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  • Special Features - Renal Denervation and Sympathetic Nerve System
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Current problems in renal denervation and a hope to break the stage

Hypertension Research volume 46, pages 2654–2660 (2023)Cite this article

Abstract

Renal denervation (RDN) is currently confronted with the considerable heterogeneity of different post-procedural blood pressure responses. The challenges predominantly arise from not only the lack of selection of appropriate responders but also the absence of detection for the successful endpoints of intervention. In this paper, we summarize the significant characteristics of potentially appropriate hypertensive patients and propose a hopeful way to improve the accuracy of RDN, that is, the application of three-dimensional reconstruction technology combined with electrical renal nerve stimulation to guide the radiofrequency catheter ablation, which may promote the development of selective and accurate RDN in real-world clinical practice.

This paper focuses on two current critical concerns of renal denervation (RDN): appropriate patient selection and the improvement in the accuracy of selective RDN. A hopeful way of accurate RDN may be the combination of 3D electroanatomic mapping systems for the renal artery with modified renal nerve stimulation (RNS) techniques and technology for appropriate hypertensive candidates.

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Acknowledgements

The authors are grateful to Liang Wang for his graphical artwork.

Funding

This work was partly supported by the National Natural Science Foundation of China (Grant Number: 32071110, YY and Grant Number: 82000471, WC)

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Authors and Affiliations

  1. Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan’an District, Chongqing, China

    Xinyu Hu, Hao Zhou, Weijie Chen, Dan Li, Huaan Du, Tianli Xia & Yuehui Yin

  2. Department of Cardiology, Chongqing University Fuling Hospital, Chongqing, China

    Xinyu Hu

  3. Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China

    Hao Zhou, Weijie Chen, Dan Li, Huaan Du, Tianli Xia & Yuehui Yin

  4. Chongqing Key Laboratory of Arrhythmias, Chongqing, China

    Yuehui Yin

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Correspondence to Yuehui Yin.

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Hu, X., Zhou, H., Chen, W. et al. Current problems in renal denervation and a hope to break the stage. Hypertens Res 46, 2654–2660 (2023). https://doi.org/10.1038/s41440-023-01380-1

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