Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CANCER NANOMEDICINE

Efficient siRNA delivery with non-cationic carriers

Self-assembled weakly negative nanoparticles bearing an octet of short interfering RNAs, targeting ligands and endosomolytic peptides lead to efficient gene silencing in a mouse model of prostate cancer.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Non-cationic nanostructures for in vivo gene silencing via RNAi.

References

  1. 1.

    Pecot, C. V., Calin, G. A., Coleman, R. L., Lopez-Berestein, G. & Sood, A. K. Nat. Rev. Cancer 11, 59–67 (2011).

    Article  PubMed  CAS  Google Scholar 

  2. 2.

    Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Nat. Rev. Cancer 17, 20–37 (2017).

    Article  PubMed  CAS  Google Scholar 

  3. 3.

    Davis, M. E. et al. Nature 464, 1067–1070 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. 4.

    Wilhelm, S. et al. Nat. Rev. Mater. 1, 16014 (2016).

    Article  CAS  Google Scholar 

  5. 5.

    Zuckerman, J. E. et al. Proc. Natl Acad. Sci. USA 111, 11449–11454 (2014).

    Article  PubMed  CAS  Google Scholar 

  6. 6.

    Zuckerman, J. E., Choi, C. H. J., Han, H. & Davis, M. E. Proc. Natl Acad. Sci. USA 109, 3137–3142 (2012).

    Article  PubMed  Google Scholar 

  7. 7.

    Wittrup, A. et al. Nat. Biotechnol. 33, 870–876 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. 8.

    Gilleron, J. et al. Nat. Biotechnol. 31, 638–646 (2013).

    Article  PubMed  CAS  Google Scholar 

  9. 9.

    Tai, W., Li, J., Corey, E. & Gao, X. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0214-1 (2018).

  10. 10.

    Lee, H. et al. Nat. Nanotech. 7, 389–393 (2012).

    Article  CAS  Google Scholar 

  11. 11.

    Jensen, S. A. et al. Sci. Transl. Med. 5, 209ra152 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. 12.

    Pi, F. et al. Nat. Nanotech. 13, 82–89 (2018).

    Article  CAS  Google Scholar 

  13. 13.

    Ding, F. et al. Angew. Chem. Int. Ed. 57, 3064–3068 (2018).

    Article  CAS  Google Scholar 

  14. 14.

    Praetorius, F. et al. Nature 552, 84–87 (2017).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Chung Hang Jonathan Choi.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Choi, C.K.K., Zhang, L. & Choi, C.H.J. Efficient siRNA delivery with non-cationic carriers. Nat Biomed Eng 2, 275–276 (2018). https://doi.org/10.1038/s41551-018-0240-z

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing