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Impact of pre-transplantation depression and anxiety on the outcome of allogeneic hematopoietic stem cell transplantation: a study from the Transplant Complications Working Party of the EBMT

Bone Marrow Transplantation volume 58, pages 1279–1281 (2023)Cite this article

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TO THE EDITOR:

Around 3–15% of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) suffer from pre-transplantation depression or anxiety [1,2,3,4,5]. Several small prospective studies looking at the influence of pre-transplantation psychological variables—including depression and anxiety—on survival after allogeneic HSCT have yielded conflicting results [6,7,8,9,10,11]. More recently, two larger cohort studies from the Center for International Blood and Marrow Transplant Research (CIBMTR) and South Korea, respectively, found that pre-transplantation depression was associated with inferior overall survival (OS) after allogeneic HSCT [1, 2]. However, since the prevalence of depression and anxiety differs across the globe [12], the generalizability of these results need to be verified in different geographical settings. We therefore aimed to investigate the impact of pre-transplantation depression or anxiety on outcomes after allogeneic HSCT using data from the European Society for Blood and Marrow Transplantation (EBMT) registry.

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Fig. 1

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Acknowledgements

The authors would like to thank the EBMT Transplant Complications Working Party for their support of the study.

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Authors and Affiliations

  1. Department of Hematology, Rigshospitalet, Copenhagen, Denmark

    Lars Klingen Gjærde

  2. EBMT Paris Study Office, St Antoine Hospital, Sorbonne University, Paris, France

    Christophe Peczynski & Emmanuelle Polge

  3. University Hospital Eppendorf, Hamburg, Germany

    Nicolaus Kröger

  4. Saint-Louis Hospital, Paris, France

    Régis Peffault de Latour

  5. University of Freiburg, Freiburg, Germany

    Jürgen Finke

  6. University of Regensburg, Regensburg, Germany

    Ernst Holler

  7. Transplant and Cellular Immunotherapy Program, Department of Hematology, Aix Marseille University, Management Sport Cancer (MSC), Institut Paoli Calmettes, Marseille, France

    Didier Blaise

  8. Silesian Medical Academy, Katowice, Poland

    Grzegorz Helbig

  9. HUCH Comprehensive Cancer Center, Helsinki, Finland

    Urpu Salmenniemi

  10. GKT School of Medicine, King`s Denmark Hill Campus, London, UK

    Victoria Potter

  11. University Clinic Ulm, Ulm, Germany

    Donald Bunjes

  12. Clinical Hematology and BMT Unit, Targu Mures, Romania

    Lazar Erzsebet

  13. Charité Universitätsmedizin Berlin, Berlin, Germany

    Olaf Penack

  14. Department of Hematology, University Hospitals Leuven, Leuven, Belgium

    Hélène Schoemans

  15. Department of Public Health and Primary Care, ACCENT VV, KU Leuven - University of Leuven, Leuven, Belgium

    Hélène Schoemans

  16. Hannover Medical School, Hannover, Germany

    Christian Koenecke

  17. Medical University of Warsaw, Warsaw, Poland

    Grzegorz W. Basak

  18. School of Medicine, University Clinical Hospital Zagreb, Zagreb, Croatia

    Zinaida Perić

Authors
  1. Lars Klingen Gjærde
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  2. Christophe Peczynski
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  4. Nicolaus Kröger
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  12. Donald Bunjes
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  16. Christian Koenecke
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  17. Grzegorz W. Basak
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  18. Zinaida Perić
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Contributions

LKG interpreted the results and wrote the first version of the paper. CK, HS, OP, GB, and ZP designed the study, supervised the research, interpreted the results, and revised the paper. EP and CP assembled the dataset, performed the statistical analyses, and revised the paper. All other co-authors collected data, recruited patients, and revised the paper.

Corresponding author

Correspondence to Zinaida Perić.

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The authors declare no competing interests.

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Gjærde, L.K., Peczynski, C., Polge, E. et al. Impact of pre-transplantation depression and anxiety on the outcome of allogeneic hematopoietic stem cell transplantation: a study from the Transplant Complications Working Party of the EBMT. Bone Marrow Transplant 58, 1279–1281 (2023). https://doi.org/10.1038/s41409-023-02067-4

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