An inexpensive assay that uses thermophoresis to concentrate cancer extracellular vesicles bound to aptamers specific for target proteins on the vesicles’ surface, can classify cancer patients according to cancer type and stage.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer
Nature Communications Open Access 05 May 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 /Â 30Â days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cohen, J. D. et al. Science 359, 926–930 (2018).
Diaz, L. A. Jr. & Bardelli, A. J. Clin. Oncol. 32, 579–586 (2014).
Im, H. et al. Nat. Biotechnol. 32, 490–495 (2014).
Issadore, D. et al. Sci. Transl. Med. 4, 141ra92 (2012).
Karabacak, N. M. et al. Nat. Protoc. 9, 694–710 (2014).
Poudineh, M. et al. Nat. Biomed. Eng. 2, 72–84 (2018).
Balaj, L. et al. Nat. Commun. 2, 180 (2011).
Graner, M. W. et al. FASEB J. 23, 1541–1557 (2009).
Skog, J. et al. Nat. Cell Biol. 10, 1470–1476 (2008).
Valadi, H. et al. Nat. Cell Biol. 9, 654–659 (2007).
Théry, C. et al. Curr. Protoc. Cell. Biol. 30, 3.22.1–3.22.29 (2006).
Witwer, K. W. et al. J Extracell. Vesicles 2, 20360 (2013).
Shao, H. et al. Chem. Rev. 118, 1917–1950 (2018).
Liu, C. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0343-6 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
H.L. and C.M.C. are inventors on pending patents on nanoplasmonic and electrochemical-based profiling of exosomes.
Rights and permissions
About this article
Cite this article
Lee, H., Castro, C.M. Thermophoretically enriched detection. Nat Biomed Eng 3, 163–164 (2019). https://doi.org/10.1038/s41551-019-0364-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-019-0364-9
This article is cited by
-
Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment
Breast Cancer Research and Treatment (2022)
-
Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer
Nature Communications (2021)