Nanoparticle sensors of the activity of the protease granzyme B detect early T-cell-mediated rejection of transplanted skin grafts in mice via the release of a proteolytically cleaved fluorescence reporter that filters into urine.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Merrill, J. P., Murray, J. E., Harrison, J. H. & Guild, W. R. J. Am. Med. Assoc. 160, 277–282 (1956).
Roberts, D. M., Jiang, S. H. & Chadban, S. J. Transplantation 94, 775–783 (2012).
Hara, S. Nephrology 23, 45–51 (2018).
Nissaisorakarn, V., Lee, J. R., Lubetzky, M. & Suthanthiran, M. Hum. Immunol. 79, 343–355 (2018).
Kummer, J. A. et al. Kidney Int. 47, 70–77 (1995).
Mac, Q. D. et al. Nat. Biomed.Eng. https://doi.org/10.1038/s41551-019-0358-7 (2019).
Kataoka, T. & Nagai, K. Immunol. Lett. 72, 49–52 (2000).
Venner, J. M. et al. Am. J. Transplant. 14, 2565–2576 (2014).
Litjens, N. H. R. et al. Front. Immunol. 8, 1137 (2017).
Leboeuf, C. et al. Am. J. Transplant. 17, 2591–2600 (2017).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chong, A.S. Urinary nanosensors of early transplant rejection. Nat Biomed Eng 3, 251–252 (2019). https://doi.org/10.1038/s41551-019-0389-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-019-0389-0