Abstract
Although the literature about the functions of hyaluronan and the CD44 receptor in the brain and brain tumours is extensive, the role of the receptor for hyaluronan-mediated motility (RHAMM) in neural stem cells and gliomas remain poorly explored. RHAMM is considered a multifunctional receptor which performs various biological functions in several normal tissues and plays a significant role in cancer development and progression. RHAMM was first identified for its ability to bind to hyaluronate, the extracellular matrix component associated with cell motility control. Nevertheless, additional functions of this protein imply the interaction with different partners or cell structures to regulate other biological processes, such as mitotic-spindle assembly, gene expression regulation, cell-cycle control and proliferation. In this review, we summarise the role of RHAMM in normal brain development and the adult brain, focusing on the neural stem and progenitor cells, and discuss the current knowledge on RHAMM involvement in glioblastoma progression, the most aggressive glioma of the central nervous system. Understanding the implications of RHAMM in the brain could be useful to design new therapeutic approaches to improve the prognosis and quality of life of glioblastoma patients.
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Data availability
The datasets used and/or analysed during this study are available from the corresponding author upon reasonable request.
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Acknowledgements
We are grateful to CONICET, FONCYT and UBA for providing the funding that supported this review.
Funding
This work was supported by Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET-PIP N°053 [Élida Álvarez and Silvia Hajos] and PIP N°0298 [Paula Franco], Universidad de Buenos Aires-UBACYT 20020170100454BA [Silvia Hajos and Silvina Lompardia] and UBACYT 200201190100048BA [Paula Franco], Agencia Nacional de Promoción Científica y Tecnológica PICT-2017-2971 [Lompardía Silvina].
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MAP searched the bibliography, created the figures, analysed the data and wrote the manuscript. DP and YAM performed the edition of figures and analysed the bibliography. MD, AB and SA contributed to the design of the study and edition of the manuscript. SH and SL collaborated in the edition of the manuscript and contributed to the design of the study. PF supervised the work. All authors contributed to the work and have read and approved the final manuscript.
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Pibuel, M.A., Poodts, D., Molinari, Y. et al. The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles. Br J Cancer 128, 12–20 (2023). https://doi.org/10.1038/s41416-022-01999-w
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DOI: https://doi.org/10.1038/s41416-022-01999-w