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Nighttime blood pressure and glucose control impacts on left ventricular hypertrophy: The Japan Morning Surge Home Blood Pressure (J-HOP) Study

Hypertension Research volume 47, pages 507–514 (2024)Cite this article

Abstract

Several studies investigated the association between nighttime blood pressure (BP) and left ventricular hypertrophy (LVH) in diabetes, but since most of these studies were conducted in diabetes populations only, they did not compare differences in the impact of nighttime BP on LVH in subjects without diabetes. Moreover, data about the impact of glucose control in diabetes on the relationship between nighttime BP and LVH are sparse. We classified 1277 adults (age 64.7 ± 11.8 years) performing ambulatory BP monitoring while enrolled as part of the Japan Morning Surge Home Blood Pressure (J-HOP) study into groups according to the control status of daytime BP (systolic BP [SBP] < 135 mmHg or ≥135 mmHg), nighttime BP (SBP < 120 mmHg or ≥120 mmHg), and diabetes (HbA1c < 7.0% or ≥7.0%). LVH was assessed by echocardiography. LVH according to echocardiographic criteria was identified in 33.7% of the participants. The group with poorly controlled diabetes plus uncontrolled nighttime BP (n = 90) had a 2.1-fold higher risk of LVH compared to the group with controlled nighttime BP and non-diabetes (n = 505) (odds ratio [OR] 2.10, 95% confidence interval [CI]: 1.29–3.44). No association was observed between uncontrolled daytime BP and diabetes for LVH. In the participants with poorly controlled diabetes (n = 146), uncontrolled nighttime BP posed a 3.1-fold higher risk of LVH compared to controlled nighttime BP (OR 3.12, 95%CI: 1.47–6.62). This association was not found in controlled diabetes. Uncontrolled nighttime BP was associated with a risk of LVH, especially among individuals with poorly controlled diabetes.

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Acknowledgements

We gratefully acknowledge the numerous study investigators, fellows, nurses, and research coordinators who participated in the J-HOP study at the various study sites.

Funding

This study was financially supported in part by a grant from the 21st Century Center of Excellence Project run by Japan’s Ministry of Education, Culture, Sports, Science, and Technology (MEXT); a grant from the Foundation for Development of the Community (Tochigi); a grant from Omron Healthcare Co., Ltd; a Grant-in-Aid for Scientific Research (B; 21390247) from The Ministry of Education, Culture, Sports, Science, and Technology of Japan, 2009–2013; and funds from the MEXT-supported program for the Strategic Research Foundation at Private Universities, 2011–2015 Cooperative Basic and Clinical Research on Circadian Medicine (S1101022) to K. Kario. Funding sponsors had no role in forming study design and conducting of the study; the collection, management, analysis, and interpretation of the data; the preparation of the article; and decision to submit the paper for publication.

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  1. Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan

    Shinichi Toriumi, Satoshi Hoshide, Tomoyuki Kabutoya & Kazuomi Kario

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  1. Shinichi Toriumi
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Correspondence to Kazuomi Kario.

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KK has received research grants from Omron Healthcare Co., Ltd., A&D Co., Ltd., and Fukuda Denshi Co., Ltd. The other authors declare that they have no potential competing interests to report.

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Toriumi, S., Hoshide, S., Kabutoya, T. et al. Nighttime blood pressure and glucose control impacts on left ventricular hypertrophy: The Japan Morning Surge Home Blood Pressure (J-HOP) Study. Hypertens Res 47, 507–514 (2024). https://doi.org/10.1038/s41440-023-01487-5

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