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Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study

Hypertension Research volume 46, pages 708–719 (2023)Cite this article

Abstract

Prediabetes with hypertension or prehypertension increases the risk of cardiovascular events. Lipid accumulation product (LAP) is a powerful marker of visceral obesity. The current study aimed to explore the relationship between LAP and hypertension and prehypertension among prediabetic individuals. A total of 12,388 prediabetic participants from the REACTION study were recruited. LAP was calculated from waist circumference and fasting triglyceride levels. Multiple logistic regression models were conducted to assess the relationship between LAP and hypertension and prehypertension. Multiple logistic regression analysis showed that elevated LAP was associated with hypertension (Q2: odds ratio (OR): 1.263, P < 0.001; Q3: OR: 1.613, P < 0.001; Q4: OR: 1.754, P < 0.001) and prehypertension (Q2: OR: 1.255, P = 0.005; Q3: OR: 1.340, P = 0.002; Q4: OR: 1.765, P < 0.001). The results of the stratified analysis showed that prediabetic people with higher LAP levels and characterized by overweight, normal weight and a high waist-to-hip ratio (WHR) were more likely to have hypertension, and prediabetic people with higher LAP levels and characterized by overweight, normal weight, a high WHR, age <65, and low and high levels of physical activity were more likely to have prehypertension. In conclusion, visceral obesity assessed by LAP is significantly associated with hypertension and prehypertension in the Chinese prediabetic population.

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Acknowledgements

We would like to thank the participants in this study.

Funding

This study is supported by the Beijing Municipal Science and Technology Commission Project (Z201100005520014).

Author information

Author notes

  1. These authors contributed equally: Binqi Li, Jie Wang.

Authors and Affiliations

  1. School of Medicine, Nankai University, No. 94 Weijin Road, Tianjin, 300071, China

    Binqi Li & Yiming Mu

  2. Department of Endocrinology, First Medical Center of PLA General Hospital, Beijing, China

    Binqi Li & Yiming Mu

  3. Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, P. R. China

    Jie Wang

  4. Graduate School, Chinese PLA General Hospital, Beijing, China

    Xin Zhou & Yiming Mu

  5. Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China

    Xin Zhou

  6. The Second Medical Center of Chinese PLA General Hospital, Beijing, China

    Xin Zhou

  7. Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Weiqing Wang & Guang Ning

  8. Dalian Central Hospital, Dalian, Liaoning, China

    Zhengnan Gao

  9. First Hospital of Lanzhou University, Lanzhou, Gansu, China

    Xulei Tang

  10. Zhongshan University Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong, China

    Li Yan

  11. Southwest Medical University Affiliated Hospital, Luzhou, Sichuan, China

    Qin Wan

  12. First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

    Zuojie Luo

  13. First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

    Guijun Qin

  14. Wuhan Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China

    Lulu Chen

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  1. Binqi Li
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Contributions

BL and JW contributed equally to this work and share first authorship. BL and JW contributed to the conception and design of the study. XZ, WW, ZG, XT, LY, QW, ZL, GQ, LC and GN recruited the subjects and supervised the study. BL analyzed the data and wrote the initial draft of the paper. YM, BL, and JW contributed to the writing, review, and revision of the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Yiming Mu.

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The authors declare no competing interests.

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The Committee on Human Research at Rui-Jin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University approved the study protocol. Informed consent was provided by all participants before data collection.

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Li, B., Wang, J., Zhou, X. et al. Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study. Hypertens Res 46, 708–719 (2023). https://doi.org/10.1038/s41440-022-01113-w

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