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Penicixanthene E, a new xanthene isolated from a mangrove-derived fungus Penicillium sp.

The Journal of Antibiotics volume 75, pages 526–529 (2022)Cite this article

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Abstract

One new xanthene derivative, named penicixanthene E (1), together with one known compound 2, was isolated from the EtOAc extract of the endophytic fungus Penicillium sp. GXIMD 03101, which was identified from the mangrove Acanthus ilicifolius L. collected in the South China Sea. The structure of 1 was elucidated by 1D and 2D NMR spectral interpretation and HREISMS data. The absolute configurations of C-9 and C-11 in 1 were proposed based on electronic circular dichroism (ECD), but the configuration at C-3 in 1 was unassigned. Compound 1 represents a xanthene derivative that was first reported, in which carbon-carbon double bond has been reduced. The cytotoxic activities of all compounds were evaluated, the result showed that compound 1 has weak activity against pancreatic cancer SW1990.

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Acknowledgements

This work was supported by the Natural Science Foundation of Guangxi (No. 2021GXNSFBA220072, 2020GXNSFAA297106, 2020GXNSFGA297002); the Initial Scientific Research Foundation of Introduced Doctors in 2020 of Guangxi University of Chinese Medicine (No. 2020BS024, 2018BS038); Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (No. 2021004); Regional Innovation and Development Joint Fund of National Natural Science Foundation of China (No. U20A20101); Guangxi University of Chinese Medicine “GuiPai Traditional Chinese Medicine inheritance and innovation team” Project (No. 2022A007); the Special Fund for Bagui Scholars of Guangxi (No. 05019055).

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  1. Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, 530200, PR China

    Guang-Ping Cao, Jia-Lang Xia, Long-Yan Zhao, Zhen-Zhou Tang, Xiao Lin, Yong-Hong Liu, Cheng-Hai Gao, Kai Liu & Meng Bai

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Cao, GP., Xia, JL., Zhao, LY. et al. Penicixanthene E, a new xanthene isolated from a mangrove-derived fungus Penicillium sp.. J Antibiot 75, 526–529 (2022). https://doi.org/10.1038/s41429-022-00548-0

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