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Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer

Nature Communicationsvolume 9, Article number: 2660 (2018) | Download Citation

Retraction of: Nature Communications https://doi.org/10.1038/s41467-017-00508-5, published online 05 September 2017

In this Article, we reported that liver X receptors constrain metastatic development of prostate cancer in Pten-null mice.

However, following institutional investigations by Université Clermont Auvergne, it has come to our attention that much of the data reported in the paper were a result of manipulation or fabrication. Specifically, differences in protein expression in western blots presented in Fig. 1e, 3b, g, i, m, and 6b, and Supplementary Figures 2d, 6d, 6h, 7h, 8c, 8d, and 14 were generated by unequal loading of samples. In qPCR experiments presented in Figs. 1f, 3f, 4g, 5h, and 6a, d and Supplementary Figures 2c, 5d, 6g, 8d, 11a-c, and 12b, differences in expression level were manipulated through adjustment of cycle numbers, selection of samples, and data fabrication. Differences in immunostaining in Figs. 2g, k and 7e were obtained by selection of images or manipulation of exposure levels. Observed differences in relative luminescence units in Figs. 3m, 4e, and Supplementary Figures 6f, 7a, 7b, 10, and 11f were due to experiment selection.

In light of these findings, we have no confidence in the accuracy of the reported data and the conclusions of the paper. We therefore wish to retract the paper. We deeply regret these circumstances and apologize to the scientific community.

Author information

Affiliations

  1. Université Clermont Auvergne, Génétique Reproduction et Développement, BP 38, 63001, Clermont-Ferrand, France

    • Anthony Alioui
    • , Julie Dufour
    • , Amandine Septier
    • , Pierre Val
    • , Allan Fouache
    • , David H. Volle
    • , Jean-Marc A. Lobaccaro
    •  & Silvère Baron
  2. CNRS, UMR 6293, Génétique Reproduction et Développement, F-63001, Clermont-Ferrand, France

    • Anthony Alioui
    • , Julie Dufour
    • , Amandine Septier
    • , Pierre Val
    • , Allan Fouache
    • , David H. Volle
    • , Jean-Marc A. Lobaccaro
    •  & Silvère Baron
  3. INSERM, UMR 1103, Génétique Reproduction et Développement, F-63001, Clermont-Ferrand, France

    • Anthony Alioui
    • , Julie Dufour
    • , Amandine Septier
    • , Pierre Val
    • , Allan Fouache
    • , David H. Volle
    • , Jean-Marc A. Lobaccaro
    •  & Silvère Baron
  4. Centre de Recherche en Nutrition Humaine d’Auvergne, F-63001, Clermont-Ferrand, France

    • Anthony Alioui
    • , Julie Dufour
    • , Allan Fouache
    • , David H. Volle
    • , Jean-Marc A. Lobaccaro
    •  & Silvère Baron
  5. Department of Medical Biochemistry, Academic Medical Center, Amsterdam, 1105, AZ, The Netherlands

    • Anthony Alioui
    • , Anke Loregger
    • , Martina Moeton
    •  & Noam Zelcer
  6. Laboratory of Clinical Chemistry, Hospital of Varese, AST_Settelaghi, Varese, Italy

    • Valerio Leoni
  7. Department of Medico-Surgical Sciences and Biotechnology, Sapienza University of Rome, Latina, 04100, Italy

    • Luigi Iuliano
    •  & Chiara Zerbinati
  8. Unit of Immuno-Biotherapy of Melanoma and Solid Tumors, Division of Experimental Oncology, San Raffaele Scientific Institute, Milan, Italy

    • Vincenzo Russo

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Corresponding authors

Correspondence to Jean-Marc A. Lobaccaro or Silvère Baron.

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DOI

https://doi.org/10.1038/s41467-018-04653-3

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