Small organic radicals are ubiquitous intermediates in photocatalysis and are used in organic synthesis to install functional groups and to tune electronic properties and pharmacokinetic parameters of the final molecule. Development of new methods to generate small organic radicals with added functionality can further extend the utility of photocatalysis for synthetic needs. Herein, we present a method to generate dichloromethyl radicals from chloroform using a heterogeneous potassium poly(heptazine imide) (K-PHI) photocatalyst under visible light irradiation for C1-extension of the enone backbone. The method is applied on 15 enones, with γ,γ-dichloroketones yields of 18–89%. Due to negative zeta-potential (−40 mV) and small particle size (100 nm) K-PHI suspension is used in quasi-homogeneous flow-photoreactor increasing the productivity by 19 times compared to the batch approach. The resulting γ,γ-dichloroketones, are used as bifunctional building blocks to access value-added organic compounds such as substituted furans and pyrroles.
Carbon nitrides (CNs) are “all-in-one” photocatalysts that mediate dozens of different photocatalytic reactions and enable bifunctionalization of (hetero)arenes in one pot1. The organic semiconductors have also been efficiently employed in a continuous flow system for chemical synthesis eliminating the last obstacle (poor light penetration in heterogeneous solid-liquid mixture) on the way to widespread applications in organic synthesis2. Because of their low cost, ease of synthesis and stability against reactive intermediates and photobleaching, CNs already play an important role as heterogeneous photocatalysts for organic transformations3,4,5. CNs are also very versatile, and can be tailored depending on the application by bandgap engineering at the atomic and molecular level6,7.
Most photocatalytic reactions are based on single electron transfer between the reagents and the photocatalyst8. Therefore, reactive open shell species are ubiquitous intermediates in photocatalytic processes9,10,11. Small organic radicals, such as CH3, CF3, CHF21, and perfluoroalky12, CH3O13 etc. are used for the functionalization of the organic molecules in order to tune steric and electronic properties. Furthermore, the lipophilicity and metabolic stability of pharmaceuticals may be adjusted in this way14,15. Despite their importance for medicinal chemistry, CF3, alkyl, and CH3O groups are chemically stable. Therefore, further diversification of the molecule at these newly formed sites is problematic. For example, cleavage of C–F bond in CF3-group is extremely demanding16. The same applies to C–O bond in the CH3O-group17,18.
Conversely CHCl2 radical from the pool of small organic radicals is synthetically more useful. It enables the installation of an electrophilic carbon, and the C–Cl bonds can be conveniently cleaved using weak nucleophiles. In other words, the CHCl2 radical allows for C1-extension of the substrate framework, while simultaneously adding a chemically active functionality19. From this point of view, the CHCl2 radical can be regarded as a “small functional radical”.
Despite the obvious synthetic utility of the dichloromethyl radical, literature is still lacking reactions using dichloromethyl moieties in conjugate additions—the kind of reaction resembling a traditional polar Michael addition. The latter was well studied in photoredox catalysis20,21,22,23. An example shown in Fig. 1a employs methyl groups in tertiary amines and C=C double bond as coupling partners. The chemistry of dichloromethyl radicals is restricted to a few examples, while such radicals are generated predominantly by catalyst containing rare precious metals or dangerous chemicals (Fig. 1b, c). Our alternative approach uses cheap heterogenous carbon nitride (CN) photocatalysts (1–10 Euro per gram on a gram-scale synthesis)24 and have a low toxicity25.
We hypothesized that chloroform can be used as atom efficient source of CHCl2 radicals. Although chloroform readily gives dichlorocarbene in the presence of strong bases, we concede that photocatalyst will alter the path of chloroform decomposition. Formation of the dichloromethyl radical thereby may be achieved by one-electron reduction of chloroform followed by elimination of a chloride anion.
In order to trigger this process, we chose potassium poly(heptazine imide) (K-PHI), a member of the CN family26. Upon irradiation with visible light, metastable long-lived radicals are generated that have been used as a pool of electrons to reduce different substrates27. Earlier, we developed photocatalytic methods to synthesize thioamides28, dibenzyl sulfanes29, 1,3,4-oxadiazoles3, N-fused pyrroles30, cyclopentanes27, and halogenated aromatic hydrocarbons using K-PHI31. In related works, the long-lived carbon nitride radicals were applied in the delayed evolution of hydrogen32,33.
Due to the advantages of flow reactors34,35, several types of such photoreactors employing carbon nitrides have been reported—packed bed photoreactor36, serial micro batch photoreactors2, and triphasic flow photoreactor37. Due to relatively small particle size (average diameter 100 nm) and highly negative zeta-potential (−40 mV)38, K-PHI gives stable colloidal solution and has been used in quasi-homogeneous catalysis39. Due to these features colloidal solution of K-PHI can be used in simple plug-flow photoreactors that are designed for homogeneous reaction mixtures.
All in all, we present an unusual photocatalyzed radical addition of dichloromethyl radicals to enones to form a new C–C bond (Fig. 1d). In this approach chloroform is used as a source of dichloromethyl radicals. The reaction is catalyzed by K-PHI using blue light irradiation. Using the discovered reaction, we show that light scattering by semiconductor particulate strongly affects their performance in batch reactors limiting the scalability of such transformations. A nineteen times higher productivity is achieved using a dedicated flow photoreactor employing quasi-homogeneous K-PHI nanoparticles. Finally, dichloromethyl adducts, i.e., γ,γ-dichloroketones, are used to access bifunctional building blocks and several classes of heterocyclic compounds.
Optimization of reaction conditions
Along these arguments, we studied the designed reaction between chalcone 1a, chloroform, tetrahydroisoquinoline (THIQ) as an electron donor and K-PHI as the photocatalyst (see SI for preparation and characterization of K-PHI, Supplementary Fig. 1). Dichloroketone 2a was synthesized initially with 17% yield when 1 equivalent of THIQ was used (Table 1, entry 1). By increasing the amount of THIQ gradually to four equivalents, the yield of 2a was increased to 51% (entry 3). However, even higher yield (62%) of 2a was achieved by using 3 equivalents of triethanolamine (TEOA) as electron donor (entry 4). The optimum conditions include ten equivalents of TEOA, under which we achieved 97% yield (entry 5). The reaction does not proceed without catalyst, light or a sacrificial electron donor (entry 6–8). CDCl3 is a suitable source of CDCl2 radicals offering a route for d-labeled dichloroketones 2a-d1 with 99% yield (entry 9). We also evaluated the robustness of the reaction using different alcohols as hole scavengers, observing the formation of the desired product in all cases, albeit in lower yield (Table S1, entry 11–14). These results illustrate the better ability of amines to donate electrons compared to alcohols, due to lower oxidation potentials (e.g., +0.5 V for TEOA, +1.5 V for benzyl alcohol and +1.9 V for MeOH, EtOH, iPrOH (Supplementary Note 1). It is also supported by higher H2 production rate over carbon nitride materials using TEOA as electron donor compared to MeOH and EtOH40,41 and comparative tests of benzyl alcohol oxidation versus benzylamine37,42. Moderate heating (50 °C) facilitates the reaction, as the yield of 2a was 64% when reaction was performed at 20 °C (Supplementary Table 1, entry 21). We also compared the catalytic activity of other materials and photoredox complexes. Na-PHI gave 2a with 49% yield (entry 10)43. Similar behavior was already observed during the photocatalytic synthesis of thioamides28. Mesoporous graphitic carbon nitride (mpg-CN) gave 2a with comparable yield 85% (entry 11). The inorganic semiconductors CdS and TiO2 gave 2a in 70 and 94% yield, respectively (entries 12,13). Homogeneous Ir(ppy)3 gave 2a with 97% yield (entry 14), while [Ru(bpy)3]Cl2 only resulted in 8% of 2a (entry 15). Furthermore, it was also shown that recycled K-PHI remains photocatalytically active for at least two further cycles (Supplementary Table 2).
Using the optimized conditions fifteen dichloroketones have been isolated with 18–89% yield (Figs. 2a–o). The characterization of products was conducted by NMR analysis. Dichloroketones 2 do not give stable molecular ions in the mass spectra (electron ionization). For example, the expected m/z value for 2a is 292. However, a signal with m/z 221 was detected (Supplementary Fig. 2). The latter corresponds to 2,4-diphenylfuran. In general 2,4-diarylsubstituted furans are products of oxygen nucleophilic attack at CHCl2-group followed by elimination of two molecules HCl under the conditions of GC-MS data acquisition. Below we employ the reactivity of CHCl2 group in synthesis of pyrroles and furans. Nonetheless, elemental analysis of 2a revealed chlorine content in excellent agreement with the calculated content confirming the proposed structure. We further proved the product structure, using deuterated chloroform as dichloromethyl source, observing the rise of the triplet in the 13C NMR spectrum in the d-labeled compound (2a-d1).
Dichloromethylated chalcones bearing strong electron withdrawing groups, i.e., CN–, MeO2C–, and pyridin-2-yl, 1p–r, gave the corresponding products 2p-r in low yields as analyzed by 1H-NMR spectrometry of the crude reaction mixture (Supplementary Note 2). Nevertheless, we envision toolbox of synthetic organic chemistry to be useful for further diversification of the products structures employing, for example, methyl-group in 2b, F-atoms in 2d,e,h and intrinsically reactive sites in 2i,j. Common reactive Michael acceptors, such as methyl vinyl ketone and acrylonitrile, gave only trace amounts of CHCl2 addition to the double bond as evidenced by GC-MS (Supplementary Note 3). Even more reactive Michael acceptors, i.e., methacrolein, methyl acrylate, and 2-furanone, gave a complex mixture and the desired products could not be identified (Supplementary Note 4).
Analysis of the substrates scope suggests that diarylsubstituted enones in general are more suitable substrates for photocatalytic dichloromethylation than terminal alkenes. Nevertheless, the advantages of the developed method are a simpler protocol and safer conditions. For example, the synthesis of 2a and 2l was described earlier using exotic reagents such as dichloromethyllithium44. A comparison of K-PHI, mpg-CN, and Ir(ppy)3 photocatalysts using selected enones, 1i–l, n, p, revealed that K-PHI in general gives the products in higher yields.
In the course of studying suitable reagents to install CxHalyHz-groups in the enone 1a, we tested other halogenated reagents, including dichloromethane, bromoform, iodoform, 1,1,2,2-tetrachloroethane and tetrachloromethane (Supplementary Table 1). Careful analysis of the reaction mixture revealed that addition of CHBr2-groups, CHI2-groups, and C2HCl4-groups to enone 1a indeed took place. However, the products are not stable and undergo further chemical transformations, such as HX elimination and subsequent cyclizations to 2,4-diphenylfuran (in case of bromoform and iodoform) or dichlorodihydropyranes (in case of tetrachloroethane) (Supplementary Note 5). Compared to bromoform and iodoform, chloroform is beneficial due to higher selectivity in the reaction of enones C1 backbone extension.
Scaling the dichloromethylation reaction of 1a in batch led to gradual decrease of the dichloroketone yield, from 88% (on 0.05 mmol scale) to 23% (on 5 mmol scale) (Supplementary Table 3). After careful investigation, we concluded that the origin for such drastic drop of the product 2a yield is poor light penetration in the depth of the batch reactor due to light scattering by suspended semiconductor particles (Supplementary Note 6)45.
Quasi-homogeneous flow photoreactor
In order to overcome limitations of the batch approach, we performed the reaction in a continuous flow reactor made out of thin (inner diameter 1.6 mm) fluorinated ethylene propylene (FEP) tubing (Fig. 3). The use of carbon nitrides has been reported in serial micro-batch reactors2, that use gas-liquid segments to avoid clogging. A simplified system is applicable for K-PHI due to relatively small particle diameter (100 nm) and negative zeta-potential (ζ) (Fig. 3a). Electrostatic stabilization allows pumping colloidal solution (Fig. 3b and Supplementary Note 7) without using a gas-liquid system (Fig. 3c). Using flow approach, 2a was obtained with 57% yield. Considering convenience of K-PHI suspension pumping through thin FEP tubing along with easiness of the photocatalyst recovery, the entire system enables quasi-homogeneous photocatalysis in flow39.
As seen from the light intensity measurements (Fig. 3d–f), the FEP tubing filled with the reaction mixture absorbs 74% [(I0 − IT2)/IT0] of light. These results suggest that by performing the reaction in flow, more homogeneous irradiation of K-PHI particulate is achieved compared to the reaction in batch (Supplementary Note 6). Furthermore, we solved the problem of poor light permeability through a semiconductor suspension and increased the productivity of γ,γ-dichloroketone 2a synthesis by a factor of 19.
Application of γ,γ-dichloroketones in organic synthesis
Finally, the γ,γ-dichloroketones obtained by the photocatalytic generation and addition of dichloromethyl radicals to enones were used to install other reactive functional groups. As a practical example, dichloroketone 2a was converted to β-formyl ketone 3a by simple hydrolysis with 60% yield (Fig. 4). The ketoaldehyde 3a was then transformed into multi-substituted heterocycles (4a–6a) using microwave assisted condensations with a series of nucleophiles. For instance, furan and pyrrole scaffolds have been used in synthesis of bioactive substances46,47.
To support the role of chloroform as electron acceptor, we developed a method for oxidative coupling of benzylamines (Fig. 5)48. As example, we synthesized four imines with 83–100% yield. These results offer an alternative route for such transformations using chloroform as a solvent and electron acceptor (Supplementary Fig. 3 for detailed mechanism of amines coupling).
The proposed mechanism of the reported photocatalytic reaction is shown in Fig. 6. In the first step, K-PHI is excited by blue photons giving excited state of the photocatalyst (K-PHI*). Removal of an electron from TEOA by K-PHI* (reductive quenching of the photocatalyst), leads to the formation of the long-lived radical anion K-PHI•−, that has the typical deep green color27,29. Chloroform is subsequently oxidized by a single electron transfer event, forming the chloroform radical anion that eliminates a chloride anion resulting in a dichloromethyl radical. Addition of the dichloromethyl radical to the β-carbon atom of the enone gives intermediate i−1. Abstraction of hydrogen from TEOA leads to the desired product 2. While TEOA acts as hole scavenger, chloroform simultaneously acts as solvent and electron acceptor to complete the photocatalytic cycle, as it was already proposed by Chen et al.49 It is also possible to detect traces of different chlorinated compounds, that result from side radical reactions of the dichloromethyl radical, via GC-MS. By running experiments in the absence of the enone, we observed the formation of halogenated compounds including tetrachloroethane that is likely formed via a homocoupling of dichloromethyl radicals (Supplementary Table 4; Supplementary Figs. 4, 5, 6).
In this work, we extended the library of small organic radicals available for photocatalytic synthesis to dichloromethyl radicals than can be conveniently generated from chloroform. The method was validated in a 1,4 addition of dichloromethyl radicals to enones. The process is photocatalyzed by the heterogeneous, metal free carbon nitride photocatalyst K-PHI. Fifteen γ,γ-dichloroketones were isolated in moderate to excellent yield. The possibility to use other polyhalogenated compounds such as bromoform, iodoform and 1,1,2,2-tetrachloroethane has been demonstrated. Light scattering by carbon nitride particles has been identified as limiting factor for scaling these transformations. The results suggest that, in a typical photocatalytic experiment using 2.5 mg mL−1 of semiconductor particles, the penetration depth of light is only 3 mm. In polar solvent, such as DMSO, nanoparticles of K-PHI give stable suspension that was pumped through a thin (1.6 mm internal diameter) tubing. γ,γ-dichloroketone 2a has been also synthesized using quasi-homogeneous photoreactor. The γ,γ-dichloroketones obtained in this work were proved to be useful building blocks with applications in the synthesis of bifunctional compounds that can be used for the preparation of heterocyclic bioactive molecules. The use of chloroform as solvent and electron acceptor was also demonstrated in the oxidative coupling of benzylamines.
Experiments were carried out in a CEM Discover® SP System microwave reactor.
1H and 13C NMR spectra were recorded on Agilent 400 MHz (at 400 MHz for Protons and 101 MHz for Carbon-13). Chemical shifts are reported in ppm versus solvent residual peak: chloroform-d 7.26 ppm (1H NMR), 77.1 ppm (13C NMR); acetonitrile-d3 1.94 ppm (1H NMR), 118.3 ppm (13C NMR).
Mass spectral data were obtained using Agilent GC 6890 gas chromatograph, equipped with HP-5MS column (inner diameter = 0.25 mm, length = 30 m, and film = 0.25 μm), coupled with Agilent MSD 5975 mass spectrometer (electron ionization).
Cyclic voltammetry (CV) measurements were performed in a glass single-compartment electrochemical cell. Glassy carbon (diameter 3 mm) was used as a working electrode (WE), Ag wire in AgNO3 (0.01 M) with tetrabutylammonium perchlorate (0.1 M) in MeCN as a reference electrode (RE), Pt wire as a counter electrode. Each compound was studied in a 50 mM concentration in a 0.1 M tetrabutylammonium perchlorate (TBAP)/chloroform electrolyte solution (10 mL). Before voltammograms were recorded, the solution was purged with Ar, and an Ar flow was kept in the headspace volume of the electrochemical cell during CV measurements. A potential scan rate of 0.050 V s−1 was chosen, and the potential window ranging from +2.5 V to −2.5 V (and backwards) was investigated. Cyclic voltammetry was performed under room-temperature conditions (~20–22 °C).
Zeta-potentials were measured in aqueous colloidal solution of K-PHI using a Malvern Zetasizer instrument.
Hydrodynamic diameter of K-PHI particles in water was measured using Malvern Zetasizer instrument.
General method for dichloro-ketone preparation (2a–l)
A glass tube with rubber-lined cap was evacuated and filled with argon three times. To this tube triethanolamine (74.6 mg, 66 µL, 0.5 mmol), corresponding chalcone (50 µmol), K-PHI (5 mg) and chloroform (2 mL) were added. Resulting mixture was stirred at 50 °C under irradiation of Blue LED (λ = 461 nm) for 20 h. Then reaction mixture was cooled to room temperature and centrifuged, clear solution was separated and solid residue was washed with chloroform (2 mL) and centrifuged again. Organic solutions were combined and evaporated to dryness. Residue after evaporation was purified by silica gel column chromatography using mixture of hexane/diethyl ether (98:2) as an eluent.
This study does not use custom computer code or algorithm to generate results that are reported in the paper and central to its main claims.
Ghosh, I. et al. Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes. Science 365, 360–366 (2019).
Pieber, B., Shalom, M., Antonietti, M., Seeberger, P. H. & Gilmore, K. Continuous heterogeneous photocatalysis in serial micro-batch reactors. Angew. Chem. Int. Ed. 57, 9976–9979 (2018).
Kurpil, B., Otte, K., Antonietti, M. & Savateev, A. Photooxidation of N-acylhydrazones to 1,3,4-oxadiazoles catalyzed by heterogeneous visible-light-active carbon nitride semiconductor. Appl. Catal. B 228, 97–102 (2018).
Savateev, A., Ghosh, I., König, B. & Antonietti, M. Photoredox catalytic organic transformations using heterogeneous carbon nitrides. Angew. Chem. Int. Ed. 57, 15936–15947 (2018).
Markushyna, Y., Smith, C. A. & Savateev, A. Organic photocatalysis: carbon nitride semiconductors vs. molecular catalysts. Eur. J. Org. Chem. https://doi.org/10.1002/ejoc.201901112 (2019).
Cao, S., Low, J., Yu, J. & Jaroniec, M. Polymeric photocatalysts based on graphitic carbon nitride. Adv. Mater. 27, 2150–2176 (2015).
Savateev, A. et al. Synthesis of an electronically modified carbon nitride from a processable semiconductor, 3-amino-1,2,4-triazole oligomer, via a topotactic-like phase transition. J. Mater. Chem. A 5, 8394–8401 (2017).
Kisch, H. Semiconductor photocatalysis–mechanistic and synthetic aspects. Angew. Chem. Int. Ed. Engl. 52, 812–847 (2013).
Stephenson, C., Yoon, T. & MacMillan, D. W. C. Visible Light Photocatalysis in Organic Chemistry (Wiley, 2018).
Dvoranova, D., Barbierikova, Z. & Brezova, V. Radical intermediates in photoinduced reactions on TiO2 (an EPR spin trapping study). Molecules 19, 17279–17304 (2014).
Nagib, D. A. & Macmillan, D. W. C. Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. Nature 480, 224–228 (2011).
Baar, M. & Blechert, S. Graphitic carbon nitride polymer as a recyclable photoredox catalyst for fluoroalkylation of arenes. Chem. Eur. J. 21, 526–530 (2015).
Zhao, Y., Shalom, M. & Antonietti, M. Visible light-driven graphitic carbon nitride (g-C3N4) photocatalyzed ketalization reaction in methanol with methylviologen as efficient electron mediator. Appl. Catal. B 207, 311–315 (2017).
Filler, R., Kobayashi, Y. & Yagupolskii, L. Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications (Elsevier Science LTD, 1993).
Zafrani, Y. et al. Difluoromethyl bioisostere: examining the “Lipophilic Hydrogen Bond Donor” concept. J. Med. Chem. 60, 797–804 (2017).
Mai, V. H. & Nikonov, G. I. Hydrodefluorination of fluoroaromatics by isopropyl alcohol catalyzed by a ruthenium NHC complex. An unusual role of the carbene ligand. ACS Catal. 6, 7956–7961 (2016).
Waghmode, S. B., Mahale, G., Patil, V. P., Renalson, K. & Singh, D. Efficient method for demethylation of aryl methyl ether using aliquat-336. Synth. Commun. 43, 3272–3280 (2013).
Rebacz, N. A. & Savage, P. E. Anisole hydrolysis in high temperature water. Phys. Chem. Chem. Phys. 15, 3562–3569 (2013).
Zhang, J., Xing, C., Tiwari, B. & Chi, Y. R. Catalytic activation of carbohydrates as formaldehyde equivalents for stetter reaction with enones. J. Am. Chem. Soc. 135, 8113–8116 (2013).
Kohls, P., Jadhav, D., Pandey, G. & Reiser, O. Visible light photoredox catalysis: generation and addition of N -aryltetrahydroisoquinoline-derived α-amino radicals to michael acceptors. Org. Lett. 14, 672–675 (2012).
Ruiz Espelt, L., Wiensch, E. M. & Yoon, T. P. Brønsted acid cocatalysts in photocatalytic radical addition of α-amino C–H bonds across michael acceptors. J. Org. Chem. 78, 4107–4114 (2013).
Ruiz Espelt, L., McPherson, I. S., Wiensch, E. M. & Yoon, T. P. Enantioselective conjugate additions of α-amino radicals via cooperative photoredox and Lewis acid catalysis. J. Am. Chem. Soc. 137, 2452–2455 (2015).
Murphy, J. J., Bastida, D., Paria, S., Fagnoni, M. & Melchiorre, P. Asymmetric catalytic formation of quaternary carbons by iminium ion trapping of radicals. Nature 532, 218–222 (2016).
Savateev, A. & Antonietti, M. Ionic carbon nitrides in solar hydrogen production and organic synthesis: exciting chemistry and economic advantages. ChemCatChem 11, 6166–6176 (2019).
Cui, Q. et al. Phenyl-modified carbon nitride quantum dots with distinct photoluminescence behavior. Angew. Chem. Int. Ed. 55, 3672–3676 (2016).
Kurpil, B. et al. Hexaazatriphenylene doped carbon nitrides—biomimetic photocatalyst with superior oxidation power. Appl. Catal. B 217, 622–628 (2017).
Kurpil, B., Markushyna, Y. & Savateev, A. Visible-light-driven reductive (Cyclo)dimerization of chalcones over heterogeneous carbon nitride photocatalyst. ACS Catal. 9, 1531–1538 (2019).
Kurpil, B., Kumru, B., Heil, T., Antonietti, M. & Savateev, A. Carbon nitride creates thioamides in high yields by the photocatalytic Kindler reaction. Green. Chem. 20, 838–842 (2018).
Savateev, A., Kurpil, B., Mishchenko, A., Zhang, G. & Antonietti, M. A. “waiting” carbon nitride radical anion: a charge storage material and key intermediate in direct C–H thiolation of methylarenes using elemental sulfur as the “S”-source. Chem. Sci. 9, 3584–3591 (2018).
Kurpil, B. et al. Carbon nitride photocatalyzes regioselective aminium radical addition to the carbonyl bond and yields N-fused pyrroles. Nat. Commun. 10, 945–945 (2019).
Markushyna, Y. et al. Halogenation of aromatic hydrocarbons by halide anion oxidation with poly(heptazine imide) photocatalyst. Appl. Catal. B 248, 211–217 (2019).
Ou, H., Tang, C., Chen, X., Zhou, M. & Wang, X. Solvated electrons for photochemistry syntheses using conjugated carbon nitride polymers. ACS Catal. 9, 2949–2955 (2019).
Lau VWh et al. Dark photocatalysis: storage of solar energy in carbon nitride for time-delayed hydrogen generation. Angew. Chem. Int. Ed. 56, 510–514 (2017).
Plutschack, M. B., Pieber, B., Gilmore, K. & Seeberger, P. H. The Hitchhiker’s guide to flow chemistry. Chem. Rev. 117, 11796–11893 (2017).
Movsisyan, M. et al. Taming hazardous chemistry by continuous flow technology. Chem. Soc. Rev. 45, 4892–4928 (2016).
Woźnica, M., Chaoui, N., Taabache, S. & Blechert, S. THF: an efficient electron donor in continuous flow radical cyclization photocatalyzed by graphitic carbon nitride. Chem. Eur. J. 20, 14624–14628 (2014).
Bajada M. et al. Visible light flow reactor packed with porous carbon nitride for aerobic substrate oxidations. ACS Appl. Mater. Interfaces https://doi.org/10.1021/acsami.9b19718 (2020).
Rodríguez, N. A., Savateev, A., Grela, M. A. & Dontsova, D. Facile synthesis of potassium poly(heptazine imide) (PHIK)/Ti-based metal–organic framework (MIL-125-NH2) composites for photocatalytic applications. ACS Appl. Mater. Interfaces 9, 22941–22949 (2017).
Krivtsov, I. et al. Water-soluble polymeric carbon nitride colloidal nanoparticles for highly selective quasi-homogeneous photocatalysis. Angew. Chem. Int. Ed. 59, 487–495 (2020).
Jones, W. et al. A comparison of photocatalytic reforming reactions of methanol and triethanolamine with Pd supported on titania and graphitic carbon nitride. Appl. Catal. B 240, 373–379 (2019).
Zhang, G. et al. Electron deficient monomers that optimize nucleation and enhance the photocatalytic redox activity of carbon nitrides. Angew. Chem. Int. Ed. 58, 14950–14954 (2019).
Samanta, S., Khilari, S., Pradhan, D. & Srivastava, R. An efficient, visible light driven, selective oxidation of aromatic alcohols and amines with O2 using BiVO4/g-C3N4 nanocomposite: a systematic and comprehensive study toward the development of a photocatalytic process. ACS Sustain. Chem. Eng. 5, 2562–2577 (2017).
Chen, Z. et al. “The Easier the Better” preparation of efficient photocatalysts-metastable poly(heptazine imide) salts. Adv. Mater. 29, 1700555 (2017).
Maruoka, K., Shimada, I., Imoto, H. & Yamamoto, H. Conjugate addition of reactive carbanions to α,β-unsaturated ketones in the presence of ATPH. Synlett 1994, 519–520 (1994).
Serpone, N. Relative photonic efficiencies and quantum yields in heterogeneous photocatalysis. J. Photochem. Photobiol. A 104, 1–12 (1997).
Francesconi, I. et al. 2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents. J. Med. Chem. 42, 2260–2265 (1999).
Thompson, B. B. & Montgomery, J. Enone-alkyne reductive coupling: a versatile entry to substituted pyrroles. Org. Lett. 13, 3289–3291 (2011).
Su, F. et al. Aerobic oxidative coupling of amines by carbon nitride photocatalysis with visible light. Angew. Chem. Int. Ed. Engl. 50, 657–660 (2011).
Hu, X. Q. et al. Catalytic N-radical cascade reaction of hydrazones by oxidative deprotonation electron transfer and TEMPO mediation. Nat. Commun. 7, 11188 (2016).
We gratefully acknowledge the Max-Planck Society for generous financial support. The Deutsche Forschungsgemeinschaft is gratefully acknowledged for providing financial support for this project (DFG-An 156 13-1). B.P. acknowledges financial support by a Liebig Fellowship of the German Chemical Industry Fund (Fonds der Chemischen Industrie, FCI). The authors thank Olaf Niemeyer (the head of NMR facility of the MPICI), Michael Born (assembly of LED), Marco Bott (fabrication of the steel cylinder for light source) for technical and scientific support.
The authors declare no competing interests.
Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Mazzanti, S., Kurpil, B., Pieber, B. et al. Dichloromethylation of enones by carbon nitride photocatalysis. Nat Commun 11, 1387 (2020). https://doi.org/10.1038/s41467-020-15131-0
Biomimetic donor-acceptor motifs in carbon nitrides: Enhancing red-light photocatalytic selective oxidation by rational surface engineering
Applied Catalysis B: Environmental (2021)
Metal-Free Photocatalysis: Two-Dimensional Nanomaterial Connection toward Advanced Organic Synthesis
ACS Nano (2021)
Mild adsorption of carbon nitride (C3N3) nanosheet on a cellular membrane reveals its suitable biocompatibility
Colloids and Surfaces B: Biointerfaces (2021)
General surface grafting strategy-derived carbon-modified graphitic carbon nitride with largely enhanced visible light photocatalytic H2 evolution coupled with benzyl alcohol oxidation
Journal of Materials Chemistry A (2021)
Mizoroki–Heck type reactions and synthesis of 1,4-dicarbonyl compounds by heterogeneous organic semiconductor photocatalysis
Green Chemistry (2021)