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Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens


A novel compound (1) and three known ones (24) were isolated from the fruiting bodies of Pleurocybella porrigens. The structure of the novel compound was determined by 1D and 2D NMR and HRESIMS data. The biological activity of 13 was evaluated using the A549 lung cancer cell line. The results showed the inhibitory activity of compounds 13 on the expression of Axl and immune checkpoint molecules.

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This research was funded by a Grant-in Aid for Scientific Research on Innovative Areas “Frontier Research on Chemical Communications” from MEXT (No 17H06402) and Specific Research Grant from Takeda Science Foundation.

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Correspondence to Hirokazu Kawagishi.

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Ridwan, A.Y., Wu, J., Harada, E. et al. Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens. J Antibiot 73, 733–736 (2020).

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