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Cocaine-metabolizing skin grafts

Nature Biomedical Engineering volume 3, pages 81–82 (2019)Cite this article

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Graftable skin expressing an enzyme that metabolizes cocaine may offer a new strategy to treat cocaine addiction.

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Fig. 1: Skin grafts secreting a cocaine-metabolizing enzyme.

References

  1. Li, Y. K. Q., Yue, J., Gou, X., Xu, M. & Wu, X. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0293-z (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Hoffman, R. S. et al. Ann. Emerg. Med. 21, 247–253 (1992).

    Article  CAS  Google Scholar 

  3. Lynch, T. J. et al. Toxicol. Appl. Pharmacol. 145, 363–371 (1997).

    Article  CAS  Google Scholar 

  4. Carmona, G. N. et al. Exp. Clin. Psychopharmacol. 6, 274–279 (1998).

    Article  CAS  Google Scholar 

  5. Koetzner, L. & Woods, J. H. Drug Metab. Dispos. 30, 716–723 (2002).

    Article  CAS  Google Scholar 

  6. Schindler, C. W. & Goldberg, S. R. Future Med. Chem. 4, 163–175 (2012).

    Article  CAS  Google Scholar 

  7. Yue, J., Gou, X., Li, Y., Wicksteed, B. & Wu, X. Cell Stem Cell 21, 256–263 (2017).

    Article  CAS  Google Scholar 

  8. Wakabayashi, K. T., Weiss, M. J., Pickup, K. N. & Robinson, T. E. J. Neurosci. 30, 11346–11355 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Xin-an Liu & Paul J. Kenny

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  1. Xin-an Liu
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  2. Paul J. Kenny
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Correspondence to Paul J. Kenny.

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Liu, Xa., Kenny, P.J. Cocaine-metabolizing skin grafts. Nat Biomed Eng 3, 81–82 (2019). https://doi.org/10.1038/s41551-019-0355-x

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