eng 3, 766–767 (2019). https://doi.org/10.1038/s41551-019-0443-y

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