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1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones with antibacterial activities from soil-derived Streptomyces sp. WS-13394


Two new 1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones (12) were isolated from the culture broth of the soil actinomycete Streptomyces sp. WS-13394. Their structures were elucidated on the basis of extensive spectroscopic analysis, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD). Compounds 1 and 2, together with eight analogs (310), were evaluated for their antibacterial activities against five pathogens. The tested derivatives of alkylated anthraquinone exhibited selective activities to Gram-positive bacteria, while compounds 1 and 5 showed obvious activities against two zoonotic pathogens, Erysipelothrix rhusiopathiae and Streptococcus suis, with MIC values ranging from 3.13 to 12.5 µg ml−1.

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This research was financially supported by Natural Science Foundation of Hubei Province, China (2021CFB070) and Hubei Agricultural Science and Technology Innovation Center (2019-620-000-001-027).

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Correspondence to Wei Fang.

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Wu, Z., Liu, M., Li, K. et al. 1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones with antibacterial activities from soil-derived Streptomyces sp. WS-13394. J Antibiot 75, 375–379 (2022).

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