News & Views | Published:

DIAGNOSTIC DEVICES

Detecting sepsis by observing neutrophil motility

Nature Biomedical Engineeringvolume 2pages197198 (2018) | Download Citation

A microfluidic device for assaying neutrophil motility in blood samples from sepsis patients and a machine-learning algorithm trained with the motility data enable a faster and accurate sepsis diagnosis.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Gaieski, D. F., Edwards, J. M., Kallan, M. J. & Carr, B. G. Crit. Care Med. 41, 1167–1174 (2013).

  2. 2.

    Adhikari, N. K. J., Fowler, R. A., Bhagwanjee, S. & Rubenfeld, G. D. Lancet 376, 1339–1346 (2010).

  3. 3.

    Rhee, C. et al. JAMA 318, 1241–1249 (2017).

  4. 4.

    Angus, D. C. & Poll, T.v. d. N. Engl. J. Med. 36, 840–851 (2013).

  5. 5.

    Hotchkiss, R. S. et al. Nat. Rev. Dis. Primers 2, 16045 (2016).

  6. 6.

    Kumar, A. et al. Crit. Care Med. 34, 1589–1596 (2006).

  7. 7.

    Vincent, J. L. et al. Intensive Care Med. 22, 707–710 (1996).

  8. 8.

    Singer, M. et al. JAMA 315, 801–810 (2016).

  9. 9.

    Taneja, I. et al. Sci. Rep. 7, 10800 (2017).

  10. 10.

    Ellett, F. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0208-z (2018).

  11. 11.

    Kolaczkowska, E. & Kubes, P. Nat. Rev. Immunol. 13, 159–175 (2013).

  12. 12.

    Hassan, U. et al. Nat. Commun. 8, 15949 (2017).

  13. 13.

    Skoutelis, A. et al. Crit. Care Med. 28, 2355–2359 (2000).

Download references

Author information

Affiliations

  1. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA

    • Umer Hassan
    • , Enrique Valera
    •  & Rashid Bashir
  2. Stevens Family Research Institute, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, USA

    • Umer Hassan
    • , Enrique Valera
    •  & Rashid Bashir

Authors

  1. Search for Umer Hassan in:

  2. Search for Enrique Valera in:

  3. Search for Rashid Bashir in:

Corresponding author

Correspondence to Rashid Bashir.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41551-018-0223-0

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing