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Placental abruption in each hypertensive disorders of pregnancy phenotype: a retrospective cohort study using a national inpatient database in Japan

Abstract

We designed a retrospective cohort study using the Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan, to examine whether recent global diagnostic criteria for preeclampsia, phenotypes of hypertensive disorders of pregnancy (HDP) and features of the disease are useful as predictors of placental abruption and whether other risk factors are associated with the onset of placental abruption. A total of 85,858 hospitalized patients with a diagnosis of HDP who gave birth during hospitalization between July 2010 and March 2018 were included in this study. We examined the associations between the occurrence of placental abruption after hospitalization and several factors, including gestational age (GA) at placental abruption onset, HDP subtypes, GA on admission, maternal age, body mass index, smoking, multiple pregnancy, prelabor rupture of membranes, diabetes mellitus, emergency admission by ambulance, and consciousness, using a multivariate logistic regression analysis. Placental abruption occurred in 541 patients (0.63%) after hospital admission, and the occurrence increased acutely after 32 weeks GA. A decrease in abruption was significantly associated with maternal BMI on admission (≥30 kg/m2; odds ratio [OR], 0.54; 95% confidence interval [CI], 0.41–0.70) and multiple pregnancy (OR, 0.29; 95% CI, 0.18–0.46). An increase in abruption was associated with earlier GA on admission (<34 weeks’ GA; OR, 3.77; 95% CI, 3.13–4.53) and emergency admission by ambulance (OR, 1.34; 95% CI, 1.09–1.65). Individual features of severe PE showed no significant associations with the occurrence of abruption. In conclusion, HDP at an earlier GA was suggested to be a risk factor for placental abruption, and we recommend hospitalization and careful management of such patients to improve their prognosis.

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Acknowledgements

This work was supported by grants from the Ministry of Health, Labour and Welfare, Japan (19AA2007 and 20AA2005) and the Ministry of Education, Culture, Sports, Science and Technology, Japan (20H03907).

Members for the Advanced Life Support in Obstetrics (ALSO)-Japan Research Group

Ichiro Yasuhi6, Yasuhiko Ozaki7, Akiko Sakajo8, Atsushi Tajima9, Seiji Tsutsumi10, Satoru Nakayama11, Teruyuki Yamasaki12, Satoshi Nakago13, Yuji Hiramatsu14, Junko Mochizuki15, Mikio Hashiguchi16, Katsuhiko Naruse17, Takanari Arai18

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Correspondence to Katsuhiko Naruse.

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Members for the Advanced Life Support in Obstetrics (ALSO)-Japan Research Group are listed below Acknowledgements.

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Naruse, K., Shigemi, D., Hashiguchi, M. et al. Placental abruption in each hypertensive disorders of pregnancy phenotype: a retrospective cohort study using a national inpatient database in Japan. Hypertens Res 44, 232–238 (2021). https://doi.org/10.1038/s41440-020-00537-6

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Keywords

  • Chronic Hypertension
  • Gestational Hypertension
  • Japan
  • Placental Abruption
  • Preeclampsia

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