News & Views | Published:

IMPLANTED BIOMATERIALS

Engineered niches model the onset of metastasis

Nature Biomedical Engineeringvolume 2pages885887 (2018) | Download Citation

A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Steeg, P. S. Nat. Rev. Cancer 16, 201–218 (2016).

  2. 2.

    Peinado, H. et al. Nat. Rev. Cancer 17, 302–317 (2017).

  3. 3.

    Sosa, M. S., Bragado, P. & Aguirre-Ghiso, J. A. Nat. Rev. Cancer 14, 611–622 (2014).

  4. 4.

    Ghajar, C. M. et al. Nat. Cell Biol. 15, 807–817 (2013).

  5. 5.

    Aguado, B. A., Bushnell, G. G., Rao, S. S., Jeruss, J. S. & Shea, L. D. Nat. Biomed. Eng. 1, 0077 (2017).

  6. 6.

    Mohme, M., Riethdorf, S. & Pantel, K. Nat. Rev. Clin. Oncol. 14, 155–167 (2017).

  7. 7.

    Gu, L. & Mooney, D. J. Nat. Rev. Cancer 16, 56–66 (2016).

  8. 8.

    Wang, F. et al. Proc. Natl Acad. Sci. USA 95, 14821–14826 (1998).

  9. 9.

    Carpenter, R. A., Kwak, J.-G., Peyton, S. R. & Lee, J. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0307-x (2018).

  10. 10.

    Chung, K. et al. Nature 497, 332–337 (2013).

  11. 11.

    Rao, S. S. et al. Cancer Res. 76, 5209–5218 (2016).

  12. 12.

    Azarin, S. M. et al. Nat. Commun. 6, 8094 (2015).

  13. 13.

    Vermesh, O. et al. Nat. Biomed. Eng. 2, 696–705 (2018).

  14. 14.

    Kang, Y. & Pantel, K. Cancer Cell 23, 573–581 (2013).

  15. 15.

    Oudin, M. J. & Weaver, V. M. Cold Spring Harb. Lab. Sym. 81, 189–205 (2016).

Download references

Author information

Affiliations

  1. Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

    • Irina Matei
    • , Sham Rampersaud
    •  & David Lyden

Authors

  1. Search for Irina Matei in:

  2. Search for Sham Rampersaud in:

  3. Search for David Lyden in:

Corresponding authors

Correspondence to Irina Matei or David Lyden.

About this article

Publication history

Published

Issue Date

DOI

https://doi.org/10.1038/s41551-018-0326-7

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing