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Genomics and personalized strategies in nutrition

Genetically predicted coffee and tea consumption and risk of intracranial aneurysm

European Journal of Clinical Nutrition volume 77, pages 811–814 (2023)Cite this article

Subjects

Abstract

Objectives

Observational studies have shown associations between coffee and tea consumption and risk of intracranial aneurysm (IA). However, the results are not consistent. We conducted a Mendelian randomization study to clarify whether genetically predicted coffee and tea consumption has a causal effect on IA and its subtypes.

Methods

Genetic variants associated with coffee and tea consumption (cups/day) were obtained from large genome-wide association studies (GWASs), up to 349,376 subjects. Summary-level data for IA were adopted from a GWAS in 79,429 subjects (23 cohorts, 7495 cases, and 71,934 controls).

Results

Genetically predicted coffee consumption was associated with a higher risk of any IA and aneurysmal subarachnoid hemorrhage (SAH), but not with unruptured IA. The ORs per 1 cup/day increase in genetically predicted coffee consumption were 1.42 (95% CI: 1.09–1.86; P = 0.010) for IA, 1.51 (95% CI: 1.13–2.03; P = 0.005) for aneurysmal SAH, and 1.20 (95% CI: 0.74–1.96; P = 0.460) for unruptured IA. Genetically predicted tea consumption was not associated with risk of any IA and its subtypes (P > 0.05). The associations remained consistent in sensitivity analyses, and no evidence of pleiotropy was detected.

Conclusions

Our study provides evidence to support that coffee consumption may increase the risk of IA and associated hemorrhage. Coffee should be limited for those at high risk of IA and associated hemorrhage.

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Fig. 1: Study design and data sources used in the present study.
Fig. 2: Association of genetically predicted coffee consumption with intracranial aneurysm.
Fig. 3: Association of genetically predicted coffee consumption with aneurysmal subarachnoid hemorrhage.

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Data availability

The data that supports the findings of this study are available in Supplementary Table 1.

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Acknowledgements

We thank the International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm working group and UK Biobank. Summary information for intracranial aneurysms was obtained from the ISGC Cerebrovascular Disease Knowledge Portal.

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Authors and Affiliations

  1. Department of Neurology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China

    Zhizhong Zhang & Xinfeng Liu

  2. Department of Neurology, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Mengmeng Wang

  3. Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Shuai Yuan & Susanna C. Larsson

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  1. Zhizhong Zhang
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  2. Mengmeng Wang
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Contributions

Z.Z. and X.L. designed the research, performed the statistical analysis, and drafted the paper. MW, SY, and SCL interpreted the data and made critical revisions of the paper.

Corresponding author

Correspondence to Xinfeng Liu.

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Competing interests

The authors declare no competing interests.

Ethical approval

Our analyses used publicly available genome-wide association study summary data. Each study included in this study had already obtained related ethical review board approvals, and all participants provided informed consent.

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Zhang, Z., Wang, M., Yuan, S. et al. Genetically predicted coffee and tea consumption and risk of intracranial aneurysm. Eur J Clin Nutr 77, 811–814 (2023). https://doi.org/10.1038/s41430-023-01295-7

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