Neuroethical considerations of high-density electrode arrays

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The development of implantable electrode arrays that broadly and seamlessly integrate with brain tissue will require innovation that responsibly considers clinically relevant neuroethical concerns.

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Fig. 1: Summary of issues associated with traditional arrays, and considerations for high-density, next-generation arrays.

References

  1. 1.

    Bergey, G. K. et al. Neurology 84, 810–817 (2015).

  2. 2.

    Salatino, J. W., Ludwig, K. A., Kozai, T. D. & Purcell, E. K. Nat. Biomed. Eng. 1, 862–877 (2017).

  3. 3.

    Biran, R., Martin, D. C. & Tresco, P. A. Exp. Neurol. 195, 115–126 (2005).

  4. 4.

    Eles, J. R., Vazquez, A. L., Kozai, T. D. & Cui, X. T. Biomaterials 174, 79–94 (2018).

  5. 5.

    Salatino, J. W., Winter, B. M., Drazin, M. H. & Purcell, E. K. J. Neurophysiol. 118, 194–202 (2017).

  6. 6.

    Salatino, J. W., Kale, A. P. & Purcell, E. K. bioRxiv https://doi.org/10.1101/518811 (2019).

  7. 7.

    Thompson, C. H., Zoratti, M. J., Langhals, N. B. & Purcell, E. K. Tissue Eng. Pt B Rev. 22, 125–135 (2015).

  8. 8.

    Winter, B., Daniels, S., Salatino, J. & Purcell, E. Micromachines 9, 476 (2018).

  9. 9.

    Kozai, T. D. et al. Nat. Mater. 11, 1065–1073 (2012).

  10. 10.

    Jun, J. J. et al. Nature 551, 232–236 (2017).

  11. 11.

    Chen, R., Canales, A. & Anikeeva, P. Nat. Rev. Mater. 2, 16093 (2017).

  12. 12.

    Rodger, D. C. et al. Sens. Actuators B 132, 449–460 (2008).

  13. 13.

    Liu, J. et al. Nat. Nanotech. 10, 629–636 (2015).

  14. 14.

    Kim, D. H. et al. Science 320, 507–511 (2008).

  15. 15.

    Vera, J. & Martínez-Sánchez, F. Span. J. Psychol. 19, E1 (2016).

  16. 16.

    Lipsman, N. & Glannon, W. Bioethics 27, 465–470 (2012).

  17. 17.

    de Haan, S., Rietveld, E., Stokhof, M. & Denys, D. PLoS ONE 12, e0175748 (2017).

  18. 18.

    Goering, S., Klein, E., Dougherty, D. D. & Widge, A. S. AJOB Neurosci. 8, 59–70 (2017).

  19. 19.

    Gilbert, F. AJOB Neurosci. 6, 4–11 (2015).

  20. 20.

    Kraemer, F. Neuroethics 6, 483–497 (2011).

  21. 21.

    Yuste, R. et al. Nature 551, 159–163 (2017).

  22. 22.

    Clausen, J. et al. Science 356, 1338–1339 (2017).

  23. 23.

    Chhatbar, P. & Saha, S. J. Long Term Eff. Med. Implants 19, 123–127 (2009).

  24. 24.

    Greely, H. T. et al. J. Neurosci. 38, 10586–10588 (2018).

  25. 25.

    Van Gompel, J. J. J. Neurosurg. 25, E23 (2008).

  26. 26.

    Ramos, K. M. et al. Neuron 101, 394–398 (2019).

  27. 27.

    Chiong, W., Leonard, M. K. & Chang, E. F. Neurosurg. 6, 35 (2017).

  28. 28.

    Pycroft, L. et al. World Neurosurg. 92, 454–462 (2016).

  29. 29.

    Lacoste, A., Berenshteyn, F. & Brivanlou, A. H. Cell Stem Cell 5, 332–342 (2009).

  30. 30.

    Seo, D. et al. Neuron 91, 529–539 (2016).

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Acknowledgements

The authors thank K. Ludwig for his helpful feedback during the preparation of early drafts of this manuscript.

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Correspondence to Laura Cabrera.

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