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Unamplified gene sensing via Cas9 on graphene

An electrical biosensor that relies on the binding of target nucleic acid sequences to Cas9 immobilized on a graphene field-effect transistor enables the rapid detection of mutations in purified samples without the need for nucleic acid amplification.

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Fig. 1: CRISPR-powered biosensing.


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Correspondence to Can Dincer.

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Bruch, R., Urban, G.A. & Dincer, C. Unamplified gene sensing via Cas9 on graphene. Nat Biomed Eng 3, 419–420 (2019).

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