Curvulaide A (1), a new bicyclic polyketide, together with its known congener preussilide D, were produced by solid-state fermentation with Curvularia sp. IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data, high resolution electrospray ionization mass spectrometry (HRESIMS), experimental and calculated electronic circular dichroism (ECD) spectra. Curvulaide A (1) exhibited moderate anti-anaerobic bacteria activity against periodontal pathogen Porphyromonas gingivalis with the MIC value of 62.5 μM, and showed moderate cytotoxicity against human hepatoma cell lines BEL7402/5-Fu with IC50 values of 12.46 μM.
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This work was financially supported by the NSFC grants (81703388, 81741156), the Shanghai Sailing Program (17YF1403700), the Fundamental Research Funds for the Central Universities (222201714023, 22221818014), and Talent Program of School of Biotechnology in East China University of Science and Technology.
Conflict of interest
The authors declare that they have no conflict of interest.