A novel compound (1) and three known ones (2−4) were isolated from the fruiting bodies of Pleurocybella porrigens. The structure of the novel compound was determined by 1D and 2D NMR and HRESIMS data. The biological activity of 1−3 was evaluated using the A549 lung cancer cell line. The results showed the inhibitory activity of compounds 1−3 on the expression of Axl and immune checkpoint molecules.
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This research was funded by a Grant-in Aid for Scientific Research on Innovative Areas “Frontier Research on Chemical Communications” from MEXT (No 17H06402) and Specific Research Grant from Takeda Science Foundation.
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Ridwan, A.Y., Wu, J., Harada, E. et al. Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens. J Antibiot 73, 733–736 (2020). https://doi.org/10.1038/s41429-020-0323-4