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Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2


Photoredox-mediated umpolung strategy provides an alternative pattern for functionalization of carbonyl compounds. However, general approaches towards carboxylation of carbonyl compounds with CO2 remain scarce. Herein, we report a strategy for visible-light photoredox-catalyzed umpolung carboxylation of diverse carbonyl compounds with CO2 by using Lewis acidic chlorosilanes as activating/protecting groups. This strategy is general and practical to generate valuable α-hydroxycarboxylic acids. It works well for challenging alkyl aryl ketones and aryl aldehydes, as well as for α-ketoamides and α-ketoesters, the latter two of which have never been successfully applied in umpolung carboxylations with CO2 (to the best of our knowledge). This reaction features high selectivity, broad substrate scope, good functional group tolerance, mild reaction conditions and facile derivations of products to bioactive compounds, including oxypheonium, mepenzolate bromide, benactyzine, and tiotropium. Moreover, the formation of carbon radicals and carbanions as well as the key role of chlorosilanes are supported by control experiments.


Carbonyl compounds, especially ketones and aldehydes, are important bulk chemicals in industry and they exist widely in natural products, pharmaceuticals, and materials. The electronic structure of the carbonyl group renders it sensitive to attack from nucleophiles at the carbon center. Different from the inherent reactivity, the umpolung strategy has been investigated extensively to achieve C–C and C–X bond formations with non-nucleophilic reaction partners1,2,3. Notably, significant attention has been paid to recent progress in visible-light-driven umpolung reactions of carbonyl compounds owing to their mild reaction conditions and green processes2,3. In addition to direct single electron transfer (SET) reduction of carbonyls4, the photocatalytic proton-coupled electron transfer (PCET)5 approach represents a powerful tool for SET reduction of unactivated carbonyls to generate ketyl radicals (Fig. 1a), which then could undergo diverse transformations, including ketyl-olefin/alkyne coupling6,7,8,9,10, ketyl-ketyl homocoupling (pinacol coupling)11, and other couplings12,13,14,15,16. Such electron-rich ketyl radical intermediates, however, rarely undergo a second photocatalytic SET reduction process to produce a carbanionic species17,18,19,20. Meanwhile, the introduction of protons can accelerate pinacol coupling side reactions20. We envisioned the photoredox-catalyzed umpolung functionalization of carbonyl groups by using the Lewis acidic chlorosilane as an activating/protecting groups (Fig. 1b).

Fig. 1: Strategies for umpolung functionalization of carbonyl compounds via photocatalysis.

a Previous strategy: proton-coupled electron transfer via photocatalysis. b Our design: chlorosilane-coupled electron transfer via photocatalysis. c This work: a general umpolung carboxylation of carbonyls via photocatalysis. FG functional groups, PC photocatalyst.

α-Hydroxycarboxylic acids are highly important motifs in pharmaceutical and polymer industries (Fig. 2)21,22,23,24,25,26,27,28,29. As traditional methods through cyanation and hydrolysis suffer from the use of toxic cyanide and harsh conditions, chemists have long searched for more sustainable synthetic routes30. Compared to cyanide and carbon monoxide, CO2 represents a better choice as a C1 source in carboxylation due to its abundance, nontoxicity, and recyclability31,32,33,34,35,36,37,38,39. Although significant progress has been achieved in recent decades to generate α-hydroxycarboxylic acids with CO218,19,20,40,41,42,43, most of these methods suffer from the utilization of stoichiometric amounts of metal reductants, low functional group tolerance, limited substrate scope, and/or competitive side reactions, especially the pinacol coupling and reduction, thus hampering industrial application. Therefore, a general and practical method is desirable. Inspired by recent visible-light-driven reductive carboxylations of different electrophiles with CO244,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59, we wondered whether we could develop a general and practical strategy to achieve efficient and selective carboxylation of carbonyls with CO2 via visible-light photoredox catalysis. Achieving such a goal requires addressing several challenges. First, it is highly challenging to avoid common side reactions, namely pinacol coupling11 and hydrogen atom transfer (HAT) of ketyl radicals60. Second, as the direct radical addition of ketyl radicals to CO2 is less favored61,62, a second SET reduction to generate a carbanion, which could attack electrophilic CO2, would be promising. However, the direct SET reduction of electron-rich ketyl radicals and/or ketyl radical anions is challenging. Third, it is very difficult to avoid other processes, including direct α-carboxylation63 and homo-aldol reaction64 of alkyl ketones, as well as the disproportionation65 of aldehydes (Cannizzaro reaction) under basic conditions. Here, we show a general and practical reductive carboxylation of carbonyl compounds, such as alkyl aryl ketones, diaryl ketones, α-ketoamides, α-ketoesters, and aryl aldehydes, with CO2 to give valuable α-hydroxycarboxylic acids (Fig. 1c).

Fig. 2: The significance of α-Hydroxycarboxylic acids.

Selected examples of bioactive molecules and natural products that containing α-Hydroxycarboxylic acids moiety.


With such challenges in mind, we were inspired by PCET5 and hypothesized whether we could use a Lewis acidic chlorosilane instead of a proton as an activating group to promote the visible light-driven SET reduction of a carbonyl group, which has never been reported yet. Moreover, the activating chlorosilane might act as a temporary protecting group to generate α-silyloxy carbon radicals, which would increase the steric hindrance of the radical intermediates and thus retard undesired pinacol coupling. Based on this hypothesis, we started the investigation of reductive carboxylation with 4-acetylbiphenyl 1a as a model substrate (Fig. 3). When we used Cs2CO3 as base, iPr2NEt as the electron donor and N,N-dimethylformamide (DMF) as solvent (entry 1), the desired product 2a was obtained in 36% yield along with pinacol 2a in 54% yield. We were pleased to find that the use of triethylsilylchloride (TESCl) as an additive significantly improved the selectivity to afford 2a in 52% yield and 2a in 29% yield (entry 2). After systematic screening of different bases, solvents, chlorosilanes, and other Lewis acids (entries 3–9. Please see Supplementary Information (SI) for more details), we found that the combination of trimethylsilylchloride (TMSCl) as additive, KOtBu as base, and N,N-dimethylacetamide (DMA) as solvent was the best choice to give 2a in 80% isolated yield (entry 7). Control experiments indicated that all of the components (PC, base, TMSCl, iPr2NEt, light, and CO2) played crucial roles in this successful transformation (entries 10–15).

Fig. 3: Reaction optimization.

aReaction conditions: 1a (0.2 mmol), Ir(ppy)2(dtbbpy)PF6 (1.0 mol %), base (2.0 equiv), iPr2NEt (2.0 equiv), additive (1.0 equiv) in solvent (2.0 mL) at room temperature (RT) in CO2 atmosphere under irradiation with 30 W blue LED for 12 h. The corresponding reductive product alcohol, 1-([1,1′-biphenyl]-4-yl)ethan-1-ol 2a″, was observed as a minor byproduct in generally lower than 10% yield. bYields were determined by UPLC analysis with 1,1′-biphenyl as internal standard. The isolated yields are given in parentheses. cChlorosilane (1.3 equiv). dWithout light. eWithout Ir(ppy)2(dtbbpy)PF6. fWithout iPr2NEt. gUnder N2 atmosphere. n.d. not detected, LED light-emitting diode, DMSO dimethyl sulfoxide, dtbbpy 4,4′-di-tert-butyl-2,2′-bipyridine, ppy 2-phenylpyridine, TMS trimethylsilyl.

With appropriate reaction conditions in hand, we began to explore the substrate scope of alkyl aryl ketones, which are prone to undergo α-carboxylation63 and homo-aldol reaction64 in the presence of base. To our delight, as shown in Fig. 4, ketones bearing different alkyl groups, such as methyl (1a, 1f, 1g, 1h, 1k, 1l), ethyl (1b), n-butyl (1c), isopropyl (1d), tert-butyl (1e), cyclohexyl (1i), and benzyl (1j), all underwent the umpolung carboxylation selectively. Although increased steric hindrance on the alkyl groups induced lower reactivity, the desired products (2d, 2e, 2i) were obtained in good yields when 2,4,6-tris(diphenylamino)-3,5-difluorobenzonitrile (3DPA2FBN) was used as the photocatalyst. Notably, the umpolung carboxylation of the challenging substrate 1i with CO2 to give 2i, which is a key motif in oxybutynin (Fig. 2), had not been realized previously21. In addition to substrate 1h, which is activated with an electron-withdrawing group (EWG), the effective conversion of substrates 1k and 1l bearing higher reduction potential (e.g., 1k (E1/2red = −2.1 V vs SCE)) could be achieved by using stronger reductive photosensitizer (3DPA2FBN, E1/2red = −1.92 V vs SCE)66, especially in the presence of TMSCl as carbonyl activating reagent. Moreover, esters (1h), methoxy groups (1l), naphthalene (1f), and thiophene (1g) moieties were tolerated under the reaction conditions. However, the dialkyl ketones and aldehydes, such as 4-phenylbutan-2-one and 3-phenylpropanal, were performed in standard condition, no desirable products were detected so far. It is presumably due to the higher reduction potential of the dialkyl ketones and alkyl aldehydes.

Fig. 4: Substrate scope of alkyl aryl ketones.

The standard conditions were used, as shown in Fig. 3, entry 7. Isolated yields of corresponding carboxylic acids 2 are shown. aUsing 3DPA2FBN (2.0 mol %) instead of Ir(ppy)2(dtbbpy)PF6. bKOtBu (2.5 equiv), DMA (4 mL).

Considering the importance of α-hydroxycarboxylic acids bearing two aryl groups, we further applied our catalytic system to the carboxylation of diaryl ketones (Fig. 5). Due to the higher reactivity and fewer side reactions, these substrates could undergo reductive carboxylation smoothly under milder reaction conditions. A variety of functional groups, such as trifluoromethyl (3e), fluoro (3f, 3l, 3o), chloro (3g, 3m), and methoxyl (3d), were tolerated at the para position of non-symmetric or symmetric diaryl ketones. Moreover, benzophenones bearing meta- (3h, 3i) or ortho-substitutions (3j, 3k) could afford the corresponding products in moderate to high yields (56–90%). Notably, the carboxylation of the benzylic C–H bond in 3k was not observed through HAT process by ketyl radical67. In addition to benzophenones, this method could be expanded to xanthone 3p, 2-benzoylthiophene 3q and di(thiophen-2-yl)methanone 3r.

Fig. 5: Substrate scope of diaryl ketones.

Reaction condition: ketones (0.2 mmol), Ir-catalyst (0.001 mmol), Cs2CO3 (0.4 mmol), iPr2NEt (0.3 mmol), DMF (2 mL), isolated yields of corresponding carboxylic acids, or methyl esters 4 are shown. aiPr2NEt (1.0 equiv).

As α-hydroxymalonic acid (tartronic acid) derivatives are important motifs in a range of natural products, the development of methods to synthesize them is imperative. The construction of such motifs via the umpolung carboxylation of α-ketoesters with CO2 has not been reported. Therefore, we further tried to apply this strategy in generation of α-hydroxymalonic acid derivatives. To our delight, this catalytic system worked well for selective umpolung carboxylation of α-ketoesters (Fig. 6). The challenging sterically hindered tert-butyl-substituted α-ketoester 5a showed good reactivity under standard reaction conditions to give the desired product 6a in 75% yield. Moreover, α-ketoesters bearing secondary (5b) and primary alkyl groups (5c5e) also were suitable substrates to afford the desired products in moderate to good yields. Notably, an α-hydroxymalonic acid derivative containing a cholesterol moiety (6f) was selectively obtained albeit in a diminished yield, demonstrating potential application of this strategy for late-stage diversification under mild conditions.

Fig. 6: Substrate scope of α-ketoesters and α-ketoamides.

The standard conditions were used, as shown in Fig. 3, entry 7. Isolated yields of corresponding carboxylic acids or methyl esters 6 are shown. aIsolated yield of corresponding benzoate ester upon work up with BzCl. Bz benzoyl.

Based on the success of α-ketoesters, we further tested the umpolung carboxylation of α-ketoamides with CO2, a process which has never been reported. Indeed, N-alkyl-N-aryl amides (5g5j) and N,N-dialkyl amide (5k) also reacted under the standard reaction conditions to afford the corresponding α-hydroxyamides in moderate yields. The steric hindrance of the alkyl group did not significantly affect the reaction, as demonstrated by the comparable yields for the carboxylations of N-alkyl-N-aryl amides (5g5j). However, amides containing an NH bond were not suitable substrates at this stage, which might because of the increased electron density of the carbonyl and/or the competitive quenching of deprotonated form of secondary amide with respect to iPr2NEt.

After demonstrating the viability of different kinds of ketones, we turned our attention to more challenging aryl aldehydes. Although umpolung carboxylations of aryl aldehydes with CO2 are rare43,68,69, α-hydroxycarboxylic acids synthesis typically suffer from low yields, low selectivity, and limited scope. When aryl aldehydes were applied as substrates to the standard reaction conditions, we observed a complicated mixture of products due to intense side reactions, including pinacol coupling and disproportionation, which might arise from the lower steric hindrance of aldehydes and the strong base. In order to prevent such side reactions, we further tested several bulky chlorosilanes and weak bases. After systematic screening, we were pleased to find a suitable option using potassium pivalate (KOPiv) as base and Ph3SiCl as additive (Fig. 7). Under these modified reaction conditions, umpolung carboxylation of 7a took place smoothly to afford, after esterification, the desired product 8a in 60% yield along with 33% of pinacol 8a. In contrast, 8a could only be obtained in 8% yield along with 63% of 8a in the absence of Ph3SiCl, which indicates the significance of Ph3SiCl to the carboxylation of aryl aldehydes. Several aryl aldehydes bearing different substituents, including thiol ether (7c) and thiophene (7d), reacted to give the desired α-hydroxycarboxylic esters in 30 min with moderate to good yields. Moreover, fused aryl aldehydes, such as 2-naphthaldehyde (7e) and phenanthrene-9-carboxaldehyde (7f), also reacted well.

Fig. 7: Substrate scope of aryl aldehydes.

Isolated yields of corresponding methyl esters are shown.

To gain more mechanistic insight into this transformation, we conducted several control experiments. As silyl enol ether 1A can be prepared easily from ketone 1a and TMSCl in the presence of base, we wondered whether it might act as the reaction intermediate. However, we failed to detect 1A at different stages of the standard reaction of 1a. To further confirm the assumption, we synthesized 1A and then applied it as the starting material for the carboxylation in the absence of TMSCl (Fig. 8a). We found that a lower yield of the desired product 2a-Me was generated along with the dimethyl 2-hydroxy-2-phenylsuccinate 9, which was never detected in the standard reaction of 1a, as a major byproduct. We hypothesized that the formation of 9 might involve the successive single electron transfer (SSET) reduction and carboxylation processes of the silyl enol ether 1A with CO270. Moreover, we observed the full decomposition of 1A under a N2 atmosphere to give 1a in 53% yield, indicating that the formation of 2a from 1A and CO2 might proceed with 1a as the real reactant. Meanwhile, we observed that the reduction potential of 1A was slightly higher than 1a (see below). Therefore, we excluded the possibility that silyl enol ether 1A is the key intermediate in the observed umpolung carboxylation. Moreover, alcohol 2a″ and TMS-protected 2a″ were treated with standard conditions, 2a was not observed, 2a″ and some dehydroxylative byproducts were detected, which rule out the direct C–H carboxylation pathway (please see the SI for details).

Fig. 8: Control experiments.

Isolated yields are shown. a Investigation of the possibility with sily enol ether 1A as intermediate. b Investigation of the effect of radical scavenger in the reaction. c Investigation of the effect of D2O in the reaction. aKOtBu (1.0 equiv) was used.

To further explore other intermediates in the reaction, we added a radical scavenger, 2,2,6,6-tetramethylpiperidinooxy (TEMPO), to the reaction of 1a under the standard conditions (Fig. 8b). In the presence of TEMPO, the reaction was completely suppressed, indicating that radicals might be involved in this reaction. Furthermore, we tested the effect of D2O on the carboxylation reaction. The generation of 2a″ from 1a was inhibited by the addition of D2O, thus precluding the determination of deuterium incorporation (please see the SI for details). The reaction of 3b in the presence of different amounts of D2O as additive, however, did provide alcohol 4b″ in up to 83% yield and 70% deuterium incorporation (Fig. 8c), suggesting that the benzylic carbanion is a possible intermediate.

To demonstrate that the activation of carbonyl groups by a Lewis acidic chlorosilane is a critical part of the reaction, we performed Stern–Volmer luminescence studies and electrochemistry investigations (please see the SI for details). The luminescence of Ir(ppy)2(dtbbpy)PF6 at λmax = 570 nm was readily quenched by iPr2NEt with a slope of 266.4 (Fig. 9a), which is much more significant than ketone 1a (−2.3) and TMSCl (51.2). These results suggest that the reaction proceeds with reductive quenching to give reduced IrII-catalyst (E1/2Red[IrIII/IrII] = −1.51 V vs SCE)71. Moreover, the cyclic voltammetry (CV) test (Fig. 9b) indicated that the presence of TMSCl promoted reduction of the carbonyl by lowering the reductive potential. Thus, we believe that the SET reduction of the TMSCl-activated ketone 1a is favored to give the corresponding α-silyloxyl benzyl radical72,73, which might be further reduced by the IrII-catalyst to generate a benzylic carbon anion. The following nucleophilic attack to CO2 would give the corresponding products (Fig. 9c).

Fig. 9: Mechanistic experiments and proposed mechanism.

a Stern-Volmer experiment. b Cyclic voltammetry (CV) tests. c Proposed mechanism.

In order to test other alternative pathways, such as coupling between benzyl radicals and a CO2 radical anion, we further detected the formation of formate from CO2. Although a turnover number (TON) of 43 for the generation of formate was observed in the absence of ketones, the reduction of CO2 was significantly depressed under the standard reaction of 1a (please see the SI for details). Meanwhile, the standard reduction potential of CO2 in dry DMF is −2.21 V vs SCE74. The reduction potentials of 1a, 1k, and 7a in DMF are −1.81 V vs SCE, −2.1 V vs SCE, and −1.76 V vs SCE (please see the SI for details). Moreover, the reduction potential of α-ketoesters (for methyl 3-methyl-2-oxobutanoate, E1/2red = −1.75 V vs SCE75) is also lower than CO2. These results indicated that the selective reduction of ketones over CO2.

With this methodology in hand, we further demonstrated its utility by testing the gram-scale reaction and the synthesis of valuable intermediates and bioactive compounds (Fig. 10). First of all, we were delighted to find that the gram-scale reaction of 3a (6.0 mmol) proceeded well with comparable yield and efficiency (Fig. 10a). Second, the product 2i could be reduced by LiAlH4 to give diol 10, which underwent cyclization to generate 1,3-dioxolane-2-thione 11 in a good yield (Fig. 10b)76. The esterification of 2i and the following fluorination of the C–O bond generated α-fluorocarboxylic ester 1277. Importantly, 2i could be transformed easily to bioactive oxypheonium 14. In addition, the cyclization of 8a with isocyanate could give oxazolidine-2,4-dione 1578. Moreover, as shown in Fig. 1, the product 4a could be readily converted into valuable anticholinergic drugs trospium chloride (Sanctura)24,27, mepenzolate bromide (Cantil)23, and benactyzine29. The α-hydroxycarboxylic acid 4r is also a synthetic precursor for the drugs tiotropium bromide (Spiriva) and aclidinium bromide (Tudorza)28.

Fig. 10: Synthetic applications.

a Gram-scale reaction. b Diverse functionalizations of products. (a) LiAlH4, THF, reflux. (b) TCDI, DCM, RT. (c) TMSCHN2, MeOH/Et2O; (d) Deoxofluor, DCM, RT, N2. (e) diethylamine, Na2CO3, DCE. (f) MeI, CH3CN, 65 °C. (g) p-Me-C6H4NCO, DMAP, THF, RT − 50 °C. TCDI = 1,1′-Thiocarbonyldiimidazole. DCM dichloromethane, Deoxofluor Bis(2-methoxyethyl)aminosulfur trifluoride, DMAP N,N-dimethylpyridin-4-amine, THF tetrahydrofuran.


In this work, we developed a strategy for the visible-light photoredox-catalyzed umpolung carboxylation of carbonyl groups with CO2 by using Lewis acidic chlorosilanes as activating/protecting groups. This strategy is general and practical for the carboxylation of diverse carbonyl compounds, including alkyl aryl ketones, diaryl ketones, α-ketoamides, α-ketoesters, and aryl aldehydes, to give valuable α-hydroxycarboxylic acids. The utility of this method is highlighted by facile generation of key intermediates to produce many drugs and natural products, including oxypheonium, mepenzolate bromide, benactyzine, and tiotropium. Moreover, this transformation features low catalyst loading, high selectivity, broad substrate scope, good functional group tolerance, mild reaction conditions (room temperature, 1 atm), and facile gram-scale reaction. The control experiments demonstrated the important role of chlorosilanes to promote the reaction and excluded the possibility of silyl enol ethers serving as key intermediates. Finally, carbon radicals and carbanions might be involved in this transformation.


Synthesis of 2a2l and 6a6k

The oven-dried Schlenk tube (10 mL) containing a stirring bar was charged with ketone (0.2 mmol), Ir(ppy)2(dtbbpy)PF6 (1.9 mg, 1 mol %), or 3DPA2FBN (2.6 mg, 0.004 mmol), then added tBuOK (44.9 or 60.9 mg, 0.4 or 0.5 mmol) in glovebox. The tube was taken out, evacuated, and back-filled with CO2 for three times. Subsequently, iPr2NEt (66 μL, 0.4 mmol), TMSCl (34 μL, 0.26 mmol), and DMA (2 or 4 mL) were added via syringe under CO2 atmosphere. Once added, the Schlenk tube was sealed at atmospheric pressure of CO2 (1 atm). The reaction was stirred in water bath and irradiated with a 30 W blue LED lamp (3 cm away, with cooling fan to keep the reaction temperature at 25–30 °C) for 12 h. After completion, 0.5 mL nBu4NF (1.0 N in THF) was carefully added to quench the reaction, the mixture was allowed to stir for 30 min at room temperature. Then, Work-up 1: the mixture was quenched with HCl (2 N), extracted with EtOAc, the combined organic phases were concentrated in vacuo. The residue was purified by silica gel flash chromatography (0.1% AcOH in petroleum ether/EtOAc) to give the corresponding α-hydroxycarboxylic acids as products. Or Work-up 2: MeI (37 μL, 3.0 equiv) was added via syringe. The resulting mixture was further stirred for 3 h at 60 °C. After cooling to room temperature, the mixture was quenched with HCl (2 N), extracted with EtOAc, the combined organic phases were concentrated in vacuo. The residue was purified by silica gel flash column chromatography (petroleum ether/EtOAc 100/1-50/1) to give the pure desired methyl α-hydroxycarboxylates.

Synthesis of 4a4r

The oven-dried Schlenk tube (10 mL) containing a stirring bar was charged with ketone (0.2 mmol), Ir(ppy)2(dtbbpy)PF6 (1.0 mg, 0.001 mmol, 0.5 mol %), then added Cs2CO3 (130.0 mg, 0.4 mmol) in glovebox. The tube was taken out, evacuated, and back-filled with CO2 for three times. Subsequently, iPr2NEt (33 or 50 μL, 0.2 or 0.3 mmol), DMF (2 mL) was added via syringe under CO2 atmosphere. Once added, the Schlenk tube was sealed at atmospheric pressure of CO2 (1 atm.). Then the work-up procedures were the same as above mentioned.

Synthesis of 8a8f

The oven-dried Schlenk tube (25 mL) containing a stirring bar was charged with aldehyde (0.2 mmol), Ir(ppy)2(dtbbpy)PF6 (1.9 mg, 0.002 mmol, 1 mol %), Ph3SiCl (76.7 mg, 0.26 mmol), and PivOK (84.1 mg, 0.6 mmol) in glovebox. The tube was taken out, evacuated, and back-filled with CO2 for three times. Subsequently, iPr2NEt (66 μL, 0.4 mmol) and DMA (6 mL) were added via syringe under CO2 atmosphere. Once added, the Schlenk tube was sealed at atmospheric pressure of CO2 (1 atm.). After completion, 0.5 mL nBu4NF (1.0 N in THF) was carefully added to quench the reaction, the mixture was quenched with HCl (2 N), extracted with EtOAc, the combined organic phases were concentrated in vacuo. The crude residue was dissolved in 4 mL MeOH/Et2O (1/3), TMSCHN2 (0.3 mL, 0.6 mmol, 2 M in hexanes) was added drop wisely at 0 °C. Upon completion. After removal of the solvent, the crude reaction mixture was purified on silica gel (petroleum ether and ethyl acetate) to afford the desired methyl α-hydroxycarboxylates.

Data availability

The authors declare that the data supporting the findings of this study are available within the article and its Supplementary Information files. Extra data are available from the author upon request.


  1. 1.

    Seebach, D. Methods of reactivity umpolung. Angew. Chem. Int. Ed. Engl. 18, 239–258 (1979).

    Article  Google Scholar 

  2. 2.

    Lee, K. N. & Ngai, M.-Y. Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives. Chem. Commun. 53, 13093–13112 (2017).

    CAS  Article  Google Scholar 

  3. 3.

    Xia, Q., Dong, J., Song, H. & Wang, Q. Visible-light photocatalysis of the ketyl radical coupling reaction. Chem. Eur. J. 25, 2949–2961 (2019).

    CAS  PubMed  Google Scholar 

  4. 4.

    Szostak, M., Fazakerley, N. J., Parmar, D. & Procter, D. J. Cross-coupling reactions using samarium(II) iodide. Chem. Rev. 114, 5959–6039 (2014).

    CAS  PubMed  Article  Google Scholar 

  5. 5.

    Gentry, E. C. & Knowles, R. R. Synthetic applications of proton-coupled electron transfer. Acc. Chem. Res. 49, 1546–1556 (2016).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  6. 6.

    Tarantino, K. T., Liu, P. & Knowles, R. R. Catalytic ketyl-olefin cyclizations enabled by proton-coupled electron transfer. J. Am. Chem. Soc. 135, 10022–10025 (2013).

    CAS  PubMed  Article  Google Scholar 

  7. 7.

    Qi, L. & Chen, Y. Polarity-reversed allylations of aldehydes, ketones, and imines enabled by Hantzsch ester in photoredox catalysis. Angew. Chem. Int. Ed. 55, 13312–13315 (2016).

    CAS  Article  Google Scholar 

  8. 8.

    Fava, E., Nakajima, M., Nguyen, A. L. P. & Rueping, M. Photoredox-catalyzed ketyl–olefin coupling for the synthesis of substituted chromanols. J. Org. Chem. 81, 6959–6964 (2016).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  9. 9.

    Lee, K. N., Lei, Z. & Ngai, M.-Y. β-Selective reductive coupling of alkenylpyridines with aldehydes and imines via synergistic lewis acid/photoredox catalysis. J. Am. Chem. Soc. 139, 5003–5006 (2017).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  10. 10.

    Wang, Z.-S. et al. Ynamide smiles rearrangement triggered by visible-light-mediated regioselective ketyl–ynamide coupling: rapid access to functionalized indoles and isoquinolines. J. Am. Chem. Soc. 142, 3636–3644 (2020).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  11. 11.

    Nakajima, M., Fava, E., Loescher, S., Jiang, Z. & Rueping, M. Photoredox-catalyzed reductive coupling of aldehydes. Ketones, Imines Visible Light. Angew. Chem. Int. Ed. 54, 8828–8832 (2015).

    CAS  Article  Google Scholar 

  12. 12.

    Rono, L. J., Yayla, H. G., Wang, D. Y., Armstrong, M. F. & Knowles, R. R. Enantioselective photoredox catalysis enabled by proton-coupled electron transfer: development of an asymmetric aza-pinacol cyclization. J. Am. Chem. Soc. 135, 17735–17738 (2013).

    CAS  PubMed  Article  Google Scholar 

  13. 13.

    Fava, E., Millet, A., Nakajima, M., Loescher, S. & Rueping, M. Reductive umpolung of carbonyl derivatives with visible-light photoredox catalysis: direct access to vicinal diamines and amino alcohols via α-amino radicals and ketyl radicals. Angew. Chem. Int. Ed. 55, 6776–6779 (2016).

    CAS  Article  Google Scholar 

  14. 14.

    Li, W., Duan, Y., Zhang, M., Cheng, J. & Zhu, C. A photoredox catalyzed radical–radical coupling reaction: facile access to multi-substituted nitrogen heterocycles. Chem. Commun. 52, 7596–7599 (2016).

    CAS  Article  Google Scholar 

  15. 15.

    Chen, M., Zhao, X., Yang, C. & Xia, W. Visible-light-triggered directly reductive arylation of carbonyl/iminyl derivatives through photocatalytic PCET. Org. Lett. 19, 3807–3810 (2017).

    CAS  PubMed  Article  Google Scholar 

  16. 16.

    Xia, Q. et al. N-Arylamines coupled with aldehydes, ketones, and imines by means of photocatalytic proton-coupled electron transfer. Chem. Eur. J. 24, 9269–9273 (2018).

    CAS  PubMed  Article  Google Scholar 

  17. 17.

    Lin, L. et al. Organocatalytic enantioselective protonation for photoreduction of activated ketones and ketimines induced by visible light. Angew. Chem. Int. Ed. 56, 13842–13846 (2017).

    CAS  Article  Google Scholar 

  18. 18.

    Masashi, K., Hirofumi, A., Yuji, W. & Shozo, Y. Visible-light induced photofixation of CO2 into benzophenone catalyzed by colloidal CdS microcrystallites. Chem. Lett. 21, 2113–2114 (1992).

    Article  Google Scholar 

  19. 19.

    Tomoyuki, O., Kunizo, H., Shinjiro, M., Yuji, W. & Shozo, Y. Visible-light induced photocatalytic fixation of CO2 into benzophenone using poly(p-phenylene) as a photocatalyst. Chem. Lett. 22, 983–984 (1993).

    Article  Google Scholar 

  20. 20.

    Scialdone, O. et al. Electrocarboxylation of aromatic ketones: influence of operative parameters on the competition between ketyl and ring carboxylation. J. Electroanal. Chem. 609, 8–16 (2007).

    CAS  Article  Google Scholar 

  21. 21.

    Thompson, I. M. & Lauvetz, R. Oxybutynin in bladder spasm, neurogenic bladder, and enuresis. Urology 8, 452–454 (1976).

    CAS  PubMed  Article  Google Scholar 

  22. 22.

    Middleton, B., Cacciaguerra, F. & White, D. Cyclandelate: an inhibitor of cholesterol esterification. Drugs 33, 75–79 (1987).

    CAS  PubMed  Article  Google Scholar 

  23. 23.

    Yamashita, Y. et al. Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities. Bioorg. Med. Chem. 22, 3488–3497 (2014).

    CAS  PubMed  Article  Google Scholar 

  24. 24.

    Rovner, E. S. Trospium chloride in the management of overactive bladder. Drugs 64, 2433–2446 (2004).

    CAS  PubMed  Article  Google Scholar 

  25. 25.

    Jang, J.-H., Kanoh, K., Adachi, K. & Shizuri, Y. Awajanomycin, a cytotoxic γ-lactone-δ-lactam metabolite from marine-derived Acremonium sp. AWA16-1. J. Nat. Prod. 69, 1358–1360 (2006).

    CAS  PubMed  Article  Google Scholar 

  26. 26.

    Reddy, D. S., Shibata, N., Nagai, J., Nakamura, S. & Toru, T. A dynamic kinetic asymmetric transformation in the α-hydroxylation of racemic malonates and its application to biologically active. Molecules. Angew. Chem. Int. Ed. 48, 803–806 (2009).

    Article  CAS  Google Scholar 

  27. 27.

    Krebs, A., Schäfer, B. & Kochner, A. Method for producing azoniaspironortropine esters and nortropan-3-one compounds. US2010/48903, A1 (2010).

  28. 28.

    Xiang, Z., Liu, J., Sun, H. & Wen, X. Discovery of novel potent muscarinic M3 receptor antagonists with proper plasma stability by structural recombination of marketed M3 antagonists. ChemMedChem 12, 1173–1182 (2017).

    CAS  PubMed  Article  Google Scholar 

  29. 29.

    da Silva, A. F., Afonso, M. A. S., Cormanich, R. A. & Jurberg, I. D. Room temperature coupling of aryldiazoacetates with boronic acids enhanced by blue light irradiation. Chem. Eur. J. 26, 5648–5653 (2020).

    PubMed  Article  CAS  Google Scholar 

  30. 30.

    Coppola, G. M. & Schuster, H. F. a-Hydroxy Acids in Enantioselective Syntheses (Wiley-VCH, 1997).

  31. 31.

    Liu, Q., Wu, L., Jackstell, R. & Beller, M. Using carbon dioxide as a building block in organic synthesis. Nat. Commun. 6, 5933 (2015).

    ADS  PubMed  Article  CAS  Google Scholar 

  32. 32.

    Luo, J. & Larrosa, I. C−H carboxylation of aromatic compounds through CO2 fixation. ChemSusChem 10, 3317–3332 (2017).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  33. 33.

    Tortajada, A., Juliá-Hernández, F., Börjesson, M., Moragas, T. & Martin, R. Transition-metal-catalyzed carboxylation reactions with carbon dioxide. Angew. Chem. Int. Ed. 57, 15948–15982 (2018).

    CAS  Article  Google Scholar 

  34. 34.

    Grignard, B., Gennen, S., Jérôme, C., Kleij, A. W. & Detrembleur, C. Advances in the use of CO2 as a renewable feedstock for the synthesis of polymers. Chem. Soc. Rev. 48, 4466–4514 (2019).

    CAS  PubMed  Article  Google Scholar 

  35. 35.

    Zhang, L., Li, Z., Takimoto, M. & Hou, Z. Carboxylation reactions with carbon dioxide using N-heterocyclic carbene-copper catalysts. Chem. Rec. 20, 494–512 (2020).

    PubMed  Article  CAS  Google Scholar 

  36. 36.

    Song, L. et al. CO2 = CO + [O]: recent advances in carbonylation of C–H bonds with CO2. Chem. Commun. 56, 8355–8367 (2020).

    Article  Google Scholar 

  37. 37.

    Cao, Y., He, X., Wang, N., Li, H.-R. & He, L.-N. Photochemical and electrochemical carbon dioxide utilization with organic compounds. Chin. J. Chem. 36, 644–659 (2018).

    CAS  Article  Google Scholar 

  38. 38.

    Huang, K., Sun, C.-L. & Shi, Z.-J. Transition-metal-catalyzed C–C bond formation through the fixation of carbon dioxide. Chem. Soc. Rev. 40, 2435–2452 (2011).

    CAS  PubMed  Article  Google Scholar 

  39. 39.

    Hong, J., Li, M., Zhang, J., Sun, B. & Mo, F. C−H bond carboxylation with carbon dioxide. ChemSusChem 12, 6–39 (2019).

    ADS  CAS  PubMed  Article  Google Scholar 

  40. 40.

    Liu, R. et al. Silicon nanowires as photoelectrodes for carbon dioxide fixation. Angew. Chem. Int. Ed. 51, 6709–6712 (2012).

    CAS  Article  Google Scholar 

  41. 41.

    Wang, H., Xu, X.-M., Lan, Y.-C., Wang, H.-M. & Lu, J.-X. Electrocarboxylation of haloacetophenones at silver electrode. Tetrahedron 70, 1140–1143 (2014).

    CAS  Article  Google Scholar 

  42. 42.

    Senboku, H., Sakai, K., Fukui, A., Sato, Y. & Yamauchi, Y. Efficient synthesis of mandel acetates by electrochemical carboxylation of benzal diacetates. ChemElectroChem 6, 4158–4164 (2019).

    CAS  Article  Google Scholar 

  43. 43.

    Masada, K., Kusumoto, S. & Nozaki, K. Reductive coupling of carbon dioxide and an aldehyde mediated by a copper(I) complex toward the synthesis of α-hydroxycarboxylic acids. Org. Lett. 22, 4922–4926 (2020).

    CAS  PubMed  Article  Google Scholar 

  44. 44.

    Yeung, C. S. Photoredox catalysis as a strategy for CO2 incorporation: direct access to carboxylic acids from a renewable feedstock. Angew. Chem. Int. Ed. 58, 5492–5502 (2019).

    CAS  Article  Google Scholar 

  45. 45.

    Ye, J.-H., Ju, T., Huang, H., Liao, L.-L. & Yu, D.-G. Radical carboxylative cyclizations and carboxylations with CO2. Acc. Chem. Res. 54, 2518–2531 (2021).

    CAS  PubMed  Article  Google Scholar 

  46. 46.

    He, X., Qiu, L.-Q., Wang, W.-J., Chen, K.-H. & He, L.-N. Photocarboxylation with CO2: an appealing and sustainable strategy for CO2 fixation. Green. Chem. 22, 7301–7320 (2020).

    CAS  Article  Google Scholar 

  47. 47.

    Pradhan, S., Roy, S., Sahoo, B. & Chatterjee, I. Utilization of CO2 feedstock for organic synthesis by visible‐light photoredox catalysis. I. Chem. Eur. J. 27, 2254–2269 (2021).

    CAS  PubMed  Article  Google Scholar 

  48. 48.

    Cai, B., Cheo, H. W., Liu, T. & Wu, J. Light-promoted organic transformations utilizing carbon-based gas molecules as feedstocks. Angew. Chem. Int. Ed. (2021).

  49. 49.

    Murata, K., Numasawa, N., Shimomaki, K., Takaya, J. & Iwasawa, N. Construction of a visible light-driven hydrocarboxylation cycle of alkenes by the combined use of Rh(I) and photoredox catalysts. Chem. Commun. 53, 3098–3101 (2017).

    CAS  Article  Google Scholar 

  50. 50.

    Shimomaki, K., Murata, K., Martin, R. & Iwasawa, N. Visible-light-driven carboxylation of aryl halides by the combined use of palladium and photoredox catalysts. J. Am. Chem. Soc. 139, 9467–9470 (2017).

    CAS  PubMed  Article  Google Scholar 

  51. 51.

    Meng, Q.-Y., Wang, S. & König, B. Carboxylation of aromatic and aliphatic bromides and triflates with CO2 by dual visible-light–nickel catalysis. Angew. Chem. Int. Ed. 56, 13426–13430 (2017).

    CAS  Article  Google Scholar 

  52. 52.

    Meng, Q.-Y., Wang, S., Huff, G. S. & König, B. Ligand-controlled regioselective hydrocarboxylation of styrenes with CO2 by combining visible light and nickel catalysis. J. Am. Chem. Soc. 140, 3198–3201 (2018).

    CAS  PubMed  Article  Google Scholar 

  53. 53.

    Hou, J. et al. Visible-light-driven alkyne hydro-/carbocarboxylation using CO2 via iridium/cobalt dual catalysis for divergent heterocycle synthesis. J. Am. Chem. Soc. 140, 5257–5263 (2018).

    CAS  PubMed  Article  Google Scholar 

  54. 54.

    Ju, T. et al. Selective and catalytic hydrocarboxylation of enamides and imines with CO2 to generate α,α-disubstituted α-amino acids. Angew. Chem. Int. Ed. 57, 13897–13901 (2018).

    CAS  Article  Google Scholar 

  55. 55.

    Fan, X., Gong, X., Ma, M., Wang, R. & Walsh, P. J. Visible light-promoted CO2 fixation with imines to synthesize diaryl α-amino acids. Nat. Commun. 9, 4936 (2018).

    ADS  PubMed  PubMed Central  Article  CAS  Google Scholar 

  56. 56.

    Liao, L.-L. et al. Visible-light-driven external-reductant-free cross-electrophile couplings of tetraalkyl ammonium salts. J. Am. Chem. Soc. 140, 17338–17342 (2018).

    CAS  PubMed  Article  Google Scholar 

  57. 57.

    Wang, H., Gao, Y., Zhou, C. & Li, G. Visible-light-driven reductive carboarylation of styrenes with CO2 and aryl halides. J. Am. Chem. Soc. 142, 8122–8129 (2020).

    CAS  PubMed  Article  Google Scholar 

  58. 58.

    Zhou, W.-J. et al. Reductive dearomative arylcarboxylation of indoles with CO2 via visible-light photoredox catalysis. Nat. Commun. 11, 3263–3271 (2020).

    ADS  CAS  PubMed  PubMed Central  Article  Google Scholar 

  59. 59.

    Huang, H. et al. Visible-light-driven anti-markovnikov hydrocarboxylation of acrylates and styrenes with CO2. CCS Chem. 2, 1746–1756 (2020).

    Article  Google Scholar 

  60. 60.

    Ishitani, O., Yanagida, S., Takamuku, S. & Pac, C. Redox-photosensitized reactions. 13. Ru(bpy)32+-photosensitized reactions of an NADH model, 1-benzyl-1,4-dihydronicotinamide, with aromatic carbonyl compounds and comparison with thermal reactions. J. Org. Chem. 52, 2790–2796 (1987).

    CAS  Article  Google Scholar 

  61. 61.

    Isse, A. A. & Gennaro, A. Mechanism of the electrochemical carboxylation of aromatic ketones in dimethylformamide. Collect. Czech. Chem. Commun. 68, 1379–1394 (2003).

    CAS  Article  Google Scholar 

  62. 62.

    Lu, Y. et al. Nanostructured electrocatalysts for electrochemical carboxylation with CO2. Nano Sel. 1, 135–151 (2020).

    ADS  Article  Google Scholar 

  63. 63.

    Zhang, W.-Z. et al. Sequential carboxylation/intramolecular cyclization reaction of o-alkynyl acetophenone with CO2. Org. Chem. Front. 1, 275–283 (2014).

    CAS  Article  Google Scholar 

  64. 64.

    Mahrwald, R. (ed). Modern Aldol Reactions (Wiley-VCH, 2004).

  65. 65.

    Geissman, T. A. Cannizzaro reaction. Org. React. 2, 94–113 (1944).

    Google Scholar 

  66. 66.

    Speckmeier, E., Fischer, T. G. & Zeitler, K. A toolbox approach to construct broadly applicable metal-free catalysts for photoredox chemistry: deliberate tuning of redox potentials and importance of halogens in donor-acceptor cyanoarenes. J. Am. Chem. Soc. 140, 15353–15365 (2018).

    CAS  PubMed  Article  Google Scholar 

  67. 67.

    Masuda, Y., Ishida, N. & Murakami, M. Light-driven carboxylation of o-alkylphenyl ketones with CO2. J. Am. Chem. Soc. 137, 14063–14066 (2015).

    CAS  PubMed  Article  Google Scholar 

  68. 68.

    Juhl, M. & Lee, J.-W. Umpolung reactivity of aldehydes toward carbon dioxide. Angew. Chem. Int. Ed. 57, 12318–12322 (2018).

    CAS  Article  Google Scholar 

  69. 69.

    Juhla, M., Kimb, M. J., Lee, H.-Y., Baik, M.-H. & Lee, J.-W. Aldehyde carboxylation: a concise DFT mechanistic study and a hypothetical role of CO2 in the origin of life. Synlett 30, 987–996 (2019).

    Article  CAS  Google Scholar 

  70. 70.

    Ju, T. et al. Dicarboxylation of alkenes, allenes and (hetero)arenes with CO2 via visible-light photoredox catalysis. Nat. Catal. 4, 304–311 (2021).

    Article  Google Scholar 

  71. 71.

    Lowry, M. S. et al. Single-layer electroluminescent devices and photoinduced hydrogen production from an ionic iridium(III) complex. Chem. Mater. 17, 5712–5719 (2005).

    CAS  Article  Google Scholar 

  72. 72.

    Kise, N., Agui, S., Morimoto, S. & Ueda, N. Electroreductive acylation of aromatic ketones with acylimidazoles. J. Org. Chem. 70, 9407–9410 (2005).

    CAS  PubMed  Article  Google Scholar 

  73. 73.

    Yan, M., Kawamata, Y. & Baran, P. S. Synthetic organic electrochemical methods since 2000: on the verge of a renaissance. Chem. Rev. 117, 13230–13319 (2017).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  74. 74.

    Lamy, E., Nadjo, L. & Saveant, J. M. Standard potential and kinetic parameters of the electrochemical reduction of carbon dioxide in dimethylformamide. J. Electroanal. Chem. 78, 403–407 (1977).

    CAS  Article  Google Scholar 

  75. 75.

    Zhu, J., Yuan, Y., Wang, S. & Yao, Z.-J. Synthesis of 2,3-dialkylated tartaric acid esters via visible light photoredox-catalyzed reductive dimerization of α-ketoesters. ACS Omega 2, 4665–4677 (2017).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  76. 76.

    Song, L. et al. Visible‐light photoredox‐catalyzed remote difunctionalizing carboxylation of unactivated alkenes with CO2. Angew. Chem. Int. Ed. 59, 21121–21128 (2020).

    CAS  Article  Google Scholar 

  77. 77.

    Koyanagi, J., Kamei, T., Ishizaki, M., Nakamura, H. & Takahashi, T. Improved synthetic route to methyl 1-fluoroindan-1-carboxylate (FICA Me ester) and 4-methyl derivatives. Chem. Pharm. Bull. 62, 816–819 (2014).

    CAS  Article  Google Scholar 

  78. 78.

    Ichiyanagi, T. & Yamasaki, R. Anomeric O-acylation of Kdo using alkyl and aryl isocyanates. Carbohydr. Res. 340, 2682–2687 (2005).

    CAS  PubMed  Article  Google Scholar 

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Financial support provided by the National Natural Science Foundation of China (21822108 and 21772129), Sichuan Science and Technology Program (20CXTD0112 and 2020YFH0083), Open Research Fund of Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Fundamental Research Funds from Sichuan University (2020SCUNL102), and the Fundamental Research Funds for the Central Universities. We also thank Xiaoyan Wang from the Analysis and Testing Center of Sichuan University and the comprehensive training platform of the Specialized Laboratory in the College of Chemistry at Sichuan University for compound testing.

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D.G.Y. conceived and designed the study, and wrote the manuscript. G.M.C., X.L.H., L.L.L., S.S.Y., L.S., and L.G. performed the experiments, mechanistic studies, and revised the manuscript. J.J.C. co-guided the research and revised the manuscript. All authors contributed to the analysis and interpretation of the data.

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Correspondence to Da-Gang Yu.

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Cao, GM., Hu, XL., Liao, LL. et al. Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2. Nat Commun 12, 3306 (2021).

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