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Infographic: Intravitreal aflibercept injection in patients with myopic choroidal neovascularization: the MYRROR study

Eye (2023)Cite this article

Subjects

This study, conducted in East Asia, included patients aged 18 and over with visual impairment due to active choroidal neovascularization secondary to pathological myopia with spherical equivalence of ≥ −6D, or an axial length ≥26.5 mm. Activity of CNV lesions was confirmed on fluorescein angiography. Exclusion criteria included: one functional eye, recurrent myopic CNV, ocular inflammation, iris neovascularization, uncontrolled glaucoma or previous trabeculectomy. Predefined retreatment criteria for the aflibercept group (to a maximum frequency of 4-weekly) were: (1) loss of ≥5 ETDRS letters from previous visit (2) Increase in central retinal thickness ≥50 µm, or other OCT changes consistent with activity (3) investigator discretion. These criteria were applied to the control group from week 24 to 44. Note that the control group did not receive any intervention except for sham injections until week 24. The paper does not present statistical comparisons in adverse events between treatment groups.

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Funding

Medical Research Council UK (MR/R000735/1).

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Authors and Affiliations

  1. Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, Oxford University, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Imran H. Yusuf

  2. Oxford Eye Hospital, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford, OX3 9DU, UK

    Imran H. Yusuf

  3. UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK

    Christin Henein

  4. NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, UK

    Christin Henein & Sobha Sivaprasad

Authors
  1. Imran H. Yusuf
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  2. Christin Henein
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  3. Sobha Sivaprasad
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Corresponding author

Correspondence to Imran H. Yusuf.

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The authors declare no competing interests.

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Yusuf, I.H., Henein, C. & Sivaprasad, S. Infographic: Intravitreal aflibercept injection in patients with myopic choroidal neovascularization: the MYRROR study. Eye (2023). https://doi.org/10.1038/s41433-023-02393-3

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  • DOI: https://doi.org/10.1038/s41433-023-02393-3

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