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A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain

The Journal of Antibiotics volume 75, pages 491–497 (2022)Cite this article

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Abstract

A novel vicinal diepoxide of alloaureothin was isolated from Streptomyces sp. NIIST-D31 strain along with three carboxamides, p-aminobenzoic acid and 1,6-dimethoxyphenazine. Exhaustive 2D NMR analysis and analysis of experimental, theoretical CD spectra aided in establishing the structure of compound 1. Compound 1 inhibits adipogenesis and accumulation of lipid droplets during the differentiation of 3T3-L1 cells.

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Acknowledgements

Financial support from DST, Science, and Engineering Research Board, India (Grant number: CRG/2020/004993) is gratefully acknowledged. TD, DKI, MSP, and ARSJ are grateful to UGC and CSIR for senior research fellowship.

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Authors and Affiliations

  1. Agro-Processing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, Kerala, India

    Thankappan Drissya, M. S. Poornima, A. R. S. Jesmina, K. G. Raghu & B. S. Dileep Kumar

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

    Thankappan Drissya, D. K. Induja, M. S. Poornima, A. R. S. Jesmina, Mathew Saumini, Cherumuttathu H. Suresh, K. G. Raghu, B. S. Dileep Kumar & Ravi S. Lankalapalli

  3. Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, Kerala, India

    D. K. Induja, Bernard Prabha, Mathew Saumini, Cherumuttathu H. Suresh & Ravi S. Lankalapalli

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  1. Thankappan Drissya
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Correspondence to Ravi S. Lankalapalli.

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Drissya, T., Induja, D.K., Poornima, M.S. et al. A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain. J Antibiot 75, 491–497 (2022). https://doi.org/10.1038/s41429-022-00547-1

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