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Pneumocystis jirovecii Infection in autologous hematopoietic stem cell transplant recipients

Bone Marrow Transplantation volume 58, pages 446–451 (2023)Cite this article

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Pneumocystis jirovecii pneumonia (PJP) is a respiratory infection caused by an opportunistic fungus occurring among immunocompromised individuals, which can cause severe respiratory illness with high mortality. Individuals receiving hematopoietic stem cell transplantation (HSCT) are susceptible to PJP.

Among HSCT patients, the association with PJP is best demonstrated in those receiving allogeneic transplants. Prior to the routine use of prophylaxis, rates of PJP were reported between 6 and 16% after allogeneic HSCT [1,2,3]. Incidence has declined since the incorporation of routine prophylaxis, with rates reported between 0.63 and 3.52% [4,5,6,7,8,9].

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Fig. 1: Absolute lymphocyte count (ALC) recovery after autologous hematopoietic stem cell transplant.

Data availability

The datasets generated during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was supported by National Institutes of Health grants (National Institute of Aging: P30-AG024824, MJP), (National Cancer Institute: P30-CA046592, University of Michigan Cancer Center Support Grant, PI: Eric Fearon MD, Ph.D.), and (National Center for Advancing Translational Sciences: UL1-TR00457, MJP).

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Authors and Affiliations

  1. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    John Coda

  2. Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI, USA

    Kadee Raser, Sarah M. Anand, Monalisa Ghosh, John J. Maciejewski, Attaphol Pawarode, Mary M. Riwes, Christina Tillman, Sung Won Choi, Gregory A. Yanik & John M. Magenau

  3. Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Sarah M. Anand, Monalisa Ghosh, John J. Maciejewski, Attaphol Pawarode, Mary M. Riwes, Avery Polk, Malathi Kandarpa, Moshe Talpaz, Gregory A. Yanik, John M. Magenau & Matthew J. Pianko

  4. Division of Infectious Disease, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Kevin Gregg

  5. Department of Biostatistics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA

    Jinju Li

  6. Division of Hematology/Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA

    Sung Won Choi

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  1. John Coda
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Contributions

Study conception and design: JC, KR, GY, JMM, and MJP. Data collection: JC, KR, SA, MG, JJM, AP, MR, CT, GY, JMM, SWC, AP, MK, MT. Data analysis: JC, JL, and MJP. Manuscript writing: JC, KG, JMM, SWC, and MJP. Review and final approval of manuscript: all authors

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Correspondence to Matthew J. Pianko.

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Coda, J., Raser, K., Anand, S.M. et al. Pneumocystis jirovecii Infection in autologous hematopoietic stem cell transplant recipients. Bone Marrow Transplant 58, 446–451 (2023). https://doi.org/10.1038/s41409-022-01906-0

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