Graphene and graphene derivatives (e.g., graphene oxide (GO)) have been incorporated into hydrogels to improve the properties (e.g., mechanical strength) of conventional hydrogels and/or develop new functions (e.g., electrical conductivity and drug loading/delivery). Unique molecular interactions between graphene derivatives and various small or macromolecules enable the fabrication of various functional hydrogels appropriate for different biomedical applications. In this mini-review, we highlight the recent progress in GO-incorporated hydrogels for biomedical applications while focusing on their specific uses as mechanically strong materials, electrically conductive scaffolds/electrodes, and high-performance drug delivery vehicles.
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Montheil T, Echalier C, Martinez J, Subra G, Mehdi A. Inorganic polymerization: an attractive route to biocompatible hybrid hydrogels. J Mater Chem B. 2018;6:3434–48.
Liu Y, He W, Zhang Z, Lee BP. Recent developments in tough hydrogels for biomedical applications. Gels. 2018;4:46.
Ahmed EM. Hydrogel: preparation, characterization, and applications: a review. J Adv Res. 2015;6:105–21.
Bahram M, Mohseni N, Moghtader M. An introduction to hydrogels and some recent applications. In: Emerging concepts in analysis and applications of hydrogels. 2016. https://doi.org/10.5772/64301.
Fu J, In Het Panhuis M. Hydrogel properties and applications. J Mater Chem B. 2019;7:1523–5.
Martín C, Martín-Pacheco A, Naranjo A, Criado A, Merino S, Díez-Barra E, et al. Graphene hybrid materials? The role of graphene materials in the final structure of hydrogels. Nanoscale. 2019;11:4822–30.
Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev. 2012;64:18–23.
Chai Q, Jiao Y, Yu X. Hydrogels for biomedical applications: their characteristics and the mechanisms behind them. Gels. 2017;3:6.
Xue K, Wang X, Yong PW, Young DJ, Wu Y-L, Li Z, et al. Hydrogels as emerging materials for translational. Biomed Adv Ther. 2019;2:1800088.
Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J. 2015;65:252–67.
Moghadam MN, Pioletti DP. Improving hydrogels' toughness by increasing the dissipative properties of their network. J Mech Behav Biomed Mater. 2015;41:161–7.
Akhtar MF, Hanif M, Ranjha NM. Methods of synthesis of hydrogels … a review. Saudi Pharm J. 2016;24:554–9.
Jiang Y-Y, Zhu Y-J, Li H, Zhang Y-G, Shen Y-Q, Sun T-W, et al. Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate. J Colloid Interface Sci. 2017;497:266–75.
Dai X, Zhang Y, Gao L, Bai T, Wang W, Cui Y, et al. A mechanically strong, highly stable, thermoplastic, and self-healable supramolecular polymer hydrogel. Adv Mater. 2015;27:3566–71.
Song F, Li X, Wang Q, Liao L, Zhang C. Nanocomposite hydrogels and their applications in drug delivery and tissue engineering. J Biomed Nanotechnol. 2015;11:40–52.
Liu X, Miller AL, Park S, Waletzki BE, Zhou Z, Terzic A, et al. Functionalized carbon nanotube and graphene oxide embedded electrically conductive hydrogel synergistically stimulates nerve cell differentiation. ACS Appl Mater Interfaces. 2017;9:14677–90.
Alam A, Meng Q, Shi G, Arabi S, Ma J, Zhao N, et al. Electrically conductive, mechanically robust, pH-sensitive graphene/polymer composite hydrogels. Compos Sci Technol. 2016;127:119–26.
Navaei A, Moore N, Sullivan T, Truong R, Q. Migrino D, Nikkhah R, et al. Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues. RSC Adv. 2017;7:3302–12.
Qazi TH, Rai R, Boccaccini AR. Tissue engineering of electrically responsive tissues using polyaniline based polymers: a review. Biomaterials. 2014;35:9068–86.
Hu X, Vatankhah-Varnoosfaderani M, Zhou J, Li Q, Sheiko SS. Weak hydrogen bonding enables hard, strong, tough, and elastic hydrogels. Adv Mater. 2015;27:6899–905.
Pumera M. Electrochemistry of graphene, graphene oxide and other graphenoids: review. Electrochem Commun. 2013;36:14–8.
Allen MJ, Tung VC, Kaner RB. Honeycomb carbon: a review of graphene. Chem Rev. 2010;110:132–45.
Huang Y, Zhang M, Ruan W. High-water-content graphene oxide/polyvinyl alcohol hydrogel with excellent mechanical properties. J Mater Chem A. 2014;2:10508–15.
Nath J, Chowdhury A, Dolui SK. Chitosan/graphene oxide-based multifunctional pH-responsive hydrogel with significant mechanical strength, self-healing property, and shape memory effect. Adv Polym Technol. 2018;37:3665–79.
Aliyev E, Filiz V, Khan MM, Lee YJ, Abetz C, Abetz V. Structural characterization of graphene oxide: surface functional groups and fractionated oxidative debris. Nanomaterials. 2019;9:1180.
Li C, Shi G. Functional gels based on chemically modified graphenes. Adv Mater. 2014;26:3992–4012.
Aderibigbe BA, Owonubi SJ, Jayaramudu J, Sadiku ER, Ray SS. Targeted drug delivery potential of hydrogel biocomposites containing partially and thermally reduced graphene oxide and natural polymers prepared via green process. Colloid Polym Sci. 2015;293:409–20.
Shin SR, Li Y-C, Jang HL, Khoshakhlagh P, Akbari M, Nasajpour A, et al. Graphene-based materials for tissue engineering. Adv Drug Deliv Rev. 2016;105:255–74.
Paik P. Graphene oxide for biomedical applications. J Nanomed Res. 2017;5:00136.
Bai H, Li C, Wang X, Shi G. On the gelation of graphene oxide. J Phys Chem C. 2011;115:5545–51.
Zhang Q, Wu Z, Li N, Pu Y, Wang B, Zhang T, et al. Advanced review of graphene-based nanomaterials in drug delivery systems: synthesis, modification, toxicity and application. Mater Sci Eng C. 2017;77:1363–75.
Zou X, Zhang L, Wang Z, Luo Y. Mechanisms of the antimicrobial activities of graphene materials. J Am Chem Soc. 2016;138:2064–77.
Lu X, Feng X, Werber JR, Chu C, Zucker I, Kim J-H, et al. Enhanced antibacterial activity through the controlled alignment of graphene oxide nanosheets. Proc Natl Acad Sci. 2017;114:E9793–801.
Gurunathan S, Kim J-H. Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials. Int J Nanomed. 2016;11:1927–45.
Jastrzębska AM, Kurtycz P, Olszyna AR. Recent advances in graphene family materials toxicity investigations. J Nanopart Res. 2012;14:1320.
Ou L, Song B, Liang H, Liu J, Feng X, Deng B, et al. Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms. Part Fibre Toxicol. 2016;13:57.
Dasari Shareena TP, McShan D, Dasmahapatra AK, Tchounwou PB. A review on graphene-based nanomaterials in biomedical applications and risks in environment and health. Nanomicro Lett. 2018;10:53.
Dervin S, Murphy J, Aviles R, Pillai SC, Garvey M. An in vitro cytotoxicity assessment of graphene nanosheets on alveolar cells. Appl Surf Sci. 2018;434:1274–84.
Kalbacova M, Broz A, Kong J, Kalbac M. Graphene substrates promote adherence of human osteoblasts and mesenchymal stromal cells. Carbon. 2010;48:4323–9.
Lee WC, Lim CHYX, Shi H, Tang LAL, Wang Y, Lim CT, et al. Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide. ACS Nano. 2011;5:7334–41.
Li J, Wang G, Geng H, Zhu H, Zhang M, Di Z, et al. CVD growth of graphene on NiTi alloy for enhanced biological activity. ACS Appl Mater Interfaces. 2015;7:19876–81.
Nayak TR, Andersen H, Makam VS, Khaw C, Bae S, Xu X, et al. Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano. 2011;5:4670–8.
de Luna LAV, de Moraes ACM, Consonni SR, Pereira CD, Cadore S, Giorgio S, et al. Comparative in vitro toxicity of a graphene oxide-silver nanocomposite and the pristine counterparts toward macrophages. J Nanobiotechnol. 2016;14:12.
Mendes RG, Koch B, Bachmatiuk A, Ma X, Sanchez S, Damm C, et al. A size dependent evaluation of the cytotoxicity and uptake of nanographene oxide. J Mater Chem B. 2015;3:2522–9.
Yue H, Wei W, Yue Z, Wang B, Luo N, Gao Y, et al. The role of the lateral dimension of graphene oxide in the regulation of cellular responses. Biomaterials. 2012;33:4013–21.
Bengtson S, Kling K, Madsen AM, Noergaard AW, Jacobsen NR, Clausen PA, et al. No cytotoxicity or genotoxicity of graphene and graphene oxide in murine lung epithelial FE1 cells in vitro. Environ Mol Mutagen. 2016;57:469–82.
Amrollahi-Sharifabadi M, Koohi MK, Zayerzadeh E, Hablolvarid MH, Hassan J, Seifalian AM. In vivo toxicological evaluation of graphene oxide nanoplatelets for clinical application. Int J Nanomed. 2018;13:4757–69.
Manjunatha B, Park SH, Kim K, Kundapur RR, Lee SJ. In vivo toxicity evaluation of pristine graphene in developing zebrafish (Danio rerio) embryos. Environ Sci Pollut Res. 2018;25:12821–9.
Wang K, Ruan J, Song H, Zhang J, Wo Y, Guo S, et al. Biocompatibility of graphene oxide. Nanoscale Res Lett. 2010;6:8.
Xu M, Zhu J, Wang F, Xiong Y, Wu Y, Wang Q, et al. Improved in vitro and in vivo biocompatibility of graphene oxide through surface modification: poly(acrylic acid)-functionalization is superior to PEGylation. ACS Nano. 2016;10:3267–81.
Park J, Choi JH, Kim S, Jang I, Jeong S, Lee JY. Micropatterned conductive hydrogels as multifunctional muscle-mimicking biomaterials: graphene-incorporated hydrogels directly patterned with femtosecond laser ablation. Acta Biomater. 2019;97:141–53.
Jo H, Sim M, Kim S, Yang S, Yoo Y, Park J-H, et al. Electrically conductive graphene/polyacrylamide hydrogels produced by mild chemical reduction for enhanced myoblast growth and differentiation. Acta Biomater. 2017;48:100–9.
Rosa V, Xie H, Dubey N, Madanagopal TT, Rajan SS, Morin JLP, et al. Graphene oxide-based substrate: physical and surface characterization, cytocompatibility and differentiation potential of dental pulp stem cells. Dent Mater. 2016;32:1019–25.
Garcia-Alegria E, Iliut M, Stefanska M, Silva C, Heeg S, Kimber SJ, et al. Graphene oxide promotes embryonic stem cell differentiation to haematopoietic lineage. Sci Rep. 2016;6:25917.
Kim T-H, Shah S, Yang L, Yin PT, Hossain MdK, Conley B, et al. Controlling differentiation of adipose-derived stem cells using combinatorial graphene hybrid-pattern arrays. ACS Nano. 2015;9:3780–90.
Luo Y, Shen H, Fang Y, Cao Y, Huang J, Zhang M, et al. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly(lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces. 2015;7:6331–9.
Park J, Park S, Ryu S, Bhang SH, Kim J, Yoon J-K, et al. Graphene‒regulated cardiomyogenic differentiation process of mesenchymal stem cells by enhancing the expression of extracellular matrix proteins and cell signaling molecules. Adv Healthc Mater. 2014;3:176–81.
Qiu Y, Wang Z, E. Owens AC, Kulaots I, Chen Y, B. Kane A, et al. Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology. Nanoscale. 2014;6:11744–55.
Choe G, Kim S-W, Park J, Park J, Kim S, Kim YS, et al. Anti-oxidant activity reinforced reduced graphene oxide/alginate microgels: mesenchymal stem cell encapsulation and regeneration of infarcted hearts. Biomaterials. 2019;225:119513.
Kim J, Kim Y-R, Kim Y, Taek Lim K, Seonwoo H, Park S, et al. Graphene-incorporated chitosan substrata for adhesion and differentiation of human mesenchymal stem cells. J Mater Chem B. 2013;1:933–8.
Wang F, Wen Y, Bai T. The composite hydrogels of polyvinyl alcohol–gellan gum-Ca2+ with improved network structure and mechanical property. Mater Sci Eng C. 2016;69:268–75.
Alam A, Zhang Y, Kuan H-C, Lee S-H, Ma J. Polymer composite hydrogels containing carbon nanomaterials—morphology and mechanical and functional performance. Prog Polym Sci. 2018;77:1–18.
Zhang S, Chen Y, Liu H, Wang Z, Ling H, Wang C, et al. Room-temperature-formed PEDOT:PSS hydrogels enable injectable, soft, and healable organic bioelectronics. Adv Mater. 2019:e1904752. https://doi.org/10.1002/adma.201904752.
Spencer AR, Primbetova A, Koppes AN, Koppes RA, Fenniri H, Annabi N. Electroconductive gelatin methacryloyl-PEDOT:PSS composite hydrogels: design, synthesis, and properties. ACS Biomater Sci Eng. 2018;4:1558–67.
Kleber C, Lienkamp K, Rühe J, Asplund M. Electrochemically controlled drug release from a conducting polymer hydrogel (PDMAAp/PEDOT) for local therapy and bioelectronics. Adv Healthc Mater. 2019;8:1801488.
Cha C, Shin SR, Gao X, Annabi N, Dokmeci MR, Tang XS, et al. Controlling mechanical properties of cell-laden hydrogels by covalent incorporation of graphene oxide. Small. 2014;10:514–23.
Li J, Illeperuma WRK, Suo Z, Vlassak JJ. Hybrid hydrogels with extremely high stiffness and toughness. ACS Macro Lett. 2014;3:520–3.
Yang C, Liu Z, Chen C, Shi K, Zhang L, Ju X-J, et al. Reduced graphene oxide-containing smart hydrogels with excellent electro-response and mechanical properties for soft actuators. ACS Appl Mater Interfaces. 2017;9:15758–67.
Ren J, Zhang A, Zhang L, Li Y, Yang W. Electrically conductive and mechanically tough graphene nanocomposite hydrogels with self-oscillating performance. Polym Int. 2019;68:1146–54.
Martín C, Merino S, González-Domínguez JM, Rauti R, Ballerini L, Prato M, et al. Graphene improves the biocompatibility of polyacrylamide hydrogels: 3D polymeric scaffolds for neuronal growth. Sci Rep. 2017;7:10942.
Yan X, Yang J, Chen F, Zhu L, Tang Z, Qin G, et al. Mechanical properties of gelatin/polyacrylamide/graphene oxide nanocomposite double-network hydrogels. Compos Sci Technol. 2018;163:81–88.
Valentin TM, Landauer AK, Morales LC, DuBois EM, Shukla S, Liu M, et al. Alginate-graphene oxide hydrogels with enhanced ionic tunability and chemomechanical stability for light-directed 3D printing. Carbon. 2019;143:447–56.
Das S, Irin F, Ma L, Bhattacharia SK, Hedden RC, Green MJ. Rheology and morphology of pristine graphene/polyacrylamide gels. ACS Appl Mater Interfaces. 2013;5:8633–40.
Zhang L, Wang Z, Xu C, Li Y, Gao J, Wang W, et al. High strength graphene oxide/polyvinyl alcohol composite hydrogels. J Mater Chem. 2011;21:10399–406.
Zhang N, Li R, Zhang L, Chen H, Wang W, Liu Y, et al. Actuator materials based on graphene oxide/polyacrylamide composite hydrogels prepared by in situ polymerization. Soft Matter. 2011;7:7231–9.
Kumar A, Zo SM, Kim JH, Kim S-C, Han SS. Enhanced physical, mechanical, and cytocompatibility behavior of polyelectrolyte complex hydrogels by reinforcing halloysite nanotubes and graphene oxide. Compos Sci Technol. 2019;175:35–45.
Luo H, Dong J, Yao F, Yang Z, Li W, Wang J, et al. Layer-by-layer assembled bacterial cellulose/graphene oxide hydrogels with extremely enhanced mechanical properties. Nanomicro Lett. 2018;10:42.
Shin JE, Kim HW, Yoo BM, Park HB. Graphene oxide nanosheet-embedded crosslinked poly(ethylene oxide) hydrogel. J Appl Polym Sci. 2018;135:45417.
Surudžić R, Janković A, Mitrić M, Matić I, Juranić ZD, Živković L, et al. The effect of graphene loading on mechanical, thermal and biological properties of poly(vinyl alcohol)/graphene nanocomposites. J Ind Eng Chem. 2016;34:250–7.
Goenka S, Sant V, Sant S. Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release. 2014;173:75–88.
Jang J, Hong J, Cha C. Effects of precursor composition and mode of crosslinking on mechanical properties of graphene oxide reinforced composite hydrogels. J Mech Behav Biomed Mater. 2017;69:282–93.
Shin SR, Aghaei‐Ghareh‐Bolagh B, Dang TT, Topkaya SN, Gao X, Yang SY, et al. Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide. Adv Mater. 2013;25:6385–91.
Zhou M, Lozano N, Wychowaniec JK, Hodgkinson T, Richardson SM, Kostarelos K, et al. Graphene oxide: a growth factor delivery carrier to enhance chondrogenic differentiation of human mesenchymal stem cells in 3D hydrogels. Acta Biomater. 2019;96:271–80.
Choe G, Oh S, Seok JM, Park SA, Lee JY. Graphene oxide/alginate composites as novel bioinks for three-dimensional mesenchymal stem cell printing and bone regeneration applications. Nanoscale. 2019;11:23275–85.
Wasalathilake KC, Galpaya DGD, Ayoko GA, Yan C. Understanding the structure-property relationships in hydrothermally reduced graphene oxide hydrogels. Carbon. 2018;137:282–90.
Bora C, Bharali P, Baglari S, Dolui SK, Konwar BK. Strong and conductive reduced graphene oxide/polyester resin composite films with improved mechanical strength, thermal stability and its antibacterial activity. Compos Sci Technol. 2013;87:1–7.
Compton OC, Nguyen ST. Graphene oxide, highly reduced graphene oxide, and graphene: versatile building blocks for carbon‐based materials. Small. 2010;6:711–23.
Sayyar S, Murray E, C. Thompson B, Chung J, L. Officer D, Gambhir S, et al. Processable conducting graphene/chitosan hydrogels for tissue engineering. J Mater Chem B. 2015;3:481–90.
Jing X, Mi H-Y, Peng X-F, Turng L-S. Biocompatible, self-healing, highly stretchable polyacrylic acid/reduced graphene oxide nanocomposite hydrogel sensors via mussel-inspired chemistry. Carbon. 2018;136:63–72.
Li L, Wang Y, Pan L, Shi Y, Cheng W, Shi Y, et al. A nanostructured conductive hydrogels-based biosensor platform for human metabolite detection. Nano Lett. 2015;15:1146–51.
Green R. Elastic and conductive hydrogel electrodes. Nat Biomed Eng. 2019;3:9–10.
Liu X, Kim JC, Miller AL, Waletzki BE, Lu L. Electrically conductive nanocomposite hydrogels embedded with functionalized carbon nanotubes for spinal cord injury. N J Chem. 2018;42:17671–81.
Zhou J, Yang X, Liu W, Wang C, Shen Y, Zhang F, et al. Injectable OPF/graphene oxide hydrogels provide mechanical support and enhance cell electrical signaling after implantation into myocardial infarct. Theranostics. 2018;8:3317–30.
Yang S, Jang L, Kim S, Yang J, Yang K, Cho S, et al. Polypyrrole/alginate hybrid hydrogels: electrically conductive and soft biomaterials for human mesenchymal stem cell culture and potential neural tissue engineering applications. Macromol Biosci. 2016;16:1653–61.
Li D-F, Wang W, Wang H-J, Jia X-S, Wang J-Y. Polyaniline films with nanostructure used as neural probe coating surfaces. Appl Surf Sci. 2008;255:581–4.
Dai T, Qing X, Lu Y, Xia Y. Conducting hydrogels with enhanced mechanical strength. Polymer. 2009;50:5236–41.
Shi Y, Ma C, Peng L, Yu G. Conductive “smart” hybrid hydrogels with PNIPAM and nanostructured conductive polymers. Adv Funct Mater. 2015;25:1219–25.
Wan C, Chen B. Reinforcement and interphase of polymer/graphene oxide nanocomposites. J Mater Chem. 2012;22:3637–46.
Liu R, Liang S, Tang X-Z, Yan D, Li X, Yu Z-Z. Tough and highly stretchable graphene oxide/polyacrylamide nanocomposite hydrogels. J Mater Chem. 2012;22:14160–7.
Qian Y, Song J, Zhao X, Chen W, Ouyang Y, Yuan W, et al. 3D fabrication with integration molding of a graphene oxide/polycaprolactone nanoscaffold for neurite regeneration and angiogenesis. Adv Sci. 2018;5:1700499.
Dreyer DR, Park S, Bielawski CW, Ruoff RS. The chemistry of graphene oxide. Chem Soc Rev. 2009;39:228–40.
Jing X, Mi H-Y, Napiwocki BN, Peng X-F, Turng L-S. Mussel-inspired electroactive chitosan/graphene oxide composite hydrogel with rapid self-healing and recovery behavior for tissue engineering. Carbon. 2017;125:557–70.
Shin SR, Zihlmann C, Akbari M, Assawes P, Cheung L, Zhang K, et al. Reduced graphene oxide-GelMA hybrid hydrogels as scaffolds for cardiac tissue engineering. Small. 2016;12:3677–89.
Li J, Mooney DJ. Designing hydrogels for controlled drug delivery. Nat Rev Mater. 2016;1:16071.
Narayanaswamy R, Torchilin VP. Hydrogels and their applications in targeted drug delivery. Molecules. 2019;24:603.
Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev. 2012;64:49–60.
Ashley GW, Henise J, Reid R, Santi DV. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc Natl Acad Sci. 2013;110:2318–23.
Hoare TR, Kohane DS. Hydrogels in drug delivery: progress and challenges. Polymer. 2008;49:1993–2007.
Merino S, Martín C, Kostarelos K, Prato M, Vázquez E. Nanocomposite hydrogels: 3D polymer–nanoparticle synergies for on-demand drug delivery. ACS Nano. 2015;9:4686–97.
Dannert C, Stokke BT, Dias RS. Nanoparticle-hydrogel composites: from molecular interactions to macroscopic behavior. Polymers. 2019;11:275.
Thoniyot P, Tan MJ, Karim AA, Young DJ, Loh XJ. Nanoparticle–hydrogel composites: concept, design, and applications of these promising, multi-functional materials. Adv Sci. 2015;2:1400010.
Wang J, Liu C, Shuai Y, Cui X, Nie L. Controlled release of anticancer drug using graphene oxide as a drug-binding effector in konjac glucomannan/sodium alginate hydrogels. Colloids Surf B Biointerfaces. 2014;113:223–9.
Chen K, Ling Y, Cao C, Li X, Chen X, Wang X. Chitosan derivatives/reduced graphene oxide/alginate beads for small-molecule drug delivery. Mater Sci Eng C. 2016;69:1222–8.
Kim S, Yoo Y, Kim H, Lee E, Lee JY. Reduction of graphene oxide/alginate composite hydrogels for enhanced adsorption of hydrophobic compounds. Nanotechnology. 2015;26:405602.
Chen Y, Cheng W, Teng L, Jin M, Lu B, Ren L, et al. Graphene oxide hybrid supramolecular hydrogels with self-healable, bioadhesive and stimuli-responsive properties and drug delivery application. Macromol Mater Eng. 2018;303:1700660.
Bai H, Li C, Wang X, Shi G. A pH-sensitive graphene oxide composite hydrogel. Chem Commun. 2010;46:2376.
Wu J, Chen A, Qin M, Huang R, Zhang G, Xue B, et al. Hierarchical construction of a mechanically stable peptide–graphene oxide hybrid hydrogel for drug delivery and pulsatile triggered release in vivo. Nanoscale. 2015;7:1655–60.
Liu W, Zhang X, Zhou L, Shang L, Su Z. Reduced graphene oxide (rGO) hybridized hydrogel as a near-infrared (NIR)/pH dual-responsive platform for combined chemo-photothermal therapy. J Colloid Interface Sci. 2019;536:160–70.
Liu H-W, Hu S-H, Chen Y-W, Chen S-Y. Characterization and drug release behavior of highly responsive chip-like electrically modulated reduced graphene oxide–poly(vinyl alcohol) membranes. J Mater Chem. 2012;22:17311.
Mac Kenna N, Calvert P, Morrin A, Wallace GG, Moulton SE. Electro-stimulated release from a reduced graphene oxide composite hydrogel. J Mater Chem B. 2015;3:2530–7.
Chen B, Liu M, Zhang L, Huang J, Yao J, Zhang Z. Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. J Mater Chem. 2011;21:7736.
Zhang L, Lu Z, Zhao Q, Huang J, Shen H, Zhang Z. Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. Small. 2011;7:460–4.
Paul A, Hasan A, Kindi HA, Gaharwar AK, Rao VT, Nikkhah M, et al. Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS Nano. 2014;8:8050–62.
Chengnan L, Pagneux Q, Voronova A, Barras A, Abderrahmani A, Plaisance V, et al. Near-infrared light activatable hydrogels for metformin delivery. Nanoscale. 2019;11:15810–20.
Rasoulzadeh M, Namazi H. Carboxymethyl cellulose/graphene oxide bio-nanocomposite hydrogel beads as anticancer drug carrier agent. Carbohydr Polym. 2017;168:320–6.
This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2019R1A2C2002515 and NRF-2019M3C1B8090799).
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Yi, J., Choe, G., Park, J. et al. Graphene oxide-incorporated hydrogels for biomedical applications. Polym J 52, 823–837 (2020). https://doi.org/10.1038/s41428-020-0350-9
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