Developing an eco-friendly, efficient, and highly selective gold-recovery technology is urgently needed in order to maintain sustainable environments and improve the utilization of resources. Here we report an additive-induced gold recovery paradigm based on precisely controlling the reciprocal transformation and instantaneous assembly of the second-sphere coordinated adducts formed between β-cyclodextrin and tetrabromoaurate anions. The additives initiate a rapid assembly process by co-occupying the binding cavity of β-cyclodextrin along with the tetrabromoaurate anions, leading to the formation of supramolecular polymers that precipitate from aqueous solutions as cocrystals. The efficiency of gold recovery reaches 99.8% when dibutyl carbitol is deployed as the additive. This cocrystallization is highly selective for square-planar tetrabromoaurate anions. In a laboratory-scale gold-recovery protocol, over 94% of gold in electronic waste was recovered at gold concentrations as low as 9.3 ppm. This simple protocol constitutes a promising paradigm for the sustainable recovery of gold, featuring reduced energy consumption, low cost inputs, and the avoidance of environmental pollution.
Gold, an indispensable element in human society from time immemorial, is widely used in currency and jewelry manufacture1, electronic fabrication2, medicine production3, and chemical synthesis4. Gold mining, however, is known notoriously to be one of the most environmentally destructive industries in today’s world. Massive amounts of cyanide5 and mercury6 are used to extract gold from ores each year, resulting in enormous waste streams contaminated with lethal cyanide and heavy metals, along with colossal amounts of carbon emissions and excessive energy consumption. In order to develop sustainable technologies for gold production and recovery, many alternative methods7, based upon the selective extraction or adsorption of gold from leaching solutions, have been developed. These methods include leaching electronic waste (e-waste) and gold ores with a single organic8,9,10,11,12/inorganic13 extraction reagent, or specific combinations14,15 of extraction reagents and organic solvents, not to mention the adsorption of ionic gold complexes with metal-organic frameworks16,17 and polymers18,19,20. As an alternative approach to extraction and adsorption, selective co-precipitation21,22,23,24 based on second-sphere coordination25,26 have proven increasingly popular for metal separations given their significant advantages—e.g., simple operation, ease of industrialization, minimal energy consumption, and zero hazardous emissions.
First-sphere coordination27, advanced in the early part of the 20th century by Nobel Laureate in Chemistry, Alfred Werner, refers to the coordinative bonding interactions between first-coordination sphere ligands and transition metals. Under the umbrella of supramolecular28,29 and host–guest30,31 chemistry, the investigation of second-sphere coordination32,33,34, which involves the noncovalent interactions between the first-sphere ligand and a macrocyclic molecule as the second-sphere ligand, has skyrocketed during the past several decades. In this context, many well-crafted macrocyclic receptors, e.g., crown ethers32, cyclodextrins35,36, calixarenes37, cucurbiturils38, and others39,40 have emerged as promising second-sphere coordination ligands, enabling the modulation of the chemical and physical properties of transition metal complexes. These macrocycles exhibit highly specific recognition for particular metal cationic complexes, including those containing Rh+ 41, Ru2+ 42, Gd3+ 43, and Yb3+ 44, as well as serve as anion receptors45,46,47 for negatively charged metal complexes, such as [ReO4]− 48, [CdCl4]2− 49, [PtCl6]2− 50, polyoxometalates51 and others52. The precise control of the assembly and reciprocal transformation of these second-sphere-coordinated adducts, however, remains challenging. Some of the second-sphere-coordinated adducts exhibit53 unique crystallinity, a property that paves the way for using second-sphere coordination to recycle precious metals from e-waste. Employing this protocol, we have separated54,55 gold from ores where α-cyclodextrin acts preferentially as a second-sphere coordinator for hydrated potassium tetrabromoaurate. When it comes to practical gold recovery, this protocol, however, still suffers from several limitations, including the fact that (i) a high content of gold ([KAuBr4] > 6 mM) in the leaching solution is required, (ii) additional potassium ions are mandatory, (iii) a high concentration of acid in the leaching solution prevents the formation of co-precipitates, (iv) gold-recovery efficiency is below 80% when performed at room temperature, and (v) the cost of α-cyclodextrin is relatively high. Hence, the development of more efficient and economic gold separation technology aligned with practical gold recovery is significant and necessary.
Herein, we demonstrate an additive-induced gold separation paradigm based on precisely controlling the reciprocal transformation of the second-sphere-coordinated adducts formed between β-CD and [AuBr4]− anions. Mechanistic investigations reveal that the additives drive rapid assembly of β-CD and [AuBr4]− anions by forcing the [AuBr4]− anions to move from the inner cavity to the primary faces of two β-CD tori, while the additives occupy the space between the secondary faces of the two β-CD tori, thus forming infinite one-dimensional supramolecular polymers that precipitate from aqueous solutions as cocrystals. A wide range of common organic solvents can be employed as additives. Solvents with high boiling points provide higher gold-recovery efficiencies. A gold-recovery efficiency of 99.8% has been achieved when dibutyl carbitol is used as the additive. The rapid cocrystallization is highly selective for [AuBr4]− anions, while no precipitate is observed when using metal cations along with other structurally similar anions, such as [PdBr4]2− and [PtBr4]2−. A laboratory-scale gold-recovery protocol, aligned with an attractive strategy for the practical recovery of gold metal, has been established, wherein 94% of gold is recovered directly from a leaching solution of gold-bearing scrap at gold concentrations as low as 9.3 ppm. In principle, this highly selective and fast cocrystallization procedure can be used for gold recovery from gold-bearing ores and e-waste.
Encapsulation KAuBr4 by β-cyclodextrin
Second-sphere coordination (Fig. 1a) of KAuBr4 with β-CD in aqueous solutions was investigated by 1H NMR spectroscopy. After adding an excess of KAuBr4 into a D2O solution of β-CD, all the protons on the β-CD show (Fig. 1b) notable changes in their chemical shifts. The resonances for protons H-1 and H-2 on the d-glucopyranosyl residues of β-CD show upfield shifts (Δδ = −0.03 and −0.03 ppm for H-1 and H-2), while the resonances for protons H-3, H-4, and H-5 on the D-glucopyranosyl residues undergo downfield shifts (Δδ = 0.05, 0.03 and 0.33 ppm for H-3, H-4, and H-5, respectively). Proton H-5 exhibits the largest downfield shift, while the resonance for proton H-6 separates into two sets of peaks, indicating that the [AuBr4]− anions are located near the primary face of β-CD. The binding affinity between β-CD and KAuBr4 in D2O was determined (Fig. 1c and Supplementary Figs. 10, 11) by 1H NMR titration. By tracking the changes in the chemical shift of H-5, the binding constant (Ka) between the [AuBr4]− anion and β-CD was determined (Fig. 1d) to be 4.47 × 104 M−1. The corresponding ΔG° value was calculated to be −6.3 kcal mol−1. Additionally, a strong peak with an m/z value of 1651.0059 was observed (Supplementary Fig. 18) in the high-resolution mass spectrum, corresponding to the 1:1 complex [[AuBr4]−⊂β-CD]−. Its isotopic pattern matches (Fig. 1e) well with the theoretical one, strongly supporting the formation of the host–guest complex in aqueous solutions.
The solid-state superstructure of the 1:1 complex was determined unambiguously by single-crystal X-ray diffraction analysis. Brown single crystals were obtained by slowly cooling an aqueous solution of KAuBr4 and β-CD from 90 °C to room temperature over 6 h. The [AuBr4]− anion, which is encapsulated (Fig. 1f) inside the cavity of β-CD, is located closer to the primary face (1°) of β-CD than to its secondary face (2°). The β-CD tori are distorted (Fig. 1f) elliptically and elongated along the [AuBr4]− plane. The lengths of the major and minor axes for the distorted β-CD tori are 13.9 and 12.6 Å, respectively. In the superstructure of the [AuBr4]−⊂β-CD complex, five of the H-5 protons on β-CD interact (Supplementary Fig. 1) closely with bromine atoms. The [C−H···Br−Au] distances (Supplementary Table 1) range from 3.0 to 3.4 Å. It is for this reason that the H-5 protons show the largest change in their chemical shift in the 1H NMR spectra. Three of the H-6 protons on β-CD also have close contact with the bromine atoms in the anion. The [C−H···Br−Au] distances (Supplementary Table 1) are 3.2−3.4 Å. These observations suggest that the [AuBr4]−⊂β-CD complex is stabilized by multiple weak [C−H···Br−Au] hydrogen-bonding interactions, aided and abetted by a hydrophobic effect overall. These noncovalent interactions were visualized (Fig. 1g and Supplementary Fig. 37) by an independent gradient model (IGM) analysis. All the results confirm the formation of second-sphere-coordinated KAuBr4⊂β-CD adducts in the solution and solid states.
Additive-induced supramolecular polymerization
Upon adding a trace amount of common organic solvents, which serve as additives, to a 1 M HBr aqueous solution of the KAuBr4⊂β-CD complex, brown co-precipitates form immediately. (Fig. 2a and Supplementary Movie 1). On the contrary, after mixing the same additives and β-CD with aqueous solutions of K2PdBr4 or K2PtBr4, which have lower binding affinities (1.45 × 102 and 33.3 M−1, respectively, Supplementary Figs. 12−15) with β-CD, no precipitation is observed (Fig. 2a). This observation establishes the fact that a trace amount of organic solvent can induce selective co-precipitation of the [AuBr4]−⊂β-CD complex, laying the foundation for developing a simple and effective gold-recovery technology. In order to verify the generality of this additive-induced co-precipitation behavior, various organic solvents and oils were added (Fig. 2b) to aqueous solutions of the KAuBr4⊂β-CD complex. Dibutyl carbitol (DBC), isopropyl ether (iPr2O), hexane, dichloromethane (CH2Cl2), chloroform (CHCl3), benzene and toluene can induce co-precipitation, while no precipitate was observed when diethyl ether, ethyl acetate, and other oils were used as additives. In order to quantify the yield of gold co-precipitates, UV−Vis absorption spectroscopy was performed. The characteristic absorption peaks for [AuBr4]− at 381 and 253 nm were used (Supplementary Figs. 19, 20) to determine the concentration of [AuBr4]− in the filtrates. The efficiencies of gold recovery for different samples were calculated based on the initial and residual concentrations of the [AuBr4]− anions in the aqueous solutions. We observed gold-recovery efficiencies ranging (Fig. 2b) from 27.0% to 99.8%, depending on the additives. It is worth noting that when DBC was used as the additive, the [AuBr4]− anions were almost entirely precipitated from aqueous solutions with a gold-recovery efficiency of 99.8%. This efficiency is much higher than that (78.3%) obtained in a previous method54 using α-CD. Gold-recovery efficiency was also optimized with respect to the amount of the additive. The results indicate that 0.1% (v/v) of DBC enables (Fig. 2c) a high gold precipitation yield of 99.7%. These observations suggest that DBC is the best candidate for gold recovery among all additives tested.
Filtration of the suspension, which was obtained upon the addition of DBC to an aqueous solution of the KAuBr4⊂β-CD complex, led to the isolation of a brown solid. The Fourier transform infrared (FTIR) spectrum of this solid reveals (Fig. 2d) sharp vibrational bands for the KAuBr4⊂β-CD complex at 1021 and 1152 cm−1, in addition to the characteristic vibration bands for DBC at 2864 and 2925 cm−1. These data confirm the formation of a ternary adduct between β-CD, KAuBr4, and DBC—namely, KAuBr4·DBC⊂2β-CD. In order to investigate the crystallinity of the KAuBr4·DBC⊂2β-CD adduct, powder X-ray diffraction (PXRD) analysis was performed. The PXRD pattern shows (Fig. 2e) a series of sharp diffraction peaks, indicating that the co-precipitate is a highly crystalline material. In the scanning electron microscopic (SEM) images (Fig. 2f, g) of the air-dried KAuBr4·DBC⊂2β-CD suspension, a plethora of angular rod-like microstructures with diameters in the range of several micrometers and lengths up to hundreds of micrometers were observed. SEM-equipped energy-dispersive X-ray spectroscopic (SEM-EDS) elemental maps uncover (Supplementary Fig. 34) a homogeneous distribution of the elements of carbon, oxygen, bromine, and gold throughout the microrods, confirming the formation of KAuBr4·DBC⊂2β-CD adducts. The thermogravimetric analysis (TGA) profile for the KAuBr4·DBC⊂2β-CD co-precipitate reveals (Supplementary Fig. 51a) that it begins to suffer mass loss at temperatures around 100 °C, most likely because of the loss of water of crystallization. Significant decomposition occurs around 160 and 280 °C, arising from halide release and the breakdown of β-CD. Finally, over 70 wt% of the original mass of the co-precipitate was lost at 800 °C. The TGA traces for the co-precipitates obtained by adding other additives behaved in a similar fashion (Supplementary Fig. 51b) to that of the KAuBr4·DBC⊂2β-CD adduct over the temperature range from 40 to 800 °C, indicating they have similar components.
Mechanism of additive-induced supramolecular polymerization
The mechanism for DBC-induced supramolecular polymerization has been elucidated by X-ray crystallography. Brown single crystals of the ternary complex formed between KAuBr4, β-CD, and DBC were obtained by slow vapor diffusion of DBC into an aqueous solution of KAuBr4 and β-CD over 3 days. Single-crystal X-ray diffraction analysis reveals that the [AuBr4]− anion is centered (Fig. 3a) between the primary faces of two adjacent β-CD tori. The H-5 protons on the primary faces of the two neighboring β-CD tori are close (Fig. 3b and Supplementary Fig. 3) to the four bromine atoms in the [AuBr4]− anion with [C−H···Br−Au] contacts ranging from 3.2 to 3.5 Å (Supplementary Table 2). All the H-6 protons on the two β-CD tori are in close contact with bromine atoms. The [C−H···Br−Au] distances range from 3.0 to 3.3 Å (Supplementary Table 2). The multiple [C−H···Br−Au] hydrogen-bonding interactions between the inward-facing H-5 and H-6 protons and the four bromine atoms constitute the major interactions anchoring the [AuBr4]− anions. Additionally, the bromine atoms in the [AuBr4]− interact (Fig. 3b) with DBC on account of a [C−H···Br−Au] hydrogen bond with a distance (Supplementary Fig. 3d) of 3.0 Å, while DBC occupies (Fig. 3a) the internal cavities of two neighboring β-CD tori. With the DBC serving as a connector and multiple intermolecular hydrogen bonds between the secondary faces, the two β-CD tori adopt (Fig. 3b) a head-to-head packing arrangement, forming a supramolecular dimer. Because the length (18.7 Å) of stretched-out DBC is much longer than the depth (13.2 Å) of the β-CD dimer, DBC adopts (Fig. 3a) a folded conformation inside the internal cavity of the dimer in order to maximize surface contacts. The folded DBC is sustained (Supplementary Fig. 3c) by two sets of [H−O···H−C] hydrogen bonds between the oxygen atoms on the secondary faces of the β-CD tori and the methylene hydrogens on DBC, as well as multiple Van der Waals interactions between inward-facing H-3 and H-5 protons on the β-CD tori and the carbon and hydrogen atoms in DBC. The two [H−O···H−C] distances were found (Supplementary Fig. 3c) to be 2.6 and 2.7 Å, while the distances associated with the Van der Waals interactions range (Supplementary Fig. 3c) from 2.1 to 2.9 Å. The β-CD tori undergo (Fig. 3a) elliptical deformations to accommodate the folded conformations of DBC, where the lengths of the major and minor axes for the distorted β-CD tori are 13.8 and 12.9 Å, respectively. It is worth mentioning that K+ ions are absent (Supplementary Fig. 3) in the crystal superstructures. A possible explanation is that protons replace K+ ions during crystallization. With the [AuBr4]− anions and DBC molecules as connectors, the β-CD tori are arranged (Fig. 3c) in a head-to-head and tail-to-tail manner extending along the c axis, forming an infinite one-dimensional (1D) supramolecular polymer. Bundles of these polymers are tightly packed as a result of intermolecular hydrogen bonds between the 1D columns, forming needle-like single crystals. The simulated PXRD pattern, derived from the single-crystal X-ray crystallographic data of HAuBr4·DBC⊂2β-CD, matches (Fig. 2e) well with the experimental one, indicating that the superstructure of the HAuBr4·DBC⊂2β-CD microcrystals obtained by solution-phase synthesis is consistent with its single-crystal X-ray diffraction analysis.
Based on the solid-state superstructures of [AuBr4]− and β-CD, obtained before and after adding DBC, we propose the mechanism (Fig. 3d) of additive-induced rapid cocrystallization and concomitant co-precipitation. In the aqueous solution of [AuBr4]− and β-CD, the primary species are the 1:1 [AuBr4]−⊂β-CD complex and free β-CD. After adding the hydrophobic DBC, it serves as an additional guest by co-occupying the binding cavity of two β-CD tori and forces the [AuBr4]− anions to move to the primary faces of the β-CD tori, forming a unique heterodimeric encapsulation complex. With DBC connecting the two secondary faces and [AuBr4]− anions linking two primary faces of the β-CD tori, the complexes assemble spontaneously into stable 1D supramolecular nanostructures. The ordered accumulation of these supramolecular nanostructures forms large needle-like nanocrystals.
Brown cocrystals of the HAuBr4·2(iPr2O)⊂2β-CD adduct were also obtained after layering iPr2O on top of an aqueous solution of the [AuBr4]−⊂β-CD complex for 12 h. X-Ray crystallography reveals that the HAuBr4·2(iPr2O)⊂2β-CD complex adopts (Supplementary Table 5) the same triclinic space group P1 as that of the HAuBr4·DBC⊂2β-CD complex. In its solid-state superstructure, the [AuBr4]− anions are located (Fig. 4b) between the primary faces of two β-CD tori, sustained by the multiple [C−H···Br−Au] interactions, an observation which is similar to that in the crystal superstructure of the HAuBr4·DBC⊂2β-CD complex. The DFT-calculated binding energy between β-CD and [AuBr4]− in the HAuBr4·2(iPr2O)⊂2β-CD cocrystal, however, is lower (Supplementary Fig. 47) than that in the HAuBr4·DBC⊂2β-CD cocrystal. Two iPr2O molecules are positioned (Fig. 4b) in the cavities and secondary faces of a β-CD dimer on account of intermolecular [C−H···O] hydrogen bonds and the hydrophobic effect. The binding energy between β-CD and iPr2O is much lower (Supplementary Fig. 49) than that between β-CD and DBC. With the [AuBr4]− anions and iPr2O located alternately at their primary and secondary faces, the β-CD tori are arranged (Supplementary Fig. 5e) repeatedly in the order head-to-head and tail-to-tail along the c axis. Notably, the space groups of the HAuBr4·2(iPr2O)⊂2β-CD cocrystals change (Supplementary Table 5) from triclinic P1 to monoclinic P21 after the cocrystals remain in their mother liquid for 3 days, indicating the crystals undergo (Fig. 4a) a cocrystal-to-cocrystal transformation. For convenience, the initial and transformed cocrystals are described as cocrystal A (Fig. 4b) and cocrystal B (Fig. 4c). In the solid-state superstructure of cocrystal B, only the [AuBr4]− anions and β-CD were observed (Fig. 4c), whereas iPr2O was absent. The [AuBr4]− anions are located (Fig. 4c and Supplementary Fig. 7) in the interspace between the primary faces of two β-CD tori, while the lattice space between the secondary faces of the two β-CD tori is occupied (Fig. 4c) by disordered H2O molecules. The disordered H2O molecules take over (Fig. 4a) the role of iPr2O, holding the two secondary faces of the β-CD tori together. The loss of iPr2O may be the reason for triggering the cocrystal transformation. Notably, the occupancy for the [AuBr4]− anions is (Fig. 4c) 50% in cocrystal B, while the [AuBr4]− anions achieve (Fig. 4b) full occupancy in cocrystal A, demonstrating half of the [AuBr4]− anions escape into solution during cocrystal transformation. The reason may be because of the lower binding energy (Supplementary Figs. 47, 48) between the central [AuBr4]− anions and their surrounding species in cocrystal B compared with cocrystal A.
The PXRD confirms the cocrystal-to-cocrystal transformation. The PXRD patterns of the co-precipitates, obtained by adding iPr2O to the mixture of β-CD and [AuBr4]− anions, change (Fig. 4d) over time. The HAuBr4·2(iPr2O)⊂2β-CD suspension, which settles at the bottom of vials after standing 0.5 h, was subjected to powder XRD analysis. Its PXRD pattern is consistent (Fig. 4d) with the simulated pattern based on the single-crystal X-ray data for HAuBr4·2(iPr2O)⊂2β-CD (cocrystal A), indicating that the co-precipitate possesses the same superstructure as cocrystal A. When the HAuBr4·2(iPr2O)⊂2β-CD suspension was allowed to stand at room temperature for 2.0, 24, and 48 h, the intensity of the feature peaks at 8.1° and 8.7° for cocrystal A became (Fig. 4d) lower and lower, while a set of new peaks appeared gradually at 7.2° and 9.4°. The PXRD pattern of the co-precipitates remained unchanged after standing for 2 days. The final pattern is analogous (Fig. 4d) to the simulation derived from the single-crystal X-ray crystallographic data for cocrystal B. These observations demonstrate that co-precipitates transform (Fig. 4a) spontaneously from cocrystal A to cocrystal B within 2 days. Combined with the solid-state superstructures of cocrystals A and B, we conclude that (i) iPr2O molecules, bound inside the cavity of β-CD, have been replaced by disordered H2O molecules during the cocrystal-to-cocrystal transformation, (ii) ∼50% of [AuBr4]− anions escape from the co-precipitates into aqueous solutions during the transformation. These observations may be the reason for the yield of gold-bearing co-precipitate obtained upon adding iPr2O being lower (Fig. 2b) than that upon adding DBC. According to PXRD patterns, the co-precipitates obtained by adding other low-boiling solvents, e.g., hexane, CH2Cl2, and CHCl3, also undergo (Supplementary Figs. 24−26) the cocrystal-to-cocrystal transformation over time, while the co-precipitates obtained on adding high-boiling solvents, e.g., DBC, benzene and toluene, exhibit (Supplementary Figs. 22, 27 and 28) no obvious changes over time. In the X-ray photoelectron spectra of the co-precipitates obtained by adding CH2Cl2 (Supplementary Fig. 29) and CHCl3 (Supplementary Fig. 30), the signal for chlorine is absent, confirming the loss of CH2Cl2 and CHCl3 during the cocrystal transformation. Additionally, the yields of gold-bearing co-precipitates, after adding high-boiling solvents, are much higher (Fig. 2b) than those upon adding low-boiling solvents, suggesting that the cocrystal-to-cocrystal transformation is unfavorable to gold recovery.
We believe that several factors need to be considered when choosing suitable additives to recover gold based on our results. They include—(i) Additives that should be hydrophobic and possess a relatively high binding affinity for β-CD, which is a prerequisite for them to participate in the co-assembly process. (ii) Additives should be size-matched with the cavity of β-CD and able to share the cavity together with the [AuBr4]− anion, which is essential for the formation of 1D supramolecular nanostructures. (iii) Additives with high boiling points are preferred when it comes to improving the stability of the cocrystals. (iv) Additives should be cheap and readily available, so as to reduce costs. (v) Additives should be eco-friendly, an attribute that is vital to sustainable development and environmental protection.
Gold recovery from gold-bearing scrap
In order to develop a feasible gold-recovery protocol based on additive-induced supramolecular polymerization, the influence of CD and gold salts on gold-recovery efficiency was also investigated. The β-CD-to-KAuBr4 ratio was optimized first of all. Six samples with different molar ratios of β-CD-to-KAuBr4 from 0.5 to 3 were prepared. After adding 0.1% (v/v) of DBC, all six clear solutions turned cloudy. The UV–Vis absorption spectra reveal (Fig. 5b) that the gold-recovery efficiencies, based on co-precipitates, increase gradually from 23.8% to 99.0% upon changing the molar ratio of β-CD-to-KAuBr4 from 0.5 to 3.0. Notably, the gold-recovery efficiency reaches a plateau when the molar ratios rise to (Fig. 5b) 2.5, suggesting that two β-CD tori are required to complex with each [AuBr4]− anion. γ-CD with a larger binding cavity and a lower binding affinity (1.39 × 103 M−1, Supplementary Figs. 16, 17) for [AuBr4]− anion was also investigated. The gold-recovery efficiencies based on γ-CD are much lower (Fig. 5c) than those obtained when using β-CD at the same CD-to-KAuBr4 molar ratio, indicating that β-CD is a better candidate for gold recovery than γ-CD.
The effect of the countercation of the gold salts on gold-recovery efficiency has also been investigated. After adding 0.1% (v/v) of DBC to the two aqueous solutions containing NaAuBr4⊂β-CD and HAuBr4⊂β-CD complexes, a large amount of brown co-precipitates was formed in both solutions. The corresponding gold-recovery efficiencies (Fig. 5d) are 97.5% (NaAuBr4) and 98.5% (HAuBr4), values which are almost identical to that (98.0%) for KAuBr4. This observation suggests that the additive-induced supramolecular polymerization is independent of the cation associated with the gold salts. Considering that the direct recovery of gold from the leaching solution at low concentration could be a challenge to the industry, we investigated the effect of the concentration of [AuBr4]− anions on gold-recovery efficiency. UV–Vis absorption spectra reveal (Supplementary Fig. 21) that over 91.5% of gold in the solutions can be precipitated when the concentration of KAuBr4 is ≥0.05 mM (9.3 ppm). This observation shows that the technology can be used to recover gold from leaching solutions at low concentrations. Compared with α-CD-based gold-recovery technology54, which requires high concentrations of KAuBr4 (>6 mM), the working concentration of [AuBr4]− anions in the current β-CD-based gold-recovery technology is reduced by a factor of 120.
The high performance of additive-induced cocrystallization between β-CD and [AuBr4]− motivated us to test the practicability of recovering gold from electronic scrap. A spent gold-bearing alloy cable was employed as a sample for developing a laboratory-scale gold-recovery protocol. The cable was etched (Fig. 5a) using a mixture solution of HBr and H2O2 to convert Au into HAuBr456. The acid concentration of the HAuBr4-containing solution was adjusted to 1 M. Insoluble impurities were removed by filtration. After adding an aqueous solution of β-CD and 0.1% (v/v) of DBC to the gold-bearing filtrate, yellow microcrystals formed (Fig. 5a) immediately.
In the X-ray photoelectron spectrum of the microcrystals, only the characteristic peaks of carbon, oxygen, bromine, and gold were observed (Fig. 5e), while signals for other metals were absent. The FTIR spectrum of the microcrystals matches (Supplementary Fig. 32) well with that of the HAuBr4·DBC⊂2β-CD cocrystal, indicating they have similar components. The similar PXRD patterns (Fig. 5f) between the microcrystals and the HAuBr4·DBC⊂2β-CD cocrystal demonstrate that the microcrystals obtained from the mixture possess the same solid-state superstructure as the HAuBr4·DBC⊂2β-CD cocrystal. These observations indicate that the additive-induced supramolecular polymerization between HAuBr4, DBC, and β-CD is highly selective and that the presence of large amounts of other metals has a negligible impact on the additive-induced crystallization process. SEM Analysis uncovers that the microstructure of the yellow microcrystals is similar to that of the HAuBr4·DBC⊂2β-CD adduct. Many microrods were observed (Supplementary Fig. 35) in the SEM images. SEM-EDS Revealed (Fig. 5h) that all the elements, including carbon, oxygen, bromine, and gold, were distributed uniformly in the microrods. The microscopic investigation and elemental analysis confirmed the high specificity of the co-crystallization. The ICP-MS analysis (Fig. 5g) indicated 99.0% of the [AuBr4]− anions are separated from the leaching solution at a concentration of 0.5 mM (93 ppm), a value which is close to the precipitation efficiency (99.8%) obtained when adding 0.1% (v/v) of DBC to a solution of the KAuBr4⊂β-CD complex. In order to demonstrate the applicability of the additive-induced supramolecular polymerization to recover a smaller amount of gold, two mixtures containing 9.3 and 4.7 ppm of gold were prepared. ICP-MS Analysis indicates (Fig. 5g) that 94.4% and 86.6% of the gold in them were precipitated. These results suggest that additive-induced polymerization can be used to recover the gold from low-grade gold ores and low-concentration gold-bearing electronic scrap. Finally, the gold metal was recovered from the yellow co-precipitate after reduction with N2H4·H2O. The β-CD can be recycled by precipitating with acetone and followed by recrystallization. Based on this laboratory-scale gold-recovery experiment, a gold-recovery flow diagram (Supplementary Fig. 52) has been proposed. The flow diagram provides us with a reference to develop a feasible protocol for recovering gold on a larger scale.
An eco-friendly and sustainable supramolecular metallurgical technology for gold recovery has been demonstrated. It is based on an additive-induced supramolecular polymerization of second-sphere coordinated adducts formed between β-cyclodextrin and tetrabromoaurate anions. The additives drive the assembly by obliging the tetrabromoaurate anions to move from the inner cavity to the primary face of two β-cyclodextrin tori, while themselves occupying the space between the secondary faces of two β-cyclodextrin tori, leading to the formation of infinite 1D supramolecular nanostructures that precipitate from the aqueous solutions as cocrystals. This additive-induced supramolecular polymerization, not only provides a feasible method for the rapid crystallization of the supramolecular polymers but also opens the door for regulating the assembly behavior of second-sphere coordinated adducts.
In contrast to the traditional antisolvent precipitation method, the additive-induced polymerization reported in this research provides the following advantages—(i) It only requires a small volume fraction (<0.3%) of additives to effectively precipitate the target compound with a high recovery efficiency (>99.5%). (ii) The additives do not have to be miscible with the solution. (iii) The molecular recognition-driven supramolecular polymerization is highly selective for the precipitation of target compounds in the presence of other structurally similar substrates.
From a practical viewpoint, this research describes a highly efficient and sustainable gold-recovery protocol. Compared with our previously reported54 protocol using α-cyclodextrin, the additive-induced polymerization with β-cyclodextrin comes with the following attributes—(i) The gold-recovery can be performed at a low concentration (9.3 ppm) with much better recovery efficiency (>94%). (ii) No additional potassium ions are needed. (iii) Co-precipitation can be performed directly in acidic leaching solutions without the need for neutralization. (iv) The cost of β-cyclodextrin is lower than that of α-cyclodextrin. In summary, our establishment of additive-induced polymerization constitutes an attractive strategy for the practical recovery of gold and leads to significantly reduced energy consumption, cost inputs, and environmental pollution. We are currently optimizing the strategy to recover gold from lower-concentration gold-bearing e-waste and exploring the generality of this strategy to separate other target metal ions.
The compounds HAuBr4 (99.9%, Alfa Aesar), NaAuBr4 (99.9%, Strem Chemicals), KAuBr4 (99.9%, Sigma), K2PdBr4 (98.0%, Strem Chemicals), K2PtBr4 (99.0%, Strem Chemicals), β-CD (>98.0%, Oakwood Chemical), γ-CD (>98.0%, Sigma), DBr (47 wt%, Sigma) in D2O, HBr (48 wt%, Sigma) in H2O, and H2O2 (30 wt%, Oakwood Chemical) in H2O were purchased from commercial suppliers and used without further purification. All the additives, i.e., dibutyl carbitol (DBC), isopropyl ether (iPr2O), diethyl ether (Et2O), hexane, ethyl acetate, dichloromethane (CH2Cl2), chloroform (CHCl3), benzene, toluene, olive oil, vegetable oil, and pump oil are commercially available. Ultra-pure water was generated by a Milli-Q system.
UV–Vis absorption spectroscopy
UV–Vis absorption spectra were recorded in 1 M HBr aqueous solutions at 298 K. UV–Vis absorption spectra were recorded on a UV-3600 Shimadzu spectrophotometer in rectangular quartz cells with light paths of 4 mm. Each gold-recovery experiment was duplicated independently, and the average gold-recovery efficiencies are presented with their standard deviations.
Fourier-transform infrared spectroscopy
Fourier-transform infrared (FT-IR) spectroscopy was performed on a Nexus 870 spectrometer (Thermo Nicolet) in the mode of attenuated total reflection (ATR) with the range from 4000 to 600 cm−1 and at a resolution of 0.125 cm−1.
High-resolution mass spectrometry
High-resolution mass spectrum (HRMS) for the host–guest complex was recorded on an Agilent 6210 Time-of-Flight (TOF) LC-MS with an ESI source.
NMR spectra were recorded on a Bruker Avance III 600 MHz spectrometer in D2O containing 0.5 M DBr. Chemicals shifts (δ) are given in ppm with residual H2O signals as a reference. 1H NMR Titrations: Highly-concentrated solutions of KAuBr4, K2PdBr4, or K2PtBr4 in D2O (containing 0.5 M DBr) as the titrating solution were added dropwise to a D2O solution (containing 0.5 M DBr) of β-CD or γ-CD. Binding constants were obtained by fitting a 1:1 isotherm according to the programs available at http://app.supramolecular.org/bindfit/.
Crystallization and single-crystal X-ray diffraction analyses
The KAuBr4⊂β-CD complex. Brown single crystals were obtained by slowly cooling an aqueous solution of KAuBr4 and β-CD from 90 °C to room temperature over 6 h. The HAuBr4·DBC⊂2β-CD complex: Brown single crystals were obtained by slow vapor diffusion of DBC into an aqueous solution of KAuBr4 containing 2 molar equivalents of β-CD over 3 days. The HAuBr4·2(iPr2O)⊂2β-CD complex (cocrystal A): Brown single crystals were obtained by slow liquid-liquid diffusion of iPr2O into an aqueous solution containing KAuBr4 and 2 molar equivalents of β-CD over 12 h. The 0.5(HAuBr4)⊂2β-CD complex (cocrystal B): Brown single crystals were obtained by allowing the HAuBr4·2(iPr2O)⊂2β-CD suspension to stand at room temperature for 3 days. The suitable crystals were mounted on a MITIGEN holder in Paratone oil on a Rigaku XtaLAB Synergy, Single source at home/near, HyPix diffractometer using CuKα (λ = 1.5418 Å) or MoKα (λ = 0.7107 Å) radiation. Data were collected using the Bruker APEX-II or Rigaku CrysAlis Pro program. The superstructures were solved with the ShelXT program using intrinsic phasing and refined with the ShelXL refinement package using least-squares minimization in OLEX2 software.
Powder X-ray diffraction analysis
Powder X-ray diffraction (PXRD) analyses were performed on an STOE-STADI MP powder diffractometer equipped with an asymmetrically curved germanium monochromator (Cu-Kα1 radiation, λ = 1.54056 Å) and a one-dimensional silicon strip detector (MYTHEN2 1K from DECTRIS). Samples for superstructural analysis were measured at room temperature in transmission mode. The simulated PXRD patterns were calculated using Mercury software 4.3.0.
X-ray photoelectron spectroscopy
X-ray photoelectron spectroscopic (XPS) analyses were conducted on a fully digital state-of-the-art X-ray photoelectron spectrometer (Thermo Scientific ESCALAB 250Xi), which was equipped with an electron flood gun and a scanning ion gun. The diameter of the X-ray spot was 500 μm, and the scan range was from 0 to 1200 eV.
Thermogravimetric analysis (TGA) experiments were performed on a Mettler Toledo TGA/DSC1 Stare System (Schwerzenbach, Switzerland) interfaced with a PC using Stare software. Samples were placed in an Al2O3 crucible and heated at a rate of 15 K min−1 from 40 to 800 °C under a helium atmosphere.
Inductively coupled plasma mass spectrometry
ICP-MS was performed on a computer-controlled (QTEGRA software) Thermo iCapQ ICP-MS (Thermo Fisher Scientific, Waltham, MA, USA) operating in STD mode and equipped with an ESI SC-2DX PrepFAST autosampler (Omaha, NE, USA). The internal standard was added inline using the prepFAST system and consisted of 1 ng/mL of a mixed-element solution containing Bi, In, 6Li, Sc, Tb, Y (IV-ICPMS-71D from Inorganic Ventures). Online dilution was also carried out by the prepFAST system and used to generate a calibration curve consisting of 100, 50, 20, 10, 5, and 1 ppb Au. Each sample was acquired using one survey run (10 sweeps) and three main (peak jumping) runs (40 sweeps). The isotopes selected for analysis were 197Au, 89Y, 115In, 159Tb, and 209Bi (chosen as internal standards for data interpolation and machine stability). Instrument performance was optimized daily by auto-tuning, followed by verification with the aid of a performance report.
Scanning electron microscopy
Scanning electron microscopic (SEM) images were obtained on a SU8030 scanning electron microscope at the voltages of 10/15 kV, while the energy-dispersive X-ray spectroscopy (EDS) elemental maps were recorded at 15 kV.
Density functional theory calculations
The superstructures from the single-crystal X-ray diffraction were used for the density functional theory (DFT) calculations in the Orca program (version 4.1.2) using the hybrid generalized gradient approximation (GGA) Becke three-parameter Lee-Yang-Parr (B3LYP) functional, the Ahlrichs double-zeta basis set with a polarization function Def2-SVP, and Grimme’s third-generation atom-pairwise dispersion correction with Becke Johnson damping (D3BJ); an integration grid of four was used throughout. To further speed up the DFT optimizations, the Coulomb integral and numerical chain-of-sphere integration for the HF exchange (RIJCOSX) method was applied with the Def2/J auxiliary basis.
Additive-induced ternary cocrystallization experiments
Aqueous stock solutions of KAuBr4 were prepared by dissolving directly the corresponding commercially available salt in an aqueous HBr (2 M) solution, while an aqueous solution of β-CD was prepared by dissolving the β-CD powder in ultra-pure water. The addition of 2 molar equivalents of β-CD (1 mL, 10 mM) to a KAuBr4 (1 mL, 5 mM) aqueous solution led to the formation of a 1:1 KAuBr4⊂β-CD complex. When specific additives (0.1% v/v) were added to the resulting aqueous solutions, yellow suspensions were formed immediately. The yellow solids were isolated by filtration, washed, and air-dried. The concentrations of [AuBr4]− remaining in the filtrates were determined by UV–Vis absorption spectroscopy or ICP-MS analysis. The metal precipitation yields were calculated based on the aqueous solution’s initial and residual concentrations of metal anions.
Gold recovery from scrap
A gold-bearing cable was obtained from the local electronic junk shop. The yellow cable (15 mg) was first leached with a mixture of HBr and H2O2 overnight. Subsequently, the acid concentration in the HAuBr4-containing leaching solution was adjusted to 1 M with ultra-pure H2O, and the insoluble impurities were removed by filtration. A saturated aqueous solution of β-CD containing ∼1 M HBr was added to the leaching solution, forming the HAuBr4⊂β-CD complex. Upon adding 0.1% (v/v) of DBC, the solution became gradually cloudy. After stirring for 5 min, the co-precipitate of HAuBr4·DBC⊂2β-CD was separated from other metals by filtration and washed with ultra-pure H2O. The metals trapped in the co-precipitates were analyzed by ICP-MS by comparing them with the metal concentrations of the solution before and after adding DBC. In order to convert the [AuBr4]− anions trapped in the co-precipitate to gold metal, the HAuBr4·DBC⊂2β-CD co-precipitates were dispersed in an aqueous solution and reduced with N2H4·H2O. After centrifugation and washing with H2O to dissolve the residual β-CD, gold metal was obtained. β-CD, which dissolves in the aqueous solution, can be recycled by precipitating with acetone and followed by recrystallization.
All the data supporting the conclusions are included in this article and its Supplementary files. Raw data are available from corresponding authors upon request. Crystallographic data for the structures reported in this Article have been deposited at the Cambridge Crystallographic Data Centre, under deposition numbers CCDC 2206843 (KAuBr4⊂β-CD), 2206844 (HAuBr4•DBC⊂2β-CD), 2206845 (HAuBr4·2(iPr2O)⊂2β-CD), and 2206846 (0.5(HAuBr4)⊂2β-CD). Copies of the data can be obtained free of charge via https://www.ccdc.cam.ac.uk/structures/. Checkcif files (Supplementary Data 1−4) for the four crystals are attached. A real-time video (Supplementary Movie 1) recording of the formation of co-precipitates between KAuBr4 and β-CD when adding DBC is attached in the form of an individual Supplementary MP4 file.
Brody, H. Gold. Nature 495, S1 (2013).
Chen, Y. S., Hong, M. Y. & Huang, G. S. A protein transistor made of an antibody molecule and two gold nanoparticles. Nat. Nanotechnol. 7, 197–203 (2012).
Weintraub, K. Biomedicine: the new gold standard. Nature 495, S14–S16 (2013).
Zhong, D. et al. Linear alkane polymerization on a gold surface. Science 334, 213–216 (2011).
McGivney, E. et al. Biogenic cyanide production promotes dissolution of gold nanoparticles in soil. Environ. Sci. Technol. 53, 1287–1295 (2019).
Veiga, M. M. et al. Mill leaching: a viable substitute for mercury amalgamation in the artisanal gold mining sector? J. Clean. Prod. 17, 1373–1381 (2009).
Chen, Y., Qiao, Q., Cao, J., Li, H. & Bian, Z. Precious metal recovery. Joule 5, 3097–3115 (2021).
Burdinski, D. & Blees, M. H. Thiosulfate- and thiosulfonate-based etchants for the patterning of gold using microcontact printing. Chem. Mater. 19, 3933–3944 (2007).
Cho, E. C., Xie, J., Wurm, P. A. & Xia, Y. Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant. Nano Lett. 9, 1080–1084 (2009).
Doidge, E. D. et al. A simple primary amide for the selective recovery of gold from secondary resources. Angew. Chem. Int. Ed. 55, 12436–12439 (2016).
Lee, H., Molstad, E. & Mishra, B. Recovery of gold and silver from secondary sources of electronic waste processing by thiourea leaching. JOM 70, 1616–1621 (2018).
Li, F. et al. Highly efficient and selective extraction of gold by reduced graphene oxide. Nat. Commun. 13, 4472 (2022).
Chen, Y. et al. Selective recovery of precious metals through photocatalysis. Nat. Sustain. 4, 618–626 (2021).
Lin, W., Zhang, R. W., Jang, S. S., Wong, C. P. & Hong, J. I. “Organic aqua regia”—powerful liquids for dissolving noble metals. Angew. Chem. Int. Ed. 49, 7929–7932 (2010).
Yue, C. et al. Environmentally benign, rapid, and selective extraction of gold from ores and waste electronic materials. Angew. Chem. Int. Ed. 56, 9331–9335 (2017).
Mon, M. et al. Selective gold recovery and catalysis in a highly flexible methionine-decorated metal-organic framework. J. Am. Chem. Soc. 138, 7864–7867 (2016).
Sun, D. T., Gasilova, N., Yang, S., Oveisi, E. & Queen, W. L. Rapid, selective extraction of trace amounts of gold from complex water mixtures with a metal-organic framework (MOF)/polymer composite. J. Am. Chem. Soc. 140, 16697–16703 (2018).
Yang, F. et al. Rapid capture of trace precious metals by amyloid-like protein membrane with high adsorption capacity and selectivity. J. Mater. Chem. A. 8, 3438–3449 (2020).
Hong, Y. et al. Precious metal recovery from electronic waste by a porous porphyrin polymer. Proc. Natl. Acad. Sci. USA 117, 16174–16180 (2020).
Hong, Y., Rozyyev, V. & Yavuz, C. T. Alkyl‐linked porphyrin porous polymers for gas capture and precious metal adsorption. Small Sci. 1, 2000078 (2021).
Dong, C.-C., Xiang, J.-F., Xu, L.-J. & Gong, H.-Y. MCl4n− (AuCl4−, PtCl42−, or PdCl42−) anion extraction from NanMCl4 in water using a tetraimidazolium macrocyclic receptor. Tetrahedron Lett. 59, 264–267 (2018).
Kinsman, L. M. M., Ngwenya, B. T., Morrison, C. A. & Love, J. B. Tuneable separation of gold by selective precipitation using a simple and recyclable diamide. Nat. Commun. 12, 6258 (2021).
Shaffer, C. C., Liu, W., Oliver, A. G. & Smith, B. D. Supramolecular paradigm for capture and co-precipitation of gold(III) coordination complexes. Eur. J. Chem. 27, 751–757 (2021).
O’Connell-Danes, J. G., Ngwenya, B. T., Morrison, C. A. & Love, J. B. Selective separation of light rare-earth elements by supramolecular encapsulation and precipitation. Nat. Commun. 13, 4497 (2022).
Harada, A. & Takahashi, S. Preparation and properties of cyclodextrin–ferrocene inclusion complexes. J. Chem. Soc. Chem. Commun. 645−646 (1984).
Colquhoun, H. M., Stoddart, J. F. & Williams, D. J. Second-sphere coordination—a novel role for molecular receptors. Angew. Chem. Int. Ed. Engl. 25, 487–507 (1986).
Werner, A. Neuere Anschauungen Auf dem Gebiete der Anorganischen Chemie (Vieweg, Braunschweig, 1913).
Lehn, J.-M. Supramolecular chemistry—scope and perspectives molecules, supermolecules, and molecular devices (Nobel lecture). Angew. Chem. Int. Ed. Engl. 27, 89–112 (1988).
Pedersen, C. J. The discovery of crown ethers (Nobel lecture). Angew. Chem. Int. Ed. Engl. 27, 1021–1027 (1988).
Cram, D. J. The design of molecular hosts, guests, and their complexes. (Nobel lecture). Angew. Chem. Int. Ed. Engl. 27, 1009–1020 (1988).
Yu, G., Jie, K. & Huang, F. Supramolecular amphiphiles based on host–guest molecular recognition motifs. Chem. Rev. 115, 7240–7303 (2015).
Steed, J. W. First- and second-sphere coordination chemistry of alkali metal crown ether complexes. Coord. Chem. Rev. 215, 171–221 (2001).
Liu, Z., Schneebeli, S. T. & Stoddart, J. F. Second-sphere coordination revisited. Chimia 68, 315–320 (2014).
Liu, W., Das, P. J., Colquhoun, H. M. & Stoddart, J. F. Whither second-sphere coordination? CCS Chem. 4, 755–784 (2022).
Harada, A. & Takahashi, S. Preparation and properties of inclusion compounds of transition metal complexes of cyclo-octa-1,5-diene and norbornadiene with cyclodextrins. J. Chem. Soc., Chem. Commun. 1229−1230 (1986).
Prochowicz, D., Kornowicz, A. & Lewinski, J. Interactions of native cyclodextrins with metal ions and inorganic nanoparticles: fertile landscape for chemistry and materials science. Chem. Rev. 117, 13461–13501 (2017).
Beer, P. D., Drew, M. G. B. & Ogden, M. I. First- and second-sphere coordination of a lanthanum cation by a calixarene tetraamide in the partial-cone conformation. J. Chem. Soc. Dalton Trans. 1489−1492 (1997).
Chen, L. X. et al. Outer surface interactions to drive cucurbituril-based supramolecular frameworks: possible application in gold recovery. Chem. Commun. 55, 14271–14274 (2019).
Liu, W., Oliver, A. G. & Smith, B. D. Macrocyclic receptor for precious gold, platinum, or palladium coordination complexes. J. Am. Chem. Soc. 140, 6810–6813 (2018).
Nelson, J. J. M. & Schelter, E. J. Sustainable inorganic chemistry: metal separations for recycling. Inorg. Chem. 58, 979–990 (2019).
Bender, T. A., Bergman, R. G., Raymond, K. N. & Toste, F. D. A supramolecular strategy for selective catalytic hydrogenation independent of remote chain length. J. Am. Chem. Soc. 141, 11806–11810 (2019).
Luis, E. T., Day, A. I., Konig, B. & Beves, J. E. Photophysical activity and host-guest behavior of ruthenium polypyridyl catalysts encapsulated in cucurbituril. Inorg. Chem. 59, 9135–9142 (2020).
Simke, J. et al. Photoresponsive host–guest chemistry and relaxation time of fluorinated cyclodextrin and arylazopyrazole-functionalized DOTA metal complexes. Org. Biomol. Chem. 19, 2186–2191 (2021).
Thuery, P. Lanthanide complexes with cucurbit[n]urils (n = 5, 6, 7) and perrhenate ligands: new examples of encapsulation of perrhenate anions. Inorg. Chem. 48, 4497–4513 (2009).
Ji, X., Chi, X., Ahmed, M., Long, L. & Sessler, J. L. Soft materials constructed using calixpyrrole- and “Texas-sized” box-based anion receptors. Acc. Chem. Res. 52, 1915–1927 (2019).
Chen, L. J., Berry, S. N., Wu, X., Howe, E. N. W. & Gale, P. A. Advances in anion receptor chemistry. Chem 6, 61–141 (2020).
Zhao, W., Flood, A. H. & White, N. G. Recognition and applications of anion–anion dimers based on anti-electrostatic hydrogen bonds (AEHBs). Chem. Soc. Rev. 49, 7893–7906 (2020).
Katayev, E. A. et al. Bipyrrole- and dipyrromethane-based amido-imine hybrid macrocycles. New receptors for oxoanions. J. Org. Chem. 72, 2886–2896 (2007).
Ni, X. L. et al. Self-assemblies based on the “outer-surface interactions” of cucurbit[n]urils: new opportunities for supramolecular architectures and materials. Acc. Chem. Res. 47, 1386–1395 (2014).
Wu, H. et al. Selective separation of hexachloroplatinate(IV) dianions based on exo-binding with cucurbituril. Angew. Chem. Int. Ed. 60, 17587–17594 (2021).
Fang, X., Kogerler, P., Isaacs, L., Uchida, S. & Mizuno, N. Cucurbit[n]uril-polyoxoanion hybrids. J. Am. Chem. Soc. 131, 432–433 (2009).
Mercer, D. J. & Loeb, S. J. Metal-based anion receptors: an application of second-sphere coordination. Chem. Soc. Rev. 39, 3612–3620 (2010).
Colquhoun, H. M., Lewis, D. F., Stoddart, J. F. & Williams, D. J. Crown ethers as second-sphere ligands. The interactions of transition-metal ammines with 18-crown-6 and dibenzo-18-crown-6. J. Chem. Soc. Dalt. Trans. 607−613 (1983).
Liu, Z. et al. Selective isolation of gold facilitated by second-sphere coordination with α-cyclodextrin. Nat. Commun. 4, 1855 (2013).
Liu, Z. et al. Cation-dependent gold recovery with a-cyclodextrin facilitated by second-sphere coordination. J. Am. Chem. Soc. 138, 11643–11653 (2016).
Hojo, M., Iwasaki, S. & Okamura, K. Pure gold dissolution with hydrogen peroxide as the oxidizer in HBr or HI solution. J. Mol. Liq. 246, 372–378 (2017).
The authors thank Northwestern University (NU) for their support of this research, which made use of the IMSERC X-Ray facility at NU. It receives backing from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205) and NU. H.W., L.O.J., W.L., G.C.S., and J.F.S. also acknowledge the strong support provided by the Center for Sustainable Separations of Metals (CSSM), a National Science Foundation (NSF) Center for Chemical Innovation (CCI), grant number CHE-1925708. Theoretical investigations were supported in part by the computational resources and staff contributions provided by the NU Quest High-Performance Computing Facility, which is jointly supported by the Office of the Provost, the Office for Research, and Northwestern University Information Technology.
The authors declare no competing interests.
Peer review information
Nature Communications thanks Francesco Trotta and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Wu, H., Wang, Y., Tang, C. et al. High-efficiency gold recovery by additive-induced supramolecular polymerization of β-cyclodextrin. Nat Commun 14, 1284 (2023). https://doi.org/10.1038/s41467-023-36591-0
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.