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Addendum: Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis

Nature Communicationsvolume 9, Article number: 1052 (2018) | Download Citation

Addendum to: Nature Communications, published online 21 September 2017

We would like to make our readers aware of the publication by Alvarez-Castelao et al., which reports the original development of the Floxed MetRS L274G mice for the cell-specific labelling of proteins in vivo and provides an in-depth characterisation of these mice1. Breeding pairs of Floxed mice were graciously donated by Erin Schuman and coworkers well in advance of the publication by Alvarez-Castelao et al. Application of this technology to cell transplantation, selective identification of ‘young’ proteins in the setting of heterochronic parabiosis, and array proteomics was developed by the Conboy laboratory.

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  1. 1.

    Alvarez-Castelao, B. et al Cell-type specific metabolic labelling of nascent proteomes in vivo. Nat. Biotech. 35, 1196–1201 (2017).

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    • Yan Liu

    Present address: The 7th affiliated hospital of Sun Yat-Sen University, ShenZhen, Guandong, 510275, China


  1. Department of Bioengineering, UC Berkeley and QB3 Institutes, Berkeley, CA, 94709, USA

    • Yan Liu
    • , Michael J. Conboy
    • , Melod Mehdipour
    • , Yutong Liu
    • , Thanhtra P. Tran
    • , Aaron Blotnick
    • , Prasanna Rajan
    • , Thalie Cavalcante Santos
    •  & Irina M. Conboy


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Correspondence to Irina M. Conboy.

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