Sir, I read the article by Kandhari et al.1 with interest: bone quality, volume, height and width all play a pivotal role in dental implant stability, success and survival. Most young dentists are unable to determine whether the implant area has sufficient bone mass during the implantation process. Meanwhile, selecting the right type of bone grafting material is also extremely challenging. A lack of adequate bone can be overcome with various bone grafting procedures. Long-term and stable implants depend on many factors including the amount of bone required, the site of implant placement, patient preferences and clinician factors. The authors provided an overview of bone grafting indications, materials and types of bone grafting techniques, while discussing the properties needed to ensure optimal success of guided bone regeneration techniques.

Recently, one clinical study evaluated the combined use of concentrated growth factors (CGFs) and adipose-derived stem cells (ADSCs) as cytokines and seed cells for bone regeneration in patients with immediate dental implants. Shubham et al.2 showed that although there was no significant difference in results between groups at all time points, the application of concentrated platelets unexpectedly improved the stability of implants after surgery. When comparing the quantity and quality of bone regeneration for data statistics and measurements, the difference between the three groups was not statistically significant. Another clinical study by Andrea et al.3 found that data obtained from surgical interventions with CGF-permeated dental implants presented better results in terms of optimal osseointegration and reduced post-surgical complications. These data, taken together, highlight new and interesting perspectives in the use of CGF in the dental implantology field to improve osseointegration and promote the healing process.

CGF, as a healing biomaterial, has been routinely applied in dental implant surgery to accelerate healing and reduce post-operative discomfort, which has a positive impact on the success of dental implantation. In order to increase the long-term stability of implants, we need to explore more effective methods, and the use of growth factors is one of them.