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Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity

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Fig. 1: Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity.

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Acknowledgements

We thank Drs. Junying Yuan and Nan Liu for critical reading of the manuscript. We thank J. Hu Lab and Y. Geng for help with live-cell imaging. We thank Z. Zhang Lab for the protein purification platform. We thank National Center for Protein Science Shanghai for the BLI assays. This work was supported by the National Key R&D Program of China (2016YFA0501900), the National Natural Science Foundation of China (21532002 and 21877123), the Shanghai Municipal Science and Technology Major Project (2019SHZDZX02), and the joint postdoc program with Janssen R&D.

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G.Z., J.X., X.G., and J.Z. designed the study. G.Z., J.X., Z.F., and Z.C. performed the experiments. M.W. synthesized the compounds. G.Z., J.X., Q.Z., H.H., and J.Z. analyzed the data. G.Z., J.X., and J.Z. wrote the manuscript.

Corresponding author

Correspondence to Jidong Zhu.

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Competing interests

J.Z. is a co-founder of Etern Biopharma Co., Ltd. and a member of its scientific advisory board. H.H., Z.C., and X.G. are employees of Etern Biopharma Co., Ltd.

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Zhu, G., Xie, J., Fu, Z. et al. Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity. Cell Res (2021). https://doi.org/10.1038/s41422-021-00504-x

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