Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

MICROBIAL ENGINEERING

Towards a cancer-chemopreventive diet

Commensal microbes engineered to convert natural compounds found in cruciferous vegetables into molecules with anticancer properties prevent carcinogenesis and cause the regression of colorectal cancer in mice fed with a vegetable diet.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Microbial engineering for the enhanced prevention and treatment of cancer.

References

  1. Song, M., Garrett, W. S. & Chan, A. T. Gastroenterology 148, 1244–1260 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. O’Keefe, S. J. Nat. Rev. Gastroenterol. Hepatol. 13, 691–706 (2016).

    Article  Google Scholar 

  3. Plottel, C. S. & Blaser, M. J. Cell. Host Microbe 10, 324–335 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Abreu, M. T. & Peek, R. M. Jr. Gastroenterology 146, 1534–1546 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rook, M. G. & Garrett, W. S. Nat. Rev. Immunol. 16, 341–352 (2016).

    Article  Google Scholar 

  6. Thomas, R. M. & Jobin, C. Trends Cancer 1, 24–35 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sinha, R. et al. PLoS ONE 11, e0152126 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Song, M. & Chan, A. T. Curr. Colorect. Cancer Rep. https://doi.org/10.1007/s11888-017-0389-y (2017).

  9. Ho, C. L. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0181-y (2018).

  10. Baron, J. A. et al. N. Engl. J. Med. 373, 1519–1530 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Baron, J. A. et al. N. Engl. J. Med. 340, 101–107 (1999).

    Article  CAS  PubMed  Google Scholar 

  12. Jiao, L. et al. J. Natl Cancer Inst. https://doi.org/10.1093/jnci/djx117 (2018).

  13. Toledo, E. et al. JAMA Intern. Med. 175, 1752–1760 (2015).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrew T. Chan.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Drew, D.A., Chan, A.T. Towards a cancer-chemopreventive diet. Nat Biomed Eng 2, 6–7 (2018). https://doi.org/10.1038/s41551-017-0186-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-017-0186-6

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer