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Lipids and cardiovascular/metabolic health

Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial

European Journal of Clinical Nutrition volume 73, pages 1403–1411 (2019)Cite this article

Subjects

Abstract

Objectives

Metabolic syndrome (MetS) represents a clustering of metabolic abnormalities that are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to evaluate the effects of sesame oil enriched with vitamin E (vit E), sesame oil alone and sunflower oil on lipid profile, fasting blood glucose (FBG), malondialdehyde (MDA), high-sensitivity C-reactive protein (Hs-CRP), homeostatic model assessment (HOMA-IR), and blood pressure (BP) in patients with MetS.

Subjects

Overall, 75 individuals with MetS (aged 30–70 years) participated in this randomized, single-blind controlled trial. Patients were randomly allocated to: (1) Group A (n = 25): sesame oil (30 ml/day) enriched with vit E (400 mg/day), (2) Group B (n = 25): sesame oil (30 ml/day), (3) Group C (n = 25): sunflower oil (30 ml/day). Anthropometric data, dietary intake, blood pressure, and biochemical markers, including fasting serum lipids, FBG, serum insulin, MDA, and hs-CRP were measured at baseline and at week 8.

Results

In individuals in the sesame oil enriched with vit E group (Group A), there were significant reductions in serum total cholesterol (TC), triglycerides (TG), FBG, HOMA-IR, MDA, hs-CRP, high-density lipoprotein (HDL-C) systolic and diastolic BP (for all the comparison p < 0.02). Similarly, in Group B (taking sesame oil alone), TC, TG, FBG, HOMA-IR, MDA, systolic and diastolic BP were significantly improved (for all the comparison p < 0.025), while there were no significant changes in serum HDL (baseline = 35.9 ± 7.2 mg/dL vs. 36.4 ± 6.2 mg/dL, p = 0.432) and hs-CRP (baseline = 4.38 ± 1.34 mg/dL vs. week 8 = 3.96 ± 1.7 mg/dL, p = 0.057) in second group. No significant changes in any of the studied clinical and anthropometric data were found in Group C (on sunflower oil).

Conclusion

Sesame oil (±vit E) was shown to beneficially affect several cardiometabolic indices (including lipids, FBG, BP, HOMA-IR, and MDA) in patients with MetS.

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Funding

This study was supported by the Shiraz University of Medical Sciences, Shiraz, Iran.

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Authors and Affiliations

  1. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

    Ali Farajbakhsh, Marzieh Akbarzadeh, Saeedeh Poor Ahmad & Siavash Babajafari

  2. Department of Food Hygiene and Quality Control, School and Research Center of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Mohammad Mazloomi

  3. Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, SE-41296, Gothenburg, Sweden

    Mohsen Mazidi

  4. Adelaide Medical School, University of Adelaide, Adelaide, Australia

    Peyman Rezaie

  5. Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK

    G. A. Ferns

  6. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

    Richard Ofori-Asenso

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Farajbakhsh, A., Mazloomi, S.M., Mazidi, M. et al. Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial. Eur J Clin Nutr 73, 1403–1411 (2019). https://doi.org/10.1038/s41430-019-0438-5

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