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ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia

Cellular & Molecular Immunology volume 21, pages 203–204 (2024)Cite this article

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B cells have an essential immunoregulatory function, which is mediated by the secretion of IL-10 and TGFβ and interaction with activated CD4+ T cells. This antibody-independent function of B cells contributes to ameliorating autoimmune diseases or infection-induced tissue damage. In this Cellular and Molecular Immunology issue, Fu et al. demonstrated that regulatory B (Breg) cells play a critical role in resolving Pseudomonas aeruginosa-induced pneumonia [1]. The authors identify B cells as critical regulators that maintain tissue homeostasis by investigating immune cells in bronchoalveolar lavage fluid during the progression and resolution of pneumonia. The levels of B cells, which increased significantly four days after infection, were inversely correlated with disease severity, and the expression of IL-10 was required for immune regulation.

This work is interesting in that it shows the role of B cells in the resolution of inflammation at the early phase of infection. As is well established, macrophages are critical in recovery from infection, as they remove debris from dead cells and supply growth-promoting factors for tissue regeneration [3]. Progression from the acute to recovery phases of infection converts macrophages from inflammatory macrophages to tissue repair macrophages. Furthermore, regulatory T cells and myeloid-derived suppressor cells are also implicated in the cessation of persistent inflammation. B cells have been newly defined as tissue homeostatic regulators, especially in the early resolution period of approximately four days to a week.

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References

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  1. Department of Immunology, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea

    Sujin Lee & Tae Jin Kim

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  1. Sujin Lee
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  2. Tae Jin Kim
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Correspondence to Tae Jin Kim.

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Lee, S., Kim, T.J. ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia. Cell Mol Immunol 21, 203–204 (2024). https://doi.org/10.1038/s41423-023-01117-7

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  • DOI: https://doi.org/10.1038/s41423-023-01117-7

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