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FSP1 oxidizes NADPH to suppress ferroptosis

Cell Research volume 33, pages 967–970 (2023)Cite this article

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Dear Editor,

Ferroptosis is a form of non-apoptotic cell death characterized by the accumulation of iron-dependent lipid peroxides and oxidative damage to cell membrane.1 Discovered relative recently, ferroptosis is morphologically and mechanistically distinct from other forms of cell death, such as apoptosis, necroptosis, and pyroptosis.2 Ferroptosis has been implicated in various pathological conditions, including neurodegenerative diseases, cancer, and ischemia-reperfusion injury.3,4,5 Thus, studying ferroptosis could not only provide insights into the fundamental mechanisms of cell death and survival, but also identify new targets for therapeutic intervention in a variety of pathological conditions.

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Fig. 1: FSP1 utilizes NADPH, but not NADH, to suppress ferroptosis.

Data availability

Structure factor and atomic coordinates were deposited to the Protein Data Bank with accession code 8JSC.

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Acknowledgements

We thank members of our laboratory for helpful discussions. This work was supported by the National Key R&D Program of China (2022YFA1105200), the National Natural Science Foundation of China (92254302), and the National Science Fund for Distinguished Young Scholars (32125012).

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Author notes

  1. These authors contributed equally: Sitao Zhang, Shengsong Gou, Qian Zhang.

Authors and Affiliations

  1. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, China

    Sitao Zhang, Shengsong Gou, Qian Zhang, Xin Yong & Da Jia

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Boyi Gan

Authors
  1. Sitao Zhang
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  2. Shengsong Gou
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  3. Qian Zhang
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  4. Xin Yong
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  5. Boyi Gan
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  6. Da Jia
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Contributions

S.Z. performed biochemical and structural studies together with Q.Z. S.G. performed cellular studies, and X.Y. provided technical assistance. B.G. provided intellectual assistance and edited the manuscript. D.J. supervised the project and prepared the manuscript with input from every author.

Corresponding author

Correspondence to Da Jia.

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The authors declare no competing interests.

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Zhang, S., Gou, S., Zhang, Q. et al. FSP1 oxidizes NADPH to suppress ferroptosis. Cell Res 33, 967–970 (2023). https://doi.org/10.1038/s41422-023-00879-z

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