Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp.


Curvulaide A (1), a new bicyclic polyketide, together with its known congener preussilide D, were produced by solid-state fermentation with Curvularia sp. IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data, high resolution electrospray ionization mass spectrometry (HRESIMS), experimental and calculated electronic circular dichroism (ECD) spectra. Curvulaide A (1) exhibited moderate anti-anaerobic bacteria activity against periodontal pathogen Porphyromonas gingivalis with the MIC value of 62.5 μM, and showed moderate cytotoxicity against human hepatoma cell lines BEL7402/5-Fu with IC50 values of 12.46 μM.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1
Fig. 2
Fig. 3


  1. 1.

    Minotti G, et al. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004;56:185–229.

  2. 2.

    Blunt JW, et al. Marine natural products. Nat Prod Rep. 2018;34:235–94.

  3. 3.

    Noumeur SR, et al. Preussilides A-F, bicyclic polyketides from the endophytic fungus Preussia similis with antiproliferative activity. J Nat Prod. 2017;80:1531–40.

  4. 4.

    Shiono Y, et al. Antarones A and B, two polyketides from an endophytic Penicillium antarcticum. Z Nat. 2008;63b:909–14.

  5. 5.

    Jung HJ, et al. Embellistatin, a microtubule polymerization inhibitor, inhibits angiogenesis both in vitro and in vivo. Biochem Biophys Res Commun. 2007;353:376–80.

  6. 6.

    Breinholt J, et al. Hamigerone and dihydrohamigerone: two acetate-derived, antifungal metaboltes from Hamigera avellanea. Acta Chem Scand. 1997;51:1241-4.

  7. 7.

    Han WB, et al. Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species. Org Lett. 2014;16:5366–9.

  8. 8.

    Han WB, et al. Curindolizine, an anti-inflammatory agent assembled via Michael addition of pyrrole alkaloids inside fungal cells. Org Lett. 2016;18:1816–9.

  9. 9.

    Dong JW, et al. Production of a new tetracyclic triterpene sulfate metabolite sambacide by solid-state cultivated Fusarium sambucinum B10.2 using potato as substrate. Bioresour Technol. 2016;218:1266–70.

  10. 10.

    Pescitelli G, Di BL. Revision of the absolute configuration of preussilides A–F established by the exciton chirality method. J Nat Prod. 2017;80:2855–9.

  11. 11.

    Zhang Y, et al. Antibacterial and antibiofilm activities of eugenol from essential oil of Syzygium aromaticum (L.) Merr. & L. M. Perry (clove) leaf against periodontal pathogen Porphyromonas gingivalis. Microb Pathog. 2017;113:396–402.

  12. 12.

    Huang HY, et al. Reversal effect of 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone on multi-drug resistance in resistant human hepatocellular carcinoma cell line BEL-7402/5-FU. Phytomedicine. 2011;18:1086–92.

  13. 13.

    Reed LJ. A simple method estimating fifty percent endpoint. Am J Epidemiol. 1938;27:493–7.

Download references


This work was financially supported by the NSFC grants (81703388, 81741156), the Shanghai Sailing Program (17YF1403700), the Fundamental Research Funds for the Central Universities (222201714023, 22221818014), and Talent Program of School of Biotechnology in East China University of Science and Technology.

Author information

Correspondence to Fa-Liang An or Yan-Hua Lu.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Electronic supplementary material

Supporting Information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Further reading