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NETs: an extracellular DNA network structure with implication for cardiovascular disease and cancer

Hypertension Research volume 47, pages 1260–1272 (2024)Cite this article

Abstract

Cardiovascular (CV) diseases and tumors are best known for its high morbidity and mortality worldwide. There is a growing recognition of the association between CV diseases and tumorigenesis. In addition to CV damage caused by anti-tumor drugs and tumor-induced organ dysfunction, CV events themselves and their treatment may also have a role in promoting tumorigenesis. Therefore, Therefore, the diagnosis and treatment of the two kinds of diseases have entered the era of clinical convergence. Emerging evidence indicates significant biologic overlap between cancer and CV diseases, with the recognition of shared biologic mechanisms. Neutrophil extracellular traps (NETs) represent an immune mechanism of neutrophils promoting the development of tumors and their metastasis. It has been recently demonstrated that NETs exist in various stages of hypertension and heart failure, exacerbating disease progression. At present, most studies focus on the biological role of NETs in CV diseases and tumor respectively, and there are relatively few studies on the specific regulatory mechanisms and effects of NETs in cardiovascular diseases associated with tumors. In this narrative review, we summarize some recent basic and clinical findings on how NETs are involved in the pathogenesis of cardiovascular diseases associated with tumors. We also highlight that the development of treatments targeting NETs may be one of the effective ways to prevent and treat cardiovascular diseases associated with tumors.

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Funding

CS and ZW received relevant funding from the National Natural Science Foundation of China (NSFC 82160089, 82060080), Gansu science and Technology Department Project (23JRRA1641, 23YFFA0038), Lanzhou University Medical Postgraduate Training Innovation Development Project (lzuyxcx-2022-128) and the project of the Cuying Science and Technology Innovation Project (CY2022-YB-A03, CY2022-MS-A06).

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  1. These authors contributed equally: Jianshu Chen, Yuansheng Xu

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  1. Lanzhou University Second Hospital, Lanzhou, 730030, China

    Jianshu Chen, Yuansheng Xu, Fei Yu, Zhengke Ma, Jing Yu & Xiaowei Zhang

  2. Lanzhou University Second College of Clinical Medicine, Lanzhou, 730030, China

    Jing Yu & Xiaowei Zhang

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Chen, J., Xu, Y., Yu, F. et al. NETs: an extracellular DNA network structure with implication for cardiovascular disease and cancer. Hypertens Res 47, 1260–1272 (2024). https://doi.org/10.1038/s41440-023-01574-7

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