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Nutrigenomics and molecular nutrition

The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India

European Journal of Clinical Nutrition volume 74, pages 604–612 (2020)Cite this article

Subjects

Abstract

Objective

The aim of the present study was to evaluate polymorphisms of fat mass and obesity (FTO; rs9939609) and vitamin D receptor (VDR, FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236)] genes on weight loss after lifestyle interventions in Asian Indians.

Methods

In this 6-month pre–post intervention trial, 110 overweight/obese men and women underwent diet and exercise interventions for 180 days resulting in reduction in body weight, (5.1 kg, p < 0.001), waist circumference, and skinfolds.

Results

Association of the following genotypes was seen in those with ≥5% weight loss: TT of FTO polymorphism; 35 (81.4%) [OR (95% CI) AT, 2.5 (0.6, 10.9); TT, 6.9 (1.6, 28.2); with reference to AA], tt of VDR TaqI polymorphism, 12 (92.3%) [OR (95% CI); tt, 32.2 (2.4, 436.4); TT, 0.5 (0.08, 3.1); all with reference to Tt], bb of VDR BsmI polymorphism; 27 (65.8%) [OR (95% CI) Bb, 0.2 (0.04, 0.9); bb, 10.6 (0.9, 120.3); all with reference to BB] after adjusting for other genotypes. Further, analysis of combined influence of genotypes conferring maximum weight loss showed that the following had high odds of ≥5% weight loss: (1) TT of FTO gene in combination with BB/Bb of VDR BsmI and TT/Tt of VDR TaqI [OR (95% CI) 5.1 (1.5, 17.4)], (2) bb of BsmI and AA/AT of FTO and tt of TaqI [OR (95% CI) 3.2 (0.3, 31.7)], and (3) bb of BsmI plus TT of FTO and tt of TaqI.

Conclusions

The above observations suggest a significant and independent role of the genotypes of FTO and VDR in influencing weight loss after lifestyle intervention in Asian Indians.

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Acknowledgements

Authors are thankful to Dr Kalpana Luthra for critically reviewing the manuscript.

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Authors and Affiliations

  1. Diabetes Foundation, New Delhi, India

    Seema Gulati & Anoop Misra

  2. National Diabetes, Obesity and Cholesterol Foundation (N-DOC), New Delhi, India

    Seema Gulati, Anoop Misra, Rajneesh Tiwari & Meenu Sharma

  3. Center of Nutrition & Metabolic Research (C-NET), New Delhi, India

    Seema Gulati & Anoop Misra

  4. Fortis C-DOC Center for Excellence for Diabetes, Metabolic Disease and Endocrinology, New Delhi, India

    Anoop Misra

  5. All India Institute of Medical Sciences, New Delhi, India

    Ravindra M. Pandey & Ashish Datt Upadhyay

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SG researched data, wrote manuscript, conducted the study, AM wrote manuscript, contributed to discussion, reviewed/edited manuscript, RMP and ADU performed statistical analysis RT and MS contributed to data collection and conduct of the study.

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Correspondence to Anoop Misra.

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Gulati, S., Misra, A., Tiwari, R. et al. The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India. Eur J Clin Nutr 74, 604–612 (2020). https://doi.org/10.1038/s41430-020-0560-4

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