Decreased forced expiratory volume in first second is associated with erectile dysfunction in apparently healthy men. A preliminary study.


Although it has been evaluated that even 76% of men with chronic obstructive pulmonary disease suffer from erectile dysfunction, the association has been poorly characterised. The aim of the study was to describe the association between forced expiratory volume in first second and erectile dysfunction in apparently healthy men. All together 331 men aged 45–70 years old were randomly drawn from a cross-sectional population-based study conducted in 2005 in Finland. Decreased forced expiratory volume was defined by performing mini-spirometry and erectile dysfunction by International Index of Erectile Function short form questionnaire. After adjustment for age and depressive symptoms predicted forced expiratory volume (FEV1 < 65%) was associated with 2.66 (95% CI, 1.18–5.99) increased risk of moderate to severe erectile dysfunction (International Index of Erectile Function short form score < 17). Therefore, the authors highlight the importance of erectile and sexual health evaluation and treatment, if necessary, in men with decreased lung function.

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  1. 1.

    NIH Consensus Conference. Impotence. NIH consensus development panel on impotence. J Am Med Assoc. 1993;270:83–90.

    Article  Google Scholar 

  2. 2.

    Green JS, Holden ST, Ingram P, Bose P, St George DP, Bowsher WG. An investigation of erectile dysfunction in Gwent, Wales. BJU Int. 2001;88:551–3.

    CAS  Article  Google Scholar 

  3. 3.

    Imai A, Yamamoto H, Hatakeyama S, Iwabuchi I, Yoneyama T, Hashimoto Y, et al. Risk factors for erectile dysfunction in healthy Japanese men. Int J Androl. 2010;33:569–73.

    CAS  PubMed  Google Scholar 

  4. 4.

    Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil study group. N Engl J Med. 1998;338:1397–404.

    CAS  Article  Google Scholar 

  5. 5.

    Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994;151:54–61.

    CAS  Article  Google Scholar 

  6. 6.

    Mercer CH, Fenton KA, Johnson AM, Wellings K, Macdowall W, McManus S, et al. Sexual function problems and help seeking behaviour in Britain: national probability sample survey. BMJ. 2003;327:426–7.

    Article  Google Scholar 

  7. 7.

    Ettala OO, Syvänen KT, Korhonen PE, Kaipia AJ, Vahlberg TJ, Boström PJ, et al. High-intensity physical activity, stable relationship, and high education level associate with decreasing risk of erectile dysfunction in 1000 apparently healthy cardiovascular risk subjects. J Sex Med. 2014;11:2277–84.

    Article  Google Scholar 

  8. 8.

    Wu C, Zhang H, Gao Y, Tan A, Yang X, Lu Z, et al. The association of smoking and erectile dysfunction: results from the Fangchenggang Area Male Health and Examination Survey (FAMHES). J Androl. 2012;33:59–65.

    Article  Google Scholar 

  9. 9.

    Chen K, Mi H, Gao Y, Tan A, Lu Z, Wu C, et al. Metabolic syndrome: a potential and independent risk factor for erectile dysfunction in the Chinese male population. Urology. 2012;80:1287–92.

    Article  Google Scholar 

  10. 10.

    Vlachopoulos CV, Terentes-Printzios DG, Ioakeimidis NK, Aznaouridis KA, Stefanadis CI. Prediction of cardiovascular events and all-cause mortality with erectile dysfunction: a systematic review and meta-analysis of cohort studies. Circ Cardiovasc Qual Outcomes. 2013;6:99–109.

    Article  Google Scholar 

  11. 11.

    Blanker MH, Bohnen AM, Groeneveld FP, Bernsen RM, Prins A, Thomas S, et al. Correlates for erectile and ejaculatory dysfunction in older Dutch men: a community-based study. J Am Geriatr Soc. 2001;49:436–42.

    CAS  Article  Google Scholar 

  12. 12.

    Fletcher EC, Martin RJ. Sexual dysfunction and erectile impotence in chronic obstructive pulmonary disease. Chest. 1982;81:413–21.

    CAS  Article  Google Scholar 

  13. 13.

    Karadag F, Ozcan H, Karul AB, Ceylan E, Cildag O. Correlates of erectile dysfunction in moderate-to-severe chronic obstructive pulmonary disease patients. Respirology. 2007;12:248–53.

    Article  Google Scholar 

  14. 14.

    Kahraman H, Sen B, Koksal N, Kilinç M, Resim S. Erectile dysfunction and sex hormone changes in chronic obstructive pulmonary disease patients. Multidiscip Respir Med. 2013;8:66.

    Article  Google Scholar 

  15. 15.

    Köseoğlu N, Köseoğlu H, Ceylan E, Cimrin HA, Ozalevli S, Esen A. Erectile dysfunction prevalence and sexual function status in patients with chronic obstructive pulmonary disease. J Urol. 2005;174:249–52. discussion 52.

    Article  Google Scholar 

  16. 16.

    Korhonen P, Aarnio P, Saaresranta T, Jaatinen P, Kantola I. Glucose homeostasis in hypertensive subjects. Hypertension. 2008;51:945–9.

    CAS  Article  Google Scholar 

  17. 17.

    Lindström J, Tuomilehto J. The diabetes risk score: a practical tool to predict type 2 diabetes risk. Diabetes Care. 2003;26:725–31.

    Article  Google Scholar 

  18. 18.

    Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pena BM. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999;11:319–26.

    CAS  Article  Google Scholar 

  19. 19.

    Viljanen AA, Halttunen PK, Kreus KE, Viljanen BC. Spirometric studies in non-smoking, healthy adults. Scand J Clin Lab Invest Suppl. 1982;159:5–20.

    CAS  Article  Google Scholar 

  20. 20.

    Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–71.

    CAS  Article  Google Scholar 

  21. 21.

    Koponen H, Jokelainen J, Keinänen-Kiukaanniemi S, Vanhala M. Depressive symptoms and 10-year risk for cardiovascular morbidity and mortality. World J Biol Psychiatry. 2010;11:834–9.

    Article  Google Scholar 

  22. 22.

    Collins EG, Halabi S, Langston M, Schnell T, Tobin MJ, Laghi F. Sexual dysfunction in men with COPD: impact on quality of life and survival. Lung. 2012;190:545–56.

    Article  Google Scholar 

  23. 23.

    Karadag F, Ozcan H, Karul AB, Yilmaz M, Cildag O. Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease. Int J Clin Pract. 2009;63:275–81.

    CAS  Article  Google Scholar 

  24. 24.

    Maurer J, Rebbapragada V, Borson S, Goldstein R, Kunik ME, Yohannes AM, et al. Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest. 2008;134:43S–56S.

    Article  Google Scholar 

  25. 25.

    Koponen P, Borodulin K, Lundqvist A, Sääksjärvi K, Koskinen S. Terveys, toimintakyky ja hyvinvointi Suomessa: FinTerveys 2017 -tutkimus. National Institution of Health and Welfare, Helsinki, Finland; 2018.

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The work was funded by Central Satakunta Health Federation of Municipalities, Varsinais-Suomi Hospital District, The Finnish Medical Foundation and the Cultural Foundation of Finland.

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Correspondence to Otto O. Ettala.

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The study was assessed and approved by the ethics committee of Satakunta Hospital District. All study participants signed an informed consent.

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Ettala, O.O., Saaresranta, T., Syvänen, K.T. et al. Decreased forced expiratory volume in first second is associated with erectile dysfunction in apparently healthy men. A preliminary study.. Int J Impot Res 32, 420–425 (2020).

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