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Comparison of the gut microbiome composition between men with Peyronie’s disease and a matched cohort: a pilot study

International Journal of Impotence Research (2023)Cite this article

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Trial Registration Number: IRB 2017-3746. To-date there have been no studies that have attempted to elucidate a connection between the gut microbiome (GM) and Peyronie’s disease (PD). However, there have been numerous studies that have established an association between the GM and other fibrotic diseases [1, 2]. We hypothesize that there is a potential relationship between the GM and PD. The goal of our study is to better characterize any potential relationships.

The study population consisted of individuals who provided informed consent under Institutional Review Board (IRB) 2017–3746. Two groups were included in the study: a group diagnosed with PD and an age-matched control group. Age matching was performed within a range of +/−10 years to ensure comparability in terms of age-related factors. Control group participants were recruited from the Urology clinic and had no history, symptoms or physical exam findings of PD. The inclusion criteria for both groups were as follows: assigned male sex at birth, age 30 years or older, body mass index (BMI) of 35 or lower, and sexual activity with a partner within the past 4 weeks. Exclusion criteria encompassed a known current or past history of malignancy, current use of testosterone or hormone replacement therapy, recent use of steroids or other immunosuppressive therapy within the past 4 weeks, recent antibiotic use within the past 4 weeks, previous scrotal/testicular/penile surgery, hypertension, and presence of pro-inflammatory conditions such as rheumatoid arthritis, inflammatory bowel disease, chronic prostatitis, cardiovascular disease, diabetes mellitus, and peripheral vascular disease, among others.

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Fig. 1: (A–D): Gut microbiome richness and diversity was not significantly different between our Peyronie’s disease and control groups.

Data availability

The raw data from our study is available upon reasonable request.

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Authors and Affiliations

  1. College of Osteopathic Medicine, Kansas City University, Kansas City, MO, USA

    Mohamad M. Osman

  2. Department of Urology, University of California, Irvine Medical Center, Orange, CA, USA

    Muhammed A. Hammad, David W. Barham, Farouk M. El-Khatib, Sharmin Dianatnejad, Jeanie Nguyen, Edward Choi, Qiaqia Wu & Faysal A. Yafi

  3. Viome, Inc., Bellevue, WA/Los Alamos, NM/New York, NY/San Diego, San Diego, CA, USA

    Ryan Toma, Guruduth Banavar, Ying Cai, Pedro Moura, Nan Shen & Momchilo Vuyisich

  4. Department of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA

    Maxwell Towe

  5. Independent Registered Dietitian, Irvine, CA, USA

    Natalie R. Yafi

Authors
  1. Mohamad M. Osman
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  2. Muhammed A. Hammad
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  14. Nan Shen
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  15. Momchilo Vuyisich
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  16. Natalie R. Yafi
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  17. Faysal A. Yafi
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Contributions

MMO made contributions to the research design, helped with the acquisition, analysis, and interpretation of the data, and drafted and revised the paper critically. MAH and DWB revised the paper critically. RT, GB, YC, PM, NS, and MV contributed to analysis and interpretation of the data. FME-K, SD, JN, MT, EC, and QW contributed with the acquisition of the data. NRY and FAY contributed to the research design and revised the paper critically.

Corresponding author

Correspondence to Mohamad M. Osman.

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Competing interests

FRY reports associations with Halozyme as advisory board and speaker; Coloplast as advisory board and speaker; Cynosure as consultant; Promescent as advisory board; Sprout as consultant; Xialla as advisory board; and Viome as clinical trial primary investigator. All other authors declare no competing interests.

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Osman, M.M., Hammad, M.A., Barham, D.W. et al. Comparison of the gut microbiome composition between men with Peyronie’s disease and a matched cohort: a pilot study. Int J Impot Res (2023). https://doi.org/10.1038/s41443-023-00737-x

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  • DOI: https://doi.org/10.1038/s41443-023-00737-x

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