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Use of grafting materials during penile prosthesis implantation in patients with Peyronie’s disease—a systematic review

Abstract

Severe Peyronie’s disease (PD) and concomitant erectile dysfunction (ED) may require plaque incision/excision and grafting (PIG) as an adjunct to penile prosthesis implantation (IPP). Currently, there is no available consensus on the best graft material to use. Our aim was to systematically review graft materials used as patches following PIG + IPP. Literature search was performed in March 2021. Only original articles in English with a series of 10 or more patients were included. Overall, a total of 17 studies were included, corresponding to a cohort of 662 patients. The mean age ranged from 45 to 65 years and most patients had curvatures >45°. Average penile lengthening ranged from 1 to 3.5 cm, average residual curvatures from 0 to 20% and decreased glans sensitivity from 0 to 20%. Eighty to 100% of patients were satisfied with cosmetic and functional results. PIG + IPP with the use of various grafts offers promising results for the treatment of patients suffering from severe PD with concomitant ED. Unfortunately, the absence of high quality and comparative studies makes it difficult to establish the optimum graft. Therefore, the level of experience of the surgical team with one or more methods should guide their choice.

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Acknowledgements

This project is endorsed by the European Association of Urology Research Foundation. FC, MD is supported by The Margaret Spittle Research Fellowship, University College London Hospital, London UK. AM is supported by the NIHR Biomedical Research Centre University College London Hospital.

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FChconception and design, data acquisition, drafting and revision of the manuscript, approval of the final version, CBrevision of the manuscript, approval of the final version, FC-Jdata acquisition, revision of the manuscript, approval of the final version, FCconception and design, data acquisition, revision of the manuscript, approval of the final version, LAK—revision of the manuscript, approval of the final version, CTrevision of the manuscript, approval of the final version, AMrevision of the manuscript, approval of the final version.

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Correspondence to Fabio Castiglione.

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Chierigo, F., Bettocchi, C., Campos-Juanatey, F. et al. Use of grafting materials during penile prosthesis implantation in patients with Peyronie’s disease—a systematic review. Int J Impot Res 34, 534–542 (2022). https://doi.org/10.1038/s41443-021-00479-8

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