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Body composition, energy expenditure and physical activity

Serum advanced glycation end products are not associated with muscle strength in hemodialysis patients

European Journal of Clinical Nutrition volume 73, pages 617–623 (2019)Cite this article

Subjects

Abstract

Background

Advanced glycation end products (AGEs) are elevated in patients with renal failure and may potentially affect skeletal muscle. The aim of this study was to evaluate whether serum concentrations of AGEs are associated with muscle strength in hemodialysis (HD) patients, since this association is not clear in the literature.

Methods

This research has a cross-sectional design and included 96 patients on hemodialysis treatment (20–69 years). Serum AGEs (ELISA), three-day dietary records, anthropometric and bioimpedance variables and handgrip strength (HGS) were analysed. Serum AGEs were analyzed by ELISA test.

Results

Men’s HGS were significantly higher than women’s (p < 0.001). Serum AGEs of the individuals of the highest HGS quartile versus the lowest quartile were 11.27 ± 2.52 and 9.06 ± 2.14 (µg/mL), respectively (p = 0.02). After adjustment for potential confounders, the correlation between serum AGEs and HGS lost statistical significance. The main factors that were associated to muscle strength were aging, BMI, percentage of fat-free mass and serum albumin.

Conclusion

Contrary to our hypothesis, serum AGEs were not associated with muscular strength in HD patients. These results suggest that serum AGE is not a good indicator of muscle strength in this population and others factors related to the disease may be more important and significant in reducing muscle strength than the serum concentrations of AGEs alone.

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Acknowledgements

The authors would like to thank the Coordenação de Aperfeiçoamento de Nível Superior (CAPES) for the scholarship and Rodrigo Tallada Iborra (Laboratório de Lipides (LIM 10), Hospital das Clinicas (HCFMUSP) da Faculdade de Medicina da Universidade de Sao Paulo, BR) for measuring serum AGEs. MP received a grant from Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Authors and Affiliations

  1. Graduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goias, Goiania, Brazil

    Debora M. Silva, Nayara P. Queiroz, Ana Tereza V. S. Freitas & Maria do Rosário G. Peixoto

  2. Laboratório de Lipides (LIM 10), Hospital das Clinicas (HCFMUSP) da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, SP, Brazil

    Marisa Passarelli

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  1. Debora M. Silva
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Correspondence to Maria do Rosário G. Peixoto.

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Silva, D.M., Queiroz, N.P., Freitas, A.T.V.S. et al. Serum advanced glycation end products are not associated with muscle strength in hemodialysis patients. Eur J Clin Nutr 73, 617–623 (2019). https://doi.org/10.1038/s41430-018-0379-4

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