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Non-contact widefield neonatal retinal imaging for retinopathy of prematurity using the Clarus 700 high resolution true colour reflectance imaging

Abstract

Objective

To illustrate the role of non-contact widefield retinal imaging (NC-WFI) of retinopathy of prematurity (ROP) using the Clarus 700 high resolution true colour reflectance imaging.

Methods

All babies were examined by the vitreoretinal faculty in a tertiary eye care centre from a period of March 2021 to November 2021 using the indirect ophthalmoscope after pupillary dilatation. ROP grading was done according to the revised ICROP (2005) classification. NC-WFI was then performed using the Clarus 700 high resolution true colour reflectance imaging (Carl Zeiss Meditec, Dublin, CA) in the retina diagnostic set up of a tertiary eye care centre.

Results

A total of 22 babies (44 eyes) underwent NC-WFI from March 2021 to November 2021. 13 unique cases of retinopathy of prematurity with images captured on Clarus 700 and the clinical summary is described.

Conclusion

Clarus is a non-contact wide field imaging (NC-WFI) system that can capture high resolution and true colour images (images of the fundus appear similar colour to direct observation by ophthalmoscopy) helping in more accurate diagnosis and grading of the severity of ROP.

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Fig. 1: Modified flying baby position.
Fig. 2: Non-contact widefield neonatal retinal imaging for retinopathy of prematurity using the Clarus 700 high resolution true colour reflectance imaging.
Fig. 3: Non-contact widefield neonatal retinal imaging for retinopathy of prematurity using the Clarus 700 high resolution true colour reflectance imaging.
Fig. 4: Non-contact widefield neonatal retinal imaging for retinopathy of prematurity using the Clarus 700 high resolution true colour reflectance imaging.
Fig. 5: Non-contact ultra widefield montage imaging for retinopathy of prematurity using the Clarus 700 high resolution true colour reflectance imaging.

Data availability

Data set is available with author AB and at ROP database office at LV Prasad Eye Institute, Hyderabad, Telangana, India-500034.

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Funding

Hyderabad Eye Research Foundation (2020), Hyderabad, India. The institute has received funding or support for its ongoing Retinopathy of Prematurity programs from Miriam Hyman Memorial Trust (MHMT, UK), Dalmia Holdings (India), Queen Elizabeth Diamond Jubilee Trust (UK), Public Health Foundation of India, Cognizant Foundation and the Government of India. Grant number LEC 08088.

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Authors and Affiliations

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Contributions

AB and SJ: Devised and designed the study, devised data collection protocol and data analysis, Literature search, wrote the Manuscript. RUR: Captured the images on Clarus. KA, DCP: Helped in Data collection, improving content and editing the manuscript.

Corresponding author

Correspondence to Subhadra Jalali.

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The authors declare no competing interests.

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Belenje, A., Reddy, R.U., Optom, B. et al. Non-contact widefield neonatal retinal imaging for retinopathy of prematurity using the Clarus 700 high resolution true colour reflectance imaging. Eye (2022). https://doi.org/10.1038/s41433-022-02273-2

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