The precision of the delivery of therapeutics to the desired injection site by syringes and hollow needles typically depends on the operator. Here, we introduce a highly sensitive, completely mechanical and cost-effective injector for targeting tissue reliably and precisely. As the operator pushes the syringe plunger, the injector senses the loss-of-resistance on encountering a softer tissue or a cavity, stops advancing the needle and delivers the payload. We demonstrate that the injector can reliably deliver liquids to the suprachoroidal space—a challenging injection site that provides access to the back of the eye—for a wide range of eye sizes, scleral thicknesses and intraocular pressures, and target sites relevant for epidural injections, subcutaneous injections and intraperitoneal access. The design of this simple and effective injector can be adapted for a broad variety of clinical applications.
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The authors declare that all data supporting the findings of this study are available within the paper and its supplementary information.
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Funding for this research was provided by grant no. R01HL095722 to J.M.K. Animal experiments were funded through the Boston-KPro research fund to M.G.A. and A.C. We thank Y. Jung and C. P. Lin for use of the intravital microscope, H. G. Lin and Harvard’s Center for Nanoscale Systems for use of the microCT system, and K. Cormier and the Hope Babette Tang Histology Facility at the Koch Institute at MIT for performing histology sections. We also thank the Schepens Eye Research Institute’s Animal Facility, especially J. Hoadley, M. Ortega and C. Beiler for their help. We appreciate the feedback on performing SCS injections with an I2T2 from D. Vavvas, V. Satitpitakul and K. Suri, from the Massachusetts Eye and Ear Infirmary.
The authors declare no competing interests.
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Supplementary methods, figures, tables and video captions.
Ventricular access through the heart wall by using i2T2 (ex vivo model).
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Chitnis, G.D., Verma, M.K.S., Lamazouade, J. et al. A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue. Nat Biomed Eng 3, 621–631 (2019). https://doi.org/10.1038/s41551-019-0350-2
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