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Rausuquinone, a non-glycosylated pluramycin-class antibiotic from Rhodococcus

The Journal of Antibiotics volume 75, pages 86–91 (2022)Cite this article

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Abstract

A new pluramycin-class polyketide, rausuquinone (1), and its known congener hydramycin (2) were isolated from the culture extract of the deep-sea water-derived Rhodococcus sp. RD015140. Compound 1 possesses a γ-pyrone-fused anthraquinone core with a 3-butene-1,2-diol side chain. Structures of 1 was determined by extensive analysis of 1D and 2D NMR spectroscopic data. Compound 1 showed antimicrobial activity against Gram-positive bacteria. This is the first discovery of aromatic polyketides from the genus Rhodococcus.

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Acknowledgements

This work was partially supported by the Japan Society for the Promotion of Science (JSPS) for Young Scientists (21K14794).

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  1. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan

    Enjuro Harunari, Maho Bando & Yasuhiro Igarashi

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  1. Enjuro Harunari
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  2. Maho Bando
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  3. Yasuhiro Igarashi
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Correspondence to Yasuhiro Igarashi.

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Harunari, E., Bando, M. & Igarashi, Y. Rausuquinone, a non-glycosylated pluramycin-class antibiotic from Rhodococcus. J Antibiot 75, 86–91 (2022). https://doi.org/10.1038/s41429-021-00489-0

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