Crystal Ball series

From fat cells through an obesity theory

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Sørensen TIA. Challenges in the study of causation of obesity. Proc Nutr Soc. 2009;68:43–54.

    Article  Google Scholar 

  2. 2.

    Dhurandhar N, Schoeller D, Brown A, Heymsfield S, Thomas D, Sørensen TIA, et al. Energy balance measurement: when something is not better than nothing. Int J Obes. 2015;39:1109–13.

    CAS  Article  Google Scholar 

  3. 3.

    Sørensen TIA, Virtue S, Vidal-Puig A. Obesity as a clinical and public health problem: Is there a need for a new definition based on lipotoxicity effects? Biochim Biophys Acta. 2010;1801:400–04.

    Article  Google Scholar 

  4. 4.

    The Danish Obesity Project. Randomised trial of of jejunoileal bypass versus medical treatment in morbid obesity. Lancet. 1979;2:1255–8.

  5. 5.

    Sørensen TIA. Jejunum and bile acid synthesis–comparison of effects of jejunoileal bypass with 3:1 and 1:3 jejunoileal ratio [Doctoral Thesis]. Scand J Gastroenterol. 1982;17:577–86.

    Article  Google Scholar 

  6. 6.

    Christensen GT, Molbo D, Ängquist LH, Mortensen EL, Christensen K, Sørensen TIA, et al. Cohort profile: The Danish Conscription Database (DCD). A cohort of 727 829 men born from 1939 through 1959. Int J Epidemiol. 2015;44:432–40.

    Article  Google Scholar 

  7. 7.

    Sørensen TIA, Sonne-Holm S. Mortality in extremely overweight young men. J Chronic Dis. 1977;30:359–67.

    Article  Google Scholar 

  8. 8.

    Zimmermann E, Holst C, Sørensen TIA. Morbidity, including fatal morbidity throughout life, in men entering adult life as obese. PLoS ONE. 2011;6:e18546.

    CAS  Article  Google Scholar 

  9. 9.

    Berentzen T, Sørensen TIA. Effects of intended weight loss on morbidity and mortality: possible explanations of controversial results. Nutr Rev. 2006;64:502–07.

    Article  Google Scholar 

  10. 10.

    Graf CE, Herrmann FR, Spoerri A, Makhlouf A-M, Sørensen TIA, Ho S, et al. Impact of body composition changes and risk of all-cause mortality in persons 65 years old and above. Clin Nutr. 2016;35:1466–1505.

    Article  Google Scholar 

  11. 11.

    Sonne-Holm S, Sørensen TIA. Post-war course of the prevalence of extreme overweight among Danish young men. J Chronic Dis. 1977;30:351–58.

    CAS  Article  Google Scholar 

  12. 12.

    Christensen U, Sonne-Holm S, Sørensen TIA. Constant median body mass index of Danish young men, 1943–1977. Hum Biol. 1981;53:403–10.

    CAS  PubMed  Google Scholar 

  13. 13.

    Rokholm B, Baker JL, Sørensen TIA. The levelling off of the obesity epidemic since the year 1999–a review of evidence and perspectives. Obes Rev. 2010;11:835–46.

    CAS  Article  Google Scholar 

  14. 14.

    Baker JL, Olsen LW, Andersen I, Pearson S, Hansen B, Sørensen TIA. Cohort profile: The Copenhagen School Health Records Register. Int J Epidemiol. 2009;38:656–62.

    Article  Google Scholar 

  15. 15.

    Olsen LW, Baker JL, Holst C, Sørensen TIA. Birth cohort effect on the obesity epidemic in Denmark. Epidemiology. 2006;17:292–95.

    Article  Google Scholar 

  16. 16.

    Petersen L, Sørensen TIA. The Danish Adoption Register. Scand J Public Health. 2011;39:83–6.

    Article  Google Scholar 

  17. 17.

    Petersen L, Sørensen TIA. Studies based on the Danish Adoption Register. Scand J Public Health. 2011;39:191–5.

    Article  Google Scholar 

  18. 18.

    Sørensen TIA, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influence on premature death of adult adoptees. N Engl J Med. 1988;318:727–32.

    Article  Google Scholar 

  19. 19.

    Stunkard AJ, Sørensen TIA, Hanis C, Teasdale TW, Chakraborty R, Schull WJ, et al. An adoption study of human obesity. N Engl J Med. 1986;314:193–8.

    CAS  Article  Google Scholar 

  20. 20.

    Sørensen TIA, Price RA, Stunkard AJ, Schulsinger F. Genetics of obesity in adult adoptees and their biological siblings. Br Med J. 1989;298:87–90.

    Article  Google Scholar 

  21. 21.

    Vogler GP, Sørensen TIA, Stunkard AJ, Srinivasan MR, Rao DC. Influences of genes and shared family environment on adult body mass index assessed in an adoption study by a comprehensive path model. Int J Obes. 1995;19:40–5.

    CAS  Google Scholar 

  22. 22.

    Sørensen TIA, Holst C, Stunkard AJ. Childhood body mass index - genetic and familial environmental influences assessed in a longitudinal study. Int J Obes. 1992;16:705–14.

    Google Scholar 

  23. 23.

    Silventoinen K, Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Honda C, et al. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the CODATwins study. Am J Clin Nutr. 2016;104:371–79.

    CAS  Article  Google Scholar 

  24. 24.

    Ajslev TA, Ängquist L, Silventoinen K, Baker JL, Sørensen TIA. Stable intergenerational associations of childhood overweight during the development of the. Obes Epidemic Obes. 2015;23:1279–87.

    Google Scholar 

  25. 25.

    Sørensen TIA, Sonne-Holm S, Christensen U. Reduced intellectual performance in extreme overweight. Hum Biol. 1982;54:765–75.

    PubMed  Google Scholar 

  26. 26.

    Sørensen TIA, Sonne-Holm S. Intelligence test performance in obesity in relation to educational attainment and parental social class. J Biosoc Sci. 1985;17:379–87.

    Article  Google Scholar 

  27. 27.

    Goldblatt PB, Moore ME, Stunkard AJ. Social factors in obesity. J Am Med Assoc. 1965;192:1039–44.

    CAS  Article  Google Scholar 

  28. 28.

    Sonne-Holm S, Sørensen TIA. Prospective study of attainment of social class of severely obese subjects in relation to parental social class, intelligence, and education. Br Med J. 1986;292:586–9.

    CAS  Article  Google Scholar 

  29. 29.

    Stunkard AJ, Sørensen TIA. Obesity and socioeconomic status—a complex relation. N Engl J Med. 1993;329:1036–7.

    CAS  Article  Google Scholar 

  30. 30.

    Teasdale TW, Sørensen TIA, Stunkard AJ. Genetic and early environmental components in sociodemographic influences on adult body fatness. Br Med J. 1990;300:1615–8.

    CAS  Article  Google Scholar 

  31. 31.

    Fontaine KR, Robertson HT, Holst C, Desmond R, Stunkard AJ, Sørensen TIA, Allison DB. Is socioeconomic status of the rearing environment causally related to obesity in the offspring? PLoS ONE. 2011;6:e27692.

    CAS  Article  Google Scholar 

  32. 32.

    Morgen CS, Ängquist L, Baker JL, Andersen A-MN, Michaelsen KF, Sørensen TIA. Prenatal risk factors influencing childhood BMI and overweight independent of birth weight and infancy BMI–a path analysis within the Danish National Birth Cohort. Int J Obes. 2017. https://doi.org/10.1038/ijo.2017.217.

    Article  Google Scholar 

  33. 33.

    Lissau-Lund-Sørensen I, Sørensen TIA. Prospective study of the influence of social factors in childhood on risk of overweight in adulthood. Int J Obes. 1992;16:169–75.

    Google Scholar 

  34. 34.

    Lissau I, Sørensen TIA. Parental neglect during childhood and increased risk of obesity in young adulthood. Lancet. 1994;343:324–7.

    CAS  Article  Google Scholar 

  35. 35.

    Li J, Olsen J, Vestergaard M, Obel C, Baker JL, Sørensen TIA. Prenatal stress exposure related to maternal bereavement and risk of childhood overweight. PLoS ONE. 2010;5:e11896.

    Article  Google Scholar 

  36. 36.

    Li J, Olsen J, Vestergaard M, Obel C, Baker JL, Sørensen TIA. Bereavement in early life and later childhood overweight. Obes Facts. 2012;5:881–9.

    Article  Google Scholar 

  37. 37.

    Hohwü L, Li J, Olsen J, Sørensen TIA, Obel C. Severe maternal stress exposure dure to bereavement before, during and after pregnancy and risk of overweight and obesity in young adult men: a Danish National Cohort Study. PLoS ONE. 2014;9:e97490.

    Article  Google Scholar 

  38. 38.

    Ingstrup KG, Andersen CS, Ajslev TA, Pedersen P, Sørensen TIA, Nøhr EÅ. Maternal distress during pregnancy and childhood overweight. J Obes. 2012;2012:e462845.

    Article  Google Scholar 

  39. 39.

    Ajslev TA, Andersen CS, Ingstrup KG, Nohr EA, Sørensen TIA. Maternal postpartum distress and childhood overweight. PLoS ONE. 2010;5:e11136.

    Article  Google Scholar 

  40. 40.

    Richmond R, Timpson N, Sørensen TIA. Exploring possible epigenetic mediation of early life environmental exposures on adiposity and obesity development. Int J Epidemiol. 2015;44:1191–98.

    Article  Google Scholar 

  41. 41.

    Nettle D, Andrews C, Bateson M. Food insecurity as a driver of obesity in humans: the insurance hypothesis. Behav Brain Sci. 2016;40:e105.

    Article  Google Scholar 

  42. 42.

    Kaiser KA, Smith DL, Allison DB. Conjectures on some curious connections among social status, calorie restriction, hunger, fatness, and longevity. Ann NY Acad Sci. 2012;1264:1–12.

    Article  Google Scholar 

  43. 43.

    Sørensen TIA. Challenges in understanding development of obesity [Book Chapter 1]. In: Nobrega C, Rodriguez-Lopez R, editors. Molecular mechanisms underpinning the development of obesity. Springer International Publishing Switzerland; 2014. pp. 1–9.

  44. 44.

    Johnson W, Kyvik KO, Skytthe A, Deary IJ, Sørensen TI. Education modifies genetic and environmental influences on BMI. PLoS ONE. 2011;6:e16290.

    CAS  Article  Google Scholar 

  45. 45.

    Locke AE, Kahali B, Berndt SI, Justrice AE, Pers TH, Day FR, Powel C, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518:197–206.

    CAS  Article  Google Scholar 

  46. 46.

    Bullik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh PR, et al. An atlas of genetic correlations across human diseases and traits. Nat Genet. 2015;47:1236–41.

    Article  Google Scholar 

  47. 47.

    NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body mass index in 200 countries from 1975 to 2014: a pooled analysis of 1,698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387:1377–96.

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Thorkild I. A. Sørensen.

Ethics declarations

Conflict of interest

The author declares that he has no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sørensen, T.I.A. From fat cells through an obesity theory. Eur J Clin Nutr 72, 1329–1335 (2018). https://doi.org/10.1038/s41430-018-0100-7

Download citation

Further reading

Search

Quick links