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Hygromycin A derivatives isolated from Streptomyces sp. PC-22 in the rhizosphere soil of Pulsatilla chinensis

The Journal of Antibiotics volume 75, pages 176–180 (2022)Cite this article

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Abstract

On the basis of the one strain-many compounds (OSMAC) strategy, two new hygromycin A derivatives (3, 4), together with six known compounds were isolated from a medicinal plant inter rhizospheric Streptomyces in Pulsatilla chinensis. The structures of 3 and 4 were elucidated using NMR and HRESIMS analyses. A plausible biosynthetic pathway for these compounds was discussed. All the compounds were evaluated for their antimicrobial and cytotoxic activities. Compound 5 exhibited potent inhibitory activity against S. aureus and B. subtilis with the MICs of 16 and 8 μg ml−1, while 4 showed weak inhibitory activity against S. aureus.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation (81803391), the Natural Science Foundation of Jiangsu (BK20180828), Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province (ARRLKF21-01), Jiangsu Provincial “Double Creation Talent Program” (202010528) and the Natural Science Foundation Youth Program of Nanjing University of Chinese Medicine (NZY81803391).

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Authors and Affiliations

  1. Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China

    Xiaoqian Ding, Tianjie Yuan, Xiachang Wang, Xiao Liu, Yang Hu & Lihong Hu

  2. Jiangsu Province Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, 210029, People’s Republic of China

    Weiwei Chen

  3. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, 610052, People’s Republic of China

    Yiwen Chu & Yang Hu

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  1. Xiaoqian Ding
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Correspondence to Xiao Liu, Yang Hu or Lihong Hu.

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Ding, X., Yuan, T., Chen, W. et al. Hygromycin A derivatives isolated from Streptomyces sp. PC-22 in the rhizosphere soil of Pulsatilla chinensis. J Antibiot 75, 176–180 (2022). https://doi.org/10.1038/s41429-022-00506-w

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