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Efficacy and safety of esaxerenone in patients with hypertension and concomitant heart failure

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References

  1. 1.

    Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Hypertens Res. 2019;42:1235–481.

    Article  Google Scholar 

  2. 2.

    Yang P, Shen W, Chen X, Zhu D, Xu X, Wu T, et al. Comparative efficacy and safety of mineralocorticoid receptor antagonists in heart failure: a network meta-analysis of randomized controlled trials. Heart Fail Rev. 2019;24:637–46.

    CAS  Article  Google Scholar 

  3. 3.

    Ito S, Itoh H, Rakugi H, Okuda Y, Yoshimura M, Yamakawa S. Double-blind randomized phase 3 study comparing esaxerenone (CS-3150) and eplerenone in patients with essential hypertension (ESAX-HTN study). Hypertension. 2020;75:51–58.

    CAS  Article  Google Scholar 

  4. 4.

    Tsutsui H, Isobe M, Ito H, Ito H, Okumura K, Ono M, et al. JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure—digest version. Circ J. 2019;83:2084–184.

    Article  Google Scholar 

  5. 5.

    Rakugi H, Ito S, Itoh H, Okuda Y, Yamakawa S. Long-term phase 3 study of esaxerenone as mono or combination therapy with other antihypertensive drugs in patients with essential hypertension. Hypertens Res. 2019;42:1932–41.

    CAS  Article  Google Scholar 

  6. 6.

    Lainscak M, Pelliccia F, Rosano G, Vitale C, Schiariti M, Greco C, et al. Safety profile of mineralocorticoid receptor antagonists: Spironolactone and eplerenone. Int J Cardiol. 2015;200:25–9.

    Article  Google Scholar 

  7. 7.

    Rossignol P, Dobre D, McMurray JJ, Swedberg K, Krum H, van Veldhuisen DJ, et al. Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). Circ Heart Fail. 2014;7:51–8.

    CAS  Article  Google Scholar 

  8. 8.

    Ferreira JP, Rossello X, Eschalier R, McMurray JJV, Pocock S, Girerd N, et al. MRAs in elderly HF patients: individual patient-data meta-analysis of RALES, EMPHASIS-HF, and TOPCAT. JACC Heart Fail. 2019;7:1012–21.

    Article  Google Scholar 

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Correspondence to Takashi Naruke.

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Naruke, T., Maemura, K., Oki, T. et al. Efficacy and safety of esaxerenone in patients with hypertension and concomitant heart failure. Hypertens Res 44, 601–603 (2021). https://doi.org/10.1038/s41440-020-00606-w

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Keywords

  • Antihypertensive drug
  • Mineralocorticoid receptor blocker
  • Plasma B-type natriuretic peptide

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