Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

The Original Article was published on 26 April 2019

Addendum to: Nature Communications, published online 26 April 2019.

The authors have become aware that ‘BTR pseudo-site 2’ inadvertently contains two incorrect nucleotides and does not match the sequence of the pseudo-site in the human genome. The data points corresponding to this construct in Fig. 5e and Supplementary Table 5 are therefore no longer valid. However, the overall conclusion that Rec-seq can predict the activity of site-specific recombinases on endogenous human genomic pseudo-sites of remains unaffected by this error. Updated versions of Fig. 5 and Supplementary Table 5 are presented below as Figures 1 and Table 1 respectively.


Fig. 1

Table 1 Human genomic off-target substrates for Brec1

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Correspondence to David R. Liu.

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Bessen, J.L., Afeyan, L.K., Dančík, V. et al. Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nat Commun 10, 3003 (2019).

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