Abstract
Polyketide oligomers containing the structure of tetracyclic isochroman comprise a large class of natural products with diverse activity. However, a general and stereoselective method towards the rapid construction of this structure remains challenging due to the inherent instability and complex stereochemistry of polyketide. By mimicking the biosynthetic pathway of this structurally diverse set of natural products, we herein develop an asymmetric hetero-Diels–Alder reaction of in-situ generated isochromene and ortho-quinonemethide. A broad range of tetracyclic isochroman frameworks are prepared in good yields and excellent stereoinduction (up to 95% ee) from readily available α-propargyl benzyl alcohols and 2-(hydroxylmethyl) phenols under mild conditions. This direct enantioselective cascade reaction is achieved by a Au(I)/chiral Sc(III) bimetallic catalytic system. Experimental studies indicate that the key hetero-Diels-Alder reaction involves a stepwise pathway, and the steric hindrance between in-situ generated isochromene and t-Bu group of Sc(III)/N,N’-dioxide complex is responsible for the enantioselectivity in the hetero-Diels–Alder reaction step.
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Introduction
Tetracyclic isochromans, a type of polyketide oligomers1,2,3, are ubiquitously present in numerous natural products and bioactive molecules. For instance, Chaetophenol D was induced from chemically mediated epigenetic manipulation of fungal gene expression, exhibiting excellent anti-adenovirus activity4. Indigotide C and its isomer were biosynthesized by cultivation of Cordyceps indigotica, an entomopathogenic fungus, in the presence of suberoyl bis-hydroxamic acid, exhibiting good antibacterial activity5 (see Fig. 1a). Thus, the development of a general and stereoselective method towards a rapid construction is highly desirable. However, to our knowledge, such an effient methodology has not yet been established so far6, probably due to the inherent instability of tetracyclic isochroman polyketide and the difficulties in controlling the complex stereochemistry.
As an important intermidiate, ortho-quinone methide (o-QM) has caught much attention in the field of asymmetric catalysis7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26. Moreover, this highly reactive specie was proposed to be the diene intermidiate in the biosynthesis of several polyketide natural products via hetero-Diels–Alder (HDA) reaction. Asai and Oshima speculated a biosynthetic route of Indigotide C involving isochromene and o-QM intermidiates5. The same group developed a biosynthetic approach for the construction of a pseudo-natural fungal polyketide A by using 1 as substrate in 201527 (see Fig. 1b). The key of this method also lies in a HDA reaction of isochromene and o-QM which were heterologously biosynthesized by introducing the NR-PKS-encoding gene into Aspergillus oryzae. Inspired by this possible biosynthetic route of poliketide oligomer, we decided to exploit an artificial asymmetric catalytic system from the similar intermediates to build this complex structure. To the best of our knowledge, it is worth noting that there has been no report of biomimetic asymmetric catalytic HDA reaction involving o-QMs intermediates. The development of biomimetic HDA route for the synthesis of core structure of these natural products is of great significance to not only understand biosynthetic HDA reactions involving o-QM intermediates, but also expand the limitation of substrates catalyzed by Diels–Alderase enzymes28,29,30,31,32,33,34. The establishment of the enantioselective biomimetic polyketide oligomer synthesis requires the methods for the generation of isochromene and o-QM intermidiates and a catalyst capable of promoting the stereoselective HDA reaction. It is known that Au(I) complexes have been used in the cascade reactions35,36,37,38,39 and could promote the intramolecular cyclization of benzyl alcohol-functionalized alkynes to isochromene intermediate40,41, and the o-QM intermidiate could be generated from the proper precursor in the presence of either acid or base.
Recently, Au/Lewis acid bimetallic catalysis has been exploited to be a strategy to construct aminals and ketals via 5-exo-dig cyclization of alkynyl amides or alcohols and relay cycloaddition reactions with electrophiles42,43,44,45,46,47,48,49. Moreover, Feng’s group developed the first highly efficient asymmetric bimetallic Au(I)/chiral Ni(II) catalytic cascade reaction of α, β-unsaturated γ-keto esters with alkynyl amides and alcohols for the synthesis of spiroketals and spiroaminals in 201650. Kang and coworkers realized the same reaction by employing a Au(I)/chiral Rh(III) catalytic system two years later51. Inspired by these elegant works, we envisioned that a combination of a Au(I) catalyst and a chiral lewis acid catalyst might enable the HDA reaction of in-situ generated isochromene and o-QM to deliver the optically active tetracyclic isochromans, despite of that the acceptors of reported asymmetric Au/Lewis acid bimetallic catalysis were limited to α, β-unsaturated γ-keto esters, and the most of known asymmetric cascade reactions of alkynyl alcohols delivered spiro products rather than fused products50,52,53,54,55,56,57,58,59,60,61.
In this work, we found a highly efficient Au(I)/chiral Sc(III) bimetallic catalytic system which could achieve asymmetric HDA reaction of in-situ generated isochromene and ortho-quinonemethide (o-QM), and provided a diversity of tetracyclic isochromans in moderate to high yields and with high levels of diastereoselectivities and enantioselectivities (up to 95% ee) (see Fig. 1c).
Results and discussion
Studies commenced by screening effective precursors of o-QMs and the corresponding catalysts. We selected α-propargyl benzyl alcohol 3a as model substrate and JohnphosAu as the catalyst to generate isochromene intermidiate. 2-(Hydroxylmethyl) phenol 2a was chosen as the precursor of o-QM. Representative Lewis acids and Brønsted acids were investigated in the presence of 1.2 equivalent 3a and JohnphosAu catalyst (see the Supporting Information, Table S2). Sc(OTf)3 was found to be the only efficient catalyst for this reaction, affording the HDA product 4a in 65% yield with 3/1 d.r. (Fig. 2, entry 1). Subsequently, a series of other noble metal complexes such as Pd(II), Ag(I) and Au(I) complex were evaluated to generate isochromene intermidiate, but only (acetonitrile)Au-complex delivered the desire HDA products in good yield and no product was obtained by in-situ formed Au-complex (see the Supporting Information, table S2). Next, the screening of different types of chiral ligands for the purpose of achieving the asymmetric version of this reaction suggested that Feng ligands (N,N’-dioxide) showed unique activities in the asymmetric HDA reaction of in-situ generated isochromenes and o-QMs (Fig. 2, entries 2-7). The use of (S)-proline derived L-PrPr2 resulted in lower diastereoselectivities and enantioselectivities than (S)-piperidine derived L-PiPr2 (Fig. 2, entry 2 VS entry 4). More sterically hindered substituents at the para positions of aniline were beneficial to improve both diastereoselectivities and ee values (Fig. 2, entries 5 and 7 VS entries 2 and 3) and aniline derived L-PiMe2t-Bu resulted in higher ee values than amantadine derived L-PiAd (Fig. 2, entry 6 VS entry 7). The solvent screening suggested that the catalytic reactions were available in chlorinated solvents and DCM gave the best yield and selectivity (Fig. 2, entries 7-9). Notably, after cooling to 6 °C, the ee value of the HDA product 4a was increased to 91% with little drop of yield (Fig. 2, entry 10). Therefore, the optimized conditions involved the use of L-PiMe2t-Bu/Sc(OTf)3 and JohnphosAu as catalysts in DCM at 6 °C (Fig. 2, entry 10).
Under optimized reaction conditions, the substrates scope of the reaction was examined. A series of aryl-substituted ortho-hydroxybenzyl alcohols 2a-i were tested with 3a as model α-propargyl benzyl alcohol (Fig. 3). Pleasingly, either electron-donating or electron-withdrawing substituents at the para- or meta-position of the benzene ring (2a-g) were well tolerated, affording the corresponding poliketide oligomers in moderate yields and with good to excellent diastereoselectivities and enantioselectivities. In particular, the reactions of o-QMs with 2-naphthyl and 4-biphenyl substituents successfully afforded the desired products (4h,i) in 76% and 60% yield with 90% and 84% ee respectively. However, ortho-substituted aryl groups have an extremely detrimental effect on the reactivity of this reaction probably due to the steric hinder effect. On the other hand, substituents at the quinone methide fragment were tolerated as well, and the corresponding adducts 4j-o were obtained in good to excellent enantioselectivities (81–89% ee). Notably, alkyl-substituted o-QMs were also demonstrated to be acceptors amenable to the reaction protocol, giving rise to the corresponding products 4p-q with enantioselectivities up to 75% ee. However, a variety of ortho-aminobenzyl alcohols could not afford the desired product probably due to the low reactivity of aza-o-quinone methide. The absolute configuration of 4l was determined to be (S,S,S) on the basis of single crystal X-ray diffraction analysis.
Subsequently, we turned our attention to the substrates scope of α-propynyl benzyl alcohols by using o-QM precursor 2 h as substrate. As shown in Fig. 4, a wide range of α-propynyl benzyl alcohols 3b-i bearing different substituted aryl groups reacted with 2 h quite well to form the corresponding poliketide oligomers 4r-4y in good to moderate yields (43–72%) with excellent ee values (89–95%). In general, electron-donating groups furnished the poliketides 4r and 4s in higher yields than those with electron-withdrawing substituents 4t-y, albeit in similarly high ee values. Cbz-protected α-propargyl benzyl amine 3j as well as various alkyl benzyl alcohol derivatives 3k-q was investigated in this cascade reaction under the optimized reaction conditions. 3j reacted with 2h quite well to form the corresponding N-aza poliketide oligomer 5a in 63% yield, 1.5:1 d.r with 22% ee for major diastereoisomer and 15% ee for minor diastereoisomer. The reactions between 2h and α-ethynyl benzyl alcohols 3k-l were carried out with L-PiAd as ligand and chiral spiro products 5b-c were isolated in 72–76% yield and 52–55% ee. 2-(Propynyl)phenol 3m was also tolerated as well under the standard reaction condition and gave the corresponding chiral spiro product 5d in 31% yield with 37% ee. Moreover, alkyl benzyl alcohol 3o reacted with 2h to form the product 5f by 1,4-addition without annulation in 8 membered ring system likely due to the ring strain. It is worth mentioning that the reaction between 3n and 2h was messy toward 7 membered ring system and poliketide oligomer 5e was isolated in 14% yield with 0% ee. Internal alkynes 3p-q were also demonstrated to be reactants amenable to the reaction protocol, giving rise to the corresponding products 5g-h in 39–41% yield with 53–55% ee. Hexynols 3s-t are unavailable substrates in this catalytic system. However, pentynol derivative 3r reacted quite well with 2h to form the chiral spiro product 5i in 52% yield with 66% ee.
To evaluate the synthetic potential of this protocol, the cascade reaction of 2h and 3a was carried out on a gram scale under optimized reaction conditions with Au(I)/N,N′-dioxide-Sc(ΙΙΙ) complex. The corresponding product, tetracyclic isochroman poliketide oligomer 4h, could be obtained with 52% yield, 9:1 d.r. and 90% ee (Fig. 5a). In addition, derivatizations of product 4 were performed without loss of enantiopurity of the functionalized products. For example, the controllable selective cleavages of C-O bonds in poliketide 4d were carried out without any deterioration of enantiopurity (Fig. 5b). In the presence of strong Lewis acid BF3•OEt, 4d was readily cleaved to the corresponding oxonium ion to furnish bioactive compound 6 which was reported to be an estrogen receptor degrader for treatment of ER+ breast cancers with good yield and complete diastereocontrol (Fig. 5b, black part). If TiCl4 was used as strong Lewis acid instead of BF3•OEt, 4d was readily transformed to another oxonium ion and phenol 7 was obtained (Fig. 5b, blue part). Considering the structure of tetracyclic isochroman natural product, 8r (R = H) as a precursor of o-QM was tested in the asymmetric reaction with 2a, but no product was obtained. Unexpectedly, TMS substituted ortho-hydroxybenzyl alcohol 8s gave the product 9a with the skeleton of natural product directly under standard conditions in 90% ee albeit with somewhat eroded yield (Fig. 5c).
As a key step toward establishing the basis for diastereo- and enantiocontrol in this cascade reaction of 1-(hydroxymethyl)-2-phenols 2 and α-propargyl benzyl alcohols 3 with the catalysis of Sc(ΙΙΙ)/Au(I), we endeavored to determine whether the HDA reaction of in-situ generated isochromene and ortho-quinonemethide proceeds via a concerted or stepwise pathway. To address this question, we investigated the carbon isotope effects for the [4 + 2] reaction between 2b and 3a using Singleton’s method at natural abundance62,63. When the reaction was stopped at 71% conversion, the 13C ratio of each carbon in the recovered 3-methyl-1H-isochromene 10 to the same carbon in virgin 10 was measured using quantitative 13C NMR. As shown in Fig. 6, the only appreciable carbon isotope effect was observed at the 4-C-position of 10, thus indicating that the HDA cycloaddition might proceed through a stepwise mechanism to form adducts.
In order to investigate the role of the Au-complex in this enantioselective cascade reaction, we investigated the hetero-Diels-Alder reaction between o-QMs precursor 2b and 3-methyl-1H-isochromene 10 with or without the participation of Au-complex (Fig. 7, entry 2 and 3). Two catalytic reactions afforded the tetracyclic isochroman poliketide oligomer 4b in similar yield, d.r. and ee values comparing to the cascade reaction between 2b and 3a (Fig. 7, entry 1), which suggests that 10 may be the real active intermediate in the [4+2] cycloaddition and Au-complex may not participate in the control of the enantioselectivity.
Based on the reported X-ray structure of the N,N’-dioxide ScIII complex64 and the absolute configuration of the product 4 as well as the results of control experiments, we proposed a catalytic model for the Au/Sc*catalyzed HDA reaction (Fig. 8). A complex with octahedral geometry as the transition state is formed by coordinating L-PiMe2t-Bu and o-QMs to ScIII center. The enol attack takes place from the less hindered Si face of the o-QMs to form the first chiral center in the benzylic position of o-QM skeleton (Fig. 8, 1aVS 1b). Subsequent oxygen anion attack to oxonium ion affords the desired optical tetracyclic isochroman from Si face, while the Re face of the oxonium ion is shielded by the N,N’-dioxide (Fig. 8, 1cVS 1d).
In summary, we designed and developed the first asymmetric HDA reaction of in-situ generated isochromene and o-QM based on insights from the biosynthetic pathway of polyketide oligomer natural products. This direct enantioselective cascade reaction was achieved through a Au(I)/Sc(III) bimetallic catalytic strategy, affording a series of chiral tetracyclic isochromans from readily available α-propargyl benzyl alcohols and 2-(hydroxylmethyl) phenols under mild conditions. Importantly, this work demonstrates the potential utility of biomimetic synthesis in the development of reaction and expanding the limitation of substrates comparing to biosynthesis expansion, which encourages us to explore biomimetic catalytic reactions in the future.
Methods
General experimental procedure of asymmetric cascade reaction
To a 10-mL test-tube were sequentially added JohnphosAu (0.010 mmol, 7.7 mg), Sc(OTf)3 (0.020 mmol, 9.8 mg), L-PiMe2t-Bu (0.022 mmol, 14.4 mg) and CH2Cl2 (2.0 mL). The mixture stirred for 15 min. α-Propargyl benzyl alcohol 3 (0.3 mmol) and substrate 2 (0.2 mmol) were added in turn to the solution at 6 °C. The reaction mixture was monitored by TLC. Upon completion, the residual was purified by silica gel flash chromatography (petroleum ether:ethyl acetate, 20:1) to afford the desired product 4. The racemic examples were prepared by the catalysis of Sc(OTf)3 in r.t.
Experimental procedure for synthesis of 6
Under Ar atmosphere, to a 10-mL test-tube were sequentially added 4d (0.4 mmol, 136.8 mg) (89% ee), CH2Cl2 (2.0 mL), Et3SiH (0.4 mmol, 46.4 mg) and BF3·Et2O (0.2 mL) in 0 °C. Upon completion (2 h) the residual was purified by silica gel flash chromatography (petroleum ether:ethyl acetate, 5:1) to afford the desired product 6.
Experimental procedure for synthesis of 7
Under Ar atmosphere, to a 10-mL test-tube were sequentially added 4d (0.2 mmol, 68.4 mg) (89% ee), CH2Cl2 (2.0 mL), Et3SiH (0.2 mmol, 23.2 mg) and TiCl4 (0.1 mL) in 0 °C. Upon completion (2 h) the residual was purified by silica gel flash chromatography (petroleum ether:ethyl acetate, 5:1) to afford the desired product 7.
Data availability
Crystallographic data have been deposited in the Cambridge Crystallographic Data. Center under accession number CCDC: 2036557. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via.
References
Sudek, S. et al. Identification of the putative bryostatin polyketide synthase Gene cluster from “Candidatus Endobugula sertula”, the uncultivated microbial symbiont of the marine bryozoan bugula neritina. J. Nat. Prod. 70, 67–74 (2007).
Hang, L., Liu, N. & Tang, Y. Coordinated and iterative enzyme catalysis in fungal polyketide biosynthesis. ACS Catal. 6, 5935–5945 (2016).
Nivina, A., Yuet, K. P., Hsu, J. & Khosla, C. evolution and diversity of assembly-line polyketide synthases. Chem. Rev. 119, 12524–12547 (2019).
Asai, T. et al. Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression. Org. Lett. 15, 3346–3349 (2013).
Asai, T., Yamamoto, T. & Oshima, Y. Aromatic polyketide production in cordyceps indigotica, an entomopathogenic fungus, Induced by exposure to a histone deacetylase inhibitor. Org. Lett. 14, 2006–2009 (2012).
Obata, T. et al. Gold-catalyzed domino synthesis of functionalized benzofurans and tetracyclic isochromans via formal carboalkoxylation. Org. Lett. 18, 4136–4139 (2016).
Amouri, H. & Le Bras, J. Taming reactive phenol tautomers and o-quinone methides with transition metals: a structure-reactivity relationship. Acc. Chem. Res. 35, 501–510 (2002).
Ferreira, S. B., da Silva, Fd. C., Pinto, A. C., Gonzaga, D. T. G. & Ferreira, V. F. Syntheses of chromenes and chromanes via o-quinone methide intermediates. J. Hetero Chem. 46, 1080–1097 (2009).
El-Sepelgy, O., Haseloff, S., Alamsetti, S. K. & Schneider, C. Brønsted acid catalyzed, conjugate addition of beta-dicarbonyls to in situ generated ortho-quinone methides enantioselective synthesis of 4-aryl-4H-chromenes. Angew. Chem. Int. Ed. 53, 7923–7927 (2014).
Hsiao, C. C., Liao, H. H. & Rueping, M. Enantio- and diastereoselective access to distant stereocenters embedded within tetrahydroxanthenes: utilizing ortho-quinone methides as reactive intermediates in asymmetric Brønsted acid catalysis. Angew. Chem. Int. Ed. 53, 13258–13263 (2014).
Saha, S. & Schneider, C. Directing group assisted nucleophilic substitution of propargylic alcohols via o-quinone methide intermediates: brønsted acid catalyzed, highly enantio- and diastereoselective synthesis of 7-alkynyl-12a-acetamido-substituted benzoxanthenes. Org. Lett. 17, 648–651 (2015).
Hsiao, C. C., Raja, S., Liao, H. H., Atodiresei, I. & Rueping, M. Ortho-quinone methides as reactive intermediates in asymmetric Brønsted acid catalyzed cycloadditions with unactivated alkenes by exclusive activation of the electrophile. Angew. Chem. Int. Ed. 54, 5762–5765 (2015).
Lai, Z., Wang, Z. & Sun, J. Organocatalytic asymmetric nucleophilic addition to o-quinone methides by alcohols. Org. Lett. 17, 6058–6061 (2015).
Wang, Z. & Sun, J. Recent advances in catalytic asymmetric reactions of o-quinone methides. Synthesis 47, 3629–3644 (2015).
Zhao, W., Wang, Z., Chu, B. & Sun, J. Enantioselective formation of all-carbon quaternary stereocenters from indoles and tertiary alcohols bearing a directing group. Angew. Chem. Int. Ed. 54, 1910–1913 (2015).
Guo, W. et al. Formal asymmetric catalytic thiolation with a bifunctional catalyst at a water-oil Interface: synthesis of benzyl thiols. Angew. Chem. Int. Ed. 54, 4522–4526 (2015).
Alamsetti, S. K., Spanka, M. & Schneider, C. Synergistic rhodium/phosphoric acid catalysis for the enantioselective addition of oxonium ylides to ortho-Qquinone methides. Angew. Chem. Int. Ed. 55, 2392–2396 (2016).
Jaworski, A. A. & Scheidt, K. A. Emerging roles of in situ generated quinone methides in metal-free catalysis. J. Org. Chem. 81, 10145–10153 (2016).
Wang, Z. & Sun, J. Enantioselective [4+2] cycloaddition of o-quinone methides and vinyl sulfides: indirect access to generally substituted chiral chromanes. Org. Lett. 19, 2334–2337 (2017).
Wang, Z., Wang, T., Yao, W. & Lu, Y. Phosphine-catalyzed enantioselective [4 + 2] annulation of o-quinone methides with allene ketones. Org. Lett. 19, 4126–4129 (2017).
Chen, P. et al. Enantioselective reactions of 2-sulfonylalkyl phenols with allenic esters: dynamic kinetic resolution and [4+2] cycloaddition involving ortho-quinone methide intermediates. Angew. Chem. Int. Ed. 56, 3689–3693 (2017).
Suneja, A. & Schneider, C. Phosphoric acid catalyzed [4+1]-cycloannulation reaction of ortho-quinone methides and diazoketones: catalytic, enantioselective access toward cis-2,3-dihydrobenzofurans. Org. Lett. 20, 7576–7580 (2018).
Sun, M. et al. Catalytic asymmetric (4+3) cyclizations of in situ generated ortho-quinone methides with 2-indolylmethanols. Angew. Chem. Int. Ed. 58, 8703–8708 (2019).
Liu, X., Wang, K., Guo, W., Liu, Y. & Li, C. An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface. Chem. Commun. 55, 2668–2671 (2019).
Suneja, A., Loui, H. J. & Schneider, C. Cooperative catalysis for the highly diastereo- and enantioselective [4+3]-cycloannulation of ortho-quinone methides and carbonyl ylides. Angew. Chem. Int. Ed. 59, 5536–5540 (2020).
Lin, X., Liu, Y. & Li, C. Allylsilane reagent-controlled divergent asymmetric catalytic reactions of 2-naphthoquinone-1-methide. Chem. Eur. J. 26, 14173–14180 (2020).
Asai, T. et al. Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides. Nat. Chem. 7, 737–743 (2015).
Yang, B. & Gao, S. Recent advances in the application of Diels-Alder reactions involving o-quinodimethanes, aza-o-quinone methides and o-quinone methides in natural product total synthesis. Chem. Soc. Rev. 47, 7926–7953 (2018).
Long, J., Hu, J., Shen, X., Ji, B. & Ding, K. Discovery of exceptionally efficient catalysts for solvent-free enantioselective hetero-Diels−Alder reaction. J. Am. Chem. Soc. 124, 10–11 (2002).
Du, H., Long, J., Hu, J., Li, X. & Ding, K. 3,3‘-Br2-BINOL-Zn complex: a highly efficient catalyst for the enantioselective hetero-Diels−Alder reaction. Org. Lett. 4, 4349–4352 (2002).
Du, H. & Ding, K. Enantioselective catalysis of hetero-Diels-Alder reaction and diethylzinc addition using a single catalyst. Org. Lett. 5, 1091–1093 (2003).
Bender, C. F., Yoshimoto, F. K., Paradise, C. L. & De Brabander, J. K. A concise synthesis of berkelic acid inspired by combining the natural products spicifernin and pulvilloric acid. J. Am. Chem. Soc. 131, 11350–11352 (2009).
Takao, K.-i et al. Total synthesis of (+)-Cytosporolide A via a biomimetic hetero-Diels–Alder reaction. J. Am. Chem. Soc. 137, 15971–15977 (2015).
Purgett, T. J., Dyer, M. W., Bickel, B., McNeely, J. & Porco, J. A. Gold(I)-mediated cycloisomerization/cycloaddition enables bioinspired syntheses of neonectrolides B-E and analogues. J. Am. Chem. Soc. 141, 15135–15144 (2019).
Zi, W. & Toste, F. D. Recent advances in enantioselective gold catalysis. Chem. Soc. Rev. 45, 4567–4589 (2016).
Wu, H., He, Y.-P. & Gong, L.-Z. Direct access to enantioenriched spiroacetals through asymmetric relay catalytic three-component reaction. Org. Lett. 15, 460–463 (2013).
Wang, X. et al. Synthesis of fused bicyclic aminals through sequential gold/Lewis acid catalysis. Org. Lett. 15, 2234–2237 (2013).
Kambale, D. A., Thorat, S. S., Pratapure, M. S., Gonnade, R. G. & Kontham, R. Lewis acid catalyzed cascade annulation of alkynols with α-ketoesters: a facile access to γ-spiroketal-γ-lactones. Chem. Comm. 53, 6641–6644 (2017).
Wang, C.-S. et al. Metal-catalyzed oxa-[4+2] cyclizations of quinone methides with alkynyl benzyl alcohols. J. Org. Chem. 83, 13861–13873 (2018).
Thorat, S. S., Kataria, P. & Kontham, R. Synthesis of furo[2,3-b]pyran-2-ones through Ag(I)- or Ag(I)-Au(I)-catalyzed cascade annulation of alkynols and α-ketoesters. Org. Lett. 20, 872–875 (2018).
Hu, B. et al. Asymmetric synthesis of fused bicyclic N,O-and O,O-acetals via cascade reaction by gold(I)/N,N’-dioxide-Nickel(II) bimetallic relay catalysis. Adv. Synth. Catal. 360, 2831–2835 (2018).
Zhang, S., Wei, F., Song, C., Jia, J. & Xu, Z. Recent advances of the combination of Au/acid catalysis. Chin. J. Chem. 32, 937–956 (2014).
Wang, X. et al. Synthesis of spiroaminals and spiroketals with bimetallic relay catalysis. Org. Lett. 16, 22–25 (2014).
Zhang, S., Xu, Z., Jia, J., Tung, C.-H. & Xu, Z. Synthesis of spiroaminals by bimetallic Au/Sc relay catalysis: TMS as a traceless controlling group. Chem. Comm. 50, 12084–12087 (2014).
Wang, B. et al. Gold/Lewis acid catalyzed cycloisomerization/diastereoselective [3 + 2] cycloaddition cascade: synthesis of diverse nitrogen-containing spiro heterocycles. Org. Lett. 18, 4614–4617 (2018).
Liang, M. et al. Synthesis of spiroketals by synergistic gold and scandium catalysis. Org. Lett. 19, 2526–2529 (2017).
Zhang, S. et al. Gold-catalyzed cycloisomerization/1,5-H migration/Diels–alder reaction cascade: synthesis of complex nitrogen-containing heterocycles. Org. Lett. 19, 1072–1075 (2017).
Qi, J., Teng, Q., Thirupathi, N., Tung, C.-H. & Xu, Z. Diastereoselective synthesis of Polysubstituted spirocyclopenta[c]furans by gold-catalyzed cascade reaction. Org. Lett. 21, 692–695 (2019).
Mao, W. et al. Gold-catalyzed domino reactions of alkynol and p-quinone methides: divergent synthesis of fused- and spiro-ketals. Org. Chem. Front. 7, 856–861 (2020).
Li, J. et al. Bimetallic gold(I)/chiral N,N’-dioxide Nickel(II) asymmetric relay catalysis: chemo- and enantioselective synthesis of spiroketals and spiroaminals. Angew. Chem. Int. Ed. 55, 6075–6078 (2016).
Gong, J., Wan, Q. & Kang, Q. Gold(I)/chiral Rh(III) Lewis acid relay catalysis enables asymmetric synthesis of spiroketals and spiroaminals. Adv. Syn. Catal. 360, 4031–4036 (2018).
Liu, X., Lin, L. & Feng, X. Chiral N,N’-dioxides: new ligands and organocatalysts for catalytic asymmetric reactions. Acc. Chem. Res. 44, 574–587 (2011).
Liu, X., Lin, L. & Feng, X. Chiral N,N’-dioxide ligands: synthesis, coordination chemistry and asymmetric catalysis. Org. Chem. Front. 1, 298–302 (2014).
Liu, X., Zheng, H., Xia, Y., Lin, L. & Feng, X. Asymmetric cycloaddition and cyclization reactions catalyzed by chiral N,N’-dioxide-metal complexes. Acc. Chem. Res. 50, 2621–2631 (2017).
Li, J. et al. Gold(I)/chiral N,N′-dioxide-Nickel(II) relay catalysis for asymmetric tandem intermolecular hydroalkoxylation/Claisen rearrangement. Angew. Chem. Int. Ed. 56, 885–888 (2017).
Ge, S. et al. Bimetallic catalytic asymmetric tandem reaction of β-alkynyl ketones to synthesize 6,6-spiroketals. Angew. Chem. Int. Ed. 58, 4017–4021 (2019).
Zheng, H. et al. Diversified 1,6-enynes cycloisomerization/Diels-Alder reactions via bimetallic relay asymmetric catalysis. Angew. Chem. Int. Ed. 58, 5327–5331 (2019).
Ge, S. et al. Bimetallic catalytic tandem reaction of acyclic enynones: enantioselective access to tetrahydrobenzofuran derivatives. Org. Lett. 22, 3551–3556 (2020).
Wang, Z., Liu, X. & Feng, X. Asymmetric catalysis enabled by chiral N,N’-Dioxide- Nickel(II) complexes. Aldrichimica ACTA 53, 3–10 (2020).
Wang, M. & Li, W. Feng ligand: privileged chiral ligand in asymmetric catalysis. Chin. J. Chem. 39, 96–984 (2021).
Hu, X., Tang, X., Zhang, X., Lin, L. & Feng, X. Catalytic asymmetric nakamura reaction by Gold(I)/chiral N,Nʹ-dioxide-indium(III) or Nickel(II) synergistic catalysis. Nat. Commun. 12, 3012–3021 (2021).
Singleton, D. A. & Thomas, A. A. High-precision simultaneous determination of multiple small kinetic isotope effects at natural abundance. J. Am. Chem. Soc. 117, 9357–9358 (1995).
Bartelson, K. J., Singh, R. P., Foxman, B. M. & Deng, L. Catalytic asymmetric 4+2 additions with aliphatic nitroalkenes. Chem. Sci. 2, 1940–1944 (2011).
Zhang, D., Lin, L., Yang, J., Liu, X. & Feng, X. Asymmetric synthesis of tetrahydroindolizines by bimetallic relay catalyzed cycloaddition of pyridinium ylides. Angew. Chem. Int. Ed. 57, 12323–12327 (2018).
Acknowledgements
We appreciate the National Natural Science Foundation of China (21871254, 21532006, 21472187) and DICP (DICP ZZBS201602).
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X. Lin. performed experiments and prepared the Supplementary Information and manuscript. X. Liu., K.W., and Q.L. participated some discussions and provided some suggestions. Y. L. and C. L. directed the project and helped with modifying the paper.
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Lin, X., Liu, X., Wang, K. et al. Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman. Nat Commun 12, 4958 (2021). https://doi.org/10.1038/s41467-021-25198-y
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DOI: https://doi.org/10.1038/s41467-021-25198-y
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